HKI-272片剂 ｜已完成

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基本信息

数据来源:临床试验登记与信息公示平台，查看原文请点击
登记号
CTR20181596
相关登记号
CTR20181278;
曾用名
药物类型
化学药物
临床申请受理号
企业选择不公示
适应症
乳腺癌
试验通俗题目
HKI-272 应用于曲妥珠单抗治疗后的早期乳腺癌女性的临床研究
试验专业题目
Neratinib (HKI-272) 应用于曲妥珠单抗治疗后的HER-2/neu过表达/扩增的早期乳腺癌女性患者的随机、双盲、安慰剂对照临床研究
试验方案编号
3144A2-3004-WW；修订版13
方案最近版本号
版本日期
方案是否为联合用药
企业选择不公示

申请人信息

申请人名称
联系人姓名
周小芬
联系人座机
021-5111 8000
联系人手机号
联系人Email
cindy.zhou@parexel.com
联系人邮政地址
北京市朝阳区朝阳门外大街乙12号昆泰国际大厦15层1505室
联系人邮编
10020

临床试验信息

试验分类
安全性和有效性
试验分期
III期
试验目的
这是一项随机、双盲、安慰剂对照3 期研究，在接受过曲妥珠单抗治疗的早期 erbB-2 过表达/扩增乳腺癌女性中比较 neratinib 和安慰剂的疗效
随机化
随机化
盲法
双盲
试验范围
国际多中心试验
设计类型
平行分组
年龄
18岁(最小年龄)至 无岁(最大年龄)
性别
女
健康受试者
无
入选标准
  • 经下述某一方法进行局部测定证实,受试者的乳腺癌组织学类型必须为是原发性腺癌且呈 erbB-2 阳性:荧光原位杂交或银染原位杂交 (SISH) 必须显示基因扩增(标准为 >2.2 倍扩增),或者显色原位杂交 (CISH) 显示出有基因扩增(按照制造商的试剂盒说明),或者免疫组化测定必须显示强阳性(也即,>30% 的侵袭性肿瘤细胞呈 3+)染色结果
  • 必须有既往留存的诊断性肿瘤样本,且受试者必须同意为研究中心 erbB-2 测定提交样本. (关于确认入组资格,也可以应用当地实验室的 erbB-2 检测结果。)
  • 在研究入组之前必须已知原发肿瘤的 ER/PgR 状态
  • 受试者之前必须已完成一个疗程的曲妥珠单抗辅助化疗。如果所接受的曲妥珠单抗治疗时间不足 12 个月,则必须已接受至少 8 剂每周一次的曲妥珠单抗治疗,或至少 3 剂每 3 周一次的曲妥珠单抗治疗。另外,必须要注明受试者自 1)完成既定疗程的基于已发表数据(FinHER 方案)的曲妥珠单抗辅助化疗后,或 2)出现导致曲妥珠单抗提前停药但后来又消退的副作用后,不适合或不能继续接受曲妥珠单抗辅助化疗
  • 如果受试者既往接受了新辅助化疗(含或不含曲妥珠单抗新辅助化疗的化疗;不管初始确诊时的淋巴结状态如何),那么只用当她们在完成新辅助化疗后仍在乳腺和 /或腋窝内残存侵袭性癌灶时才符合入选资格。如果受试者的乳腺和腋窝(如果腋窝状态已知)病灶达到了病理学完全缓解 (pCR),或者她们仅在乳腺内残存原位病灶 (DCIS) 但在腋窝内达到 pCR(如果腋窝状态已知),那么受试者将被排除在外
  • 曲妥珠单抗的末次给药时间距离随机分配必须已有 >2 周但 ≤1 年(365 天)
  • 根据美国癌症联合委员会(第六版)的乳腺癌分期标准,被确诊为患有 2 到 3c 期原发性乳腺癌伴随腋窝淋巴结阳性病灶。(现特此澄清,孤立肿瘤细胞视为 pN0, 微转移灶视为 pN1。) 请注意,已完成新辅助化疗且仅在乳腺内残存侵袭性病灶但淋巴结状态为阴性或未知的受试者具备入选资格
  • 经充分手术的原发性乳腺癌,也即乳腺切除术或乳房肿瘤切除术后的乳腺癌、切缘无侵袭性癌灶和原位导管癌。前哨淋巴结活检呈阳性的受试者,只有接受序贯淋巴结切除术后,才具备入选资格
  • 已完成一种含蒽环类药物和/或紫杉烷或任何一种环磷酰胺+甲氨蝶呤+5-氟尿嘧啶 (CMF) 方案的新辅助化疗和/或辅助化疗
  • 进入研究时经临床和影像学评估排除局灶性或局部复发灶或转移灶,包括骨扫描;仅当碱性磷酸酶 (ALP)22 倍正常值上限 (ULN) 和/或存在骨转移灶症状时才需要。如果骨扫描的结果不可靠,则需进行确诊性成像检查。腹部和胸部的计算机断层成像 (CT)、MRI 或超声扫描;仅当天冬氨酸转氨酶 (AST)/丙氨酸转氨酶 (ALT) 或 ALP 22 x ULN 时才需要;胸部 X 光照片
  • 随机分配前 12 个月(< 365 天)内的双侧乳腺乳房X光检查(或者,若进行了单侧全乳房切除术,则对残存侧乳腺进行单侧乳房X光检查)结果为阴性。如果进行了双侧乳房全切术,则无需进行乳房X光检查
  • 双侧乳腺癌受试者只有在双侧癌灶为同步出现时才具备入选资格(也即,同时确诊 [彼此相隔不超过 6 个月])。有一侧或两侧肿瘤须为 erbB-2 阳性。可有一侧为阴性
  • 年龄为 18 岁或以上的女性受试者。(对于日本:20 岁或以上)
  • 受试者的东部肿瘤协作组 (ECOG) 体能状况评分必须为 0 到 1 分
  • QTc 间期必须 <0.450 秒
  • 器官功能足够好的定义为:中性粒细胞绝对计数:21.5 × 109/L (1500/mm3)。血小板计数:2100 × 109/L (100,000/mm3)。血红蛋白:29.0 g/dL (90 g/L)。血清肌酸酐:<1.5 x ULN。总胆红素:<1.5 × ULN(若存在已知的 Gilbert 综合征,则允许 <2 x ULN)。AST 和 ALT:<2.5 × ULN。ALP:<2.5 x ULN
  • 左心室射血分数 (LVEF) 位于研究中心所设定的正常范围之内,采用多门控采集 (MUGA) 或超声心动图 (ECHO) 测定
  • 对于具有生殖能力(能够亲身生育后代)的绝经前女性以及绝经不足 12 个月的女性,β-HCG 妊娠试验(血清)须为阴性。所有能够亲身生育后代的女性受试者必须同意并承诺,自接受首剂试验性药物前 2 周起直至接受最后一剂试验性药物后 28 天,坚持使用一种可靠的避孕措施
  • 所有与既往治疗有关的具有临床意义的 AE(除外脱发、神经病变和指甲变化)均已恢复(也即,恢复至 1 级或基线水平)
排除标准
  • 在进入研究前或进入研究时经临床或放射学检查证实存在局灶性或局部复发灶或转移灶
  • 当前正在接受乳腺癌的化疗、放疗、免疫治疗或生物疗法
  • 既往接受任何纵膈放疗，除外为当前乳腺癌进行的内乳淋巴结照射
  • 异时性侵袭性乳腺癌或异时性DCIS 乳腺癌（也即，在不同时间确诊原发性乳腺癌[确诊间隔超过6 个月]）
  • 既往曾使用除曲妥珠单抗以外的erbB-1 和/或erbB-2 抑制剂
  • 在接受第一剂试验性药品前14 天内或5 个半衰期内（取较长者）使用过任何试验性制剂
  • 已怀孕或正在哺乳的女性
  • 受试者存在除充分经治非黑色素瘤皮肤癌、原位黑色素瘤或原位宫颈癌以外的第二种恶性肿瘤。存在其他非乳腺恶性肿瘤的受试者必须已维持无病至少5 年
  • 受试者患有不稳定心绞痛、充血性心衰（纽约心脏协会II、III 或IV 级心功能）（包括目前正在使用洋地黄、β受体阻滞剂或钙通道阻滞剂治疗充血性心衰）、需要药物治疗的室性心律失常或者在12 个月内有心肌梗死史
  • 存在活动性未愈合感染的受试者
  • 不能够或者不愿意吞服药片
  • 以腹泻为主要症状的重要慢性胃肠道疾病（如克罗恩病、溃疡性结肠炎、吸收不良或在基线期存在任何病因导致的≥2 级腹泻）
  • QTc 间期> 0.450 秒或者已知存在QTc 延长病史或尖端扭转型室性心动过速病史
  • 有突发性室性心动过速或室颤病史
  • 受试者存在精神疾病，使其不能正常理解试验性治疗的性质以及遵守方案要求
  • 存在任何重大共患病或异常状态，经研究者判断，可明显增加受试者在参加和完成本研究时所伴随的风险
  • 正在参加任何其他以DFS 作为终点的乳腺癌新辅助化疗或辅助化疗试验，目前正处于治疗期或随访期

试验分组

试验药
名称 用法
中文通用名:HKI-272片剂
用法用量:40 mg 片剂，每日随食物口服一次，每次6 粒，最好是在早上，持续服用1 年。
对照药
名称 用法
中文通用名:安慰剂
用法用量:40 mg 片剂，每日随食物口服一次，每次6 粒，最好是在早上，持续服用1 年。

终点指标

主要终点指标
指标 评价时间 终点指标选择
无病生存期(DFS) 整个研究期间 有效性指标+安全性指标
次要终点指标
指标 评价时间 终点指标选择
DCIS ：从随机分配至首次出现DFS 事件复发或DCIS 的时间 整个研究期间 有效性指标+安全性指标
远处转移时间(TTDR) 整个研究期间 有效性指标+安全性指标
远期无病生存期(DDFS) 整个研究期间 有效性指标+安全性指标
CNS 复发率 整个研究期间 有效性指标+安全性指标
总生存期 整个研究期间 有效性指标+安全性指标
数据安全监察委员会（DMC）
无
为受试者购买试验伤害保险
有

研究者信息

姓名 学位 职称 电话 Email 邮政地址 邮编 单位名称
徐兵河，医学博士 主任医师 +861087788826 bhxu@hotmail.com 北京市朝阳区潘家园南里17号 100021 中国医学科学院肿瘤医院

各参加机构信息

机构名称 （主要）研究者 国家 地区 城市
中国医学科学院肿瘤医院 徐兵河 中国 北京 北京
中山大学附属肿瘤医院 王树森 中国 广东 广州
复旦大学附属肿瘤医院 沈镇宙 中国 上海 上海
浙江省肿瘤医院 王晓稼 中国 浙江 杭州
天津市肿瘤医院 佟仲生 中国 天津 天津
北京协和医学院肿瘤医院 孙强 中国 北京 北京
中国人民解放军总医院(301医院)_ 杨俊兰 中国 北京 北京
解放军第307医院 江泽飞 中国 北京 北京
Breast Cancer Research Centre – WA Chan Arlene Australia Western Australia Nedlands
Calvary Hospital North Adelaide Patterson William Australia South Australia North Adelaide
Ashford Cancer Centre Research Kotasek Dusan Australia South Australia Kurralta Park
Mater Private Centre Coward Jermaine Australia Queensland South Brisbane
Royal Melbourne Hospital De Boer Richard Australia Victoria Parkville
Campbell David Sunshine Hospital Australia Victoria St Albans
The Queen Elizabeth Hospital Patterson William Australia South Australia Woodville
University of Sydney Hui Rina Australia New South Wales Westmead
Jerusalem Guy CHU de Liège - Domaine Universitaire du Sart Tilman Belgium Liège Liège
Onze Lieve Vrouwziekenhuis - Campus Aalst Huygh Greet Belgium Oost-Vlaanderen Aalst
Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie Mebis Jeroen Belgium Hasselt Hasselt
AZ Nikolaas - Campus Sint-Niklaas Moerland Deleu Ines Belgium Oost-Vlaanderen Sint-Niklaas
CHR de la Citadelle Salmon Jean-Paul Belgium Liège Liège
AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology Bols Alain Belgium West-Vlaanderen Brugge
AZ Groeninge - Campus Loofstraat Borms Marleen Belgium West-Vlaanderen Kortrijk
AZ Damiaan D'Hondt Randal Belgium West-Vlaanderen Oostende
H？pital Erasme Luce Sylvie Belgium Brussels Capital Region Bruxelles
Sint-Elisabethziekenhuis Pelgrims Gino Belgium Antwerpen Turnhout
AZ Glorieux Verschuere Johan Belgium Ronse Ronse
Jan Ypermanziekenhuis Geldhof Kurt Belgium West-Vlaanderen Ieper
SHATOD-Sofia District Koynova Tatyana Bulgaria Sofia Sofia
Complex Oncology Center Petrov Petar Bulgaria Plovdiv Plovdiv
Specialised Hospital of Active Treatment in Oncological Dise Popov Vasil Bulgaria Varna Varna
MHAT Nadezhda Timcheva Constanta Bulgaria Sofia-Grad Sofia
Complex Oncology Center Tomova Antoaneta Bulgaria Plovdiv Plovdiv
Affinity Research Limited Turnquest Theodore Bahamas Nassau Nassau
Southlake Regional Health Centre Kassam Farrah Canada Ontario Newmarket
Cha-St-Sacrement Desbiens Christine Canada Quebec Quebec City
H？tel Dieu de Lévis Couture Felix Canada Quebec Levis
University Health Network (UHN) - Princess Margaret Hospital Sridhar Srikala Canada Ontario Lübeck
Centre Hospitalier de l’Université de Montréal (CHUM) - Oncology Ayoub Jean-Pierre Canada Montreal Montreal
H？pital Maisonneuve-Rosemont Centre de Recherche Sideris Lucas Canada Montreal Montreal
Hospital Sacre-Coeur de Montreal Lesperance Bernard Canada Quebec Montreal
London Regional Cancer Center Vandenberg Theodore Canada Ontario London
Humber River Hospital Wilson Jonathan Canada Ontario Toronto
Cross Cancer Institute Joy Anil Canada Edmonton Edmonton
R.S. McLaughlin Durham Regional Cancer Centre Chang Jose Canada Ontario Oshawa
Saint Boniface General Hospital Grenier Debjani Canada Manitoba Winnipeg
Vancouver Cancer Centre Chia Stephen Canada British Columbia Vancouver
Jack Ady Cancer Centre Imbulgoda Amal Canada Lethbridge Lethbridge
Spital Thun Rauch Daniel Switzerland Thun Thun
Tumor Center Popescu Razvan Switzerland Aargau (de) Aarau
Kantonsspital Olten [Onkologie] Mingrone Walter Switzerland Olten Olten
Oncomedica S.A IMAT Gonzalez Fernandez Manuel Colombia Monteria Monteria
Oncologos del Occidente Rojas Gustavo Colombia Pereira Pereira
Clinica del Country Franco Sandra Colombia Bogotá Bogotá
Nemocnice Jihlava, p.o. Benesova Vera Czech Republic Jihlava Jihlava
Nemocnice Na Plesi s.r.o. Jirsova Katerina Czech Republic Nova Ves pod Plesi Nova Ves pod Plesi
MULTISCAN, s.r.o. Vanasek Jaroslav Czech Republic Pardubice Pardubice
Masarykuv onkologicky ustav Petrakova Katarina Czech Republic Brno-město Brno
Fakultni nemocnice v Motole Prausova Jana Czech Republic Praha 5 Praha 5
Fakultni nemocnice Brno Bednarik Otakar Czech Republic Brno-město Brno
Praxis für interdisziplin？re Onkologie & H？matologie Marschner Norbert Germany Baden-Württemberg Freiburg
Onkologische Gemeinschaftspraxis am Bethanien Krankenhaus Tesch Hans Germany Hessen Frankfurt
Universit？tsklinikum Düsseldorf Vesper Anne Germany Düsseldorf Düsseldorf
Oncologianova GmbH-Innovationen Overkamp Friedrich Germany Nordrhein-Westfalen Recklinghausen
Klinikum Oldenburg Koehne Claus-Henning Germany Oldenburg Oldenburg
University Hospital Heidelberg Schneeweiss Andreas Germany Heidelberg Heidelberg
Unikl. Schleswig-Holstein - Lübeck Liedtke Cornelia Germany Lübeck Lübeck
Dr. Horst Schmidt Klinik GmbH Cordes Tatjana Germany Wiesbaden Wiesbaden
Universitaetsklinikum Tuebingen Grischke Eva-Maria Germany Baden-Württemberg Tübingen
Frauenarzt-Zentrum-Zehlendorf Graffunder Gerd Germany Berlin Berlin
Sana Klinikum Offenbach Jackisch Christian Germany Offenbach Offenbach
Gyn？kologische Arztpraxis Schilling Joerg Germany Berlin Berlin
Facharzt fuer Frauenheilkunde Gynaekologisch-Onkologische P Lück Hans-Joachim Germany Hannover Hannover
Onkolog. Gemeinschaftspraxis Abenhardt Wolfgang Germany Bayern Muenchen
Luisenkrankenhaus GmbH Rezai Mahdi Germany Düsseldorf Düsseldorf
Marien Hospital Hackmann John Germany Witten Witten
Vejle Sygehus Jakobsen Erik Denmark South Denmark Vejle
Hillerod Hospital Dan？ Hella Denmark Hillerod Hillerod
Roskilde Sygehus Vestlev Peter Denmark Zeeland Roskilde
Sydvestjysk Sygehus Esbjerg Jakobsen Erik Denmark Esbjerg Esbjerg
Odense Universitetshospital - Oncology Cold S？ren Denmark Odense Odense
Oncology Department, Aarhus Universitets Hospital Langkjer Sven Denmark Central Jutland Aarhus N
Sonderborg Sygehus Peric Jana Denmark Sonderborg Sonderborg
Aalborg Universitetshospital Luczak Adam Denmark Aalborg Aalborg
Rigshospitalet - Oncology Ejlertsen Bent Denmark Capital Copenhagen
N？stved Sygehus Glavicic Vesna Denmark N？stved N？stved
Herlev Hospital -The Experimental Cancer Therapy Unit Zambrano-Quispe Oscar Denmark Herlev Herlev
Hospital Universitario Fundación Alcorcón Olier Clara Spain Alcorcon Alcorcon
Hospital Universitario Ramón y Cajal Martinez Já？ez Noelia Spain Madrid Madrid
Hospital Universitario Puerta de Hierro Majadahonda Cubedo Cervera Ricardo Spain Madrid Majadahonda
Fundación Instituto Valenciano de Oncología Ruiz Simón Amparo Spain Valencia Valencia
Hospital Universitario Virgen del Rocio Ruiz Borrego Manuel Spain Andalucía Sevilla
Complejo Hospitalario de Jaén Lomas Garrido Maria Spain Jaén Jaén
H.U.Pta.del Mar Baena Canada Jose Spain Cádiz Cádiz
Hospital Universitario Reina Sofía De La Haba Rodriguez Juan Rafael Spain Córdoba Córdoba
H.U. Virgen de la Victoria Sanchez Mu？oz Alfonso Spain Málaga Málaga
H.U.M. de Terrassa González Sonia Spain Barcelona Terrassa
H.G.U.Guadalajara Cassinello Espinosa Javier Spain Guadalajara Guadalajara
Institut Catalá d′Oncología (I.C.O.) Pernas Simon Sonia Spain Barcelona L′Hospitalet de Llobregat
H. Prov. de Zamora Alvarez Gallego Jose Valero Spain Zamora Zamora
H. de Basurto Martínez del Prado Purificación Spain Vizcaya Basurto Bilbao
H.G.U. de Elche Rodríguez Lescure Alvaro Spain Alicante Elche
Hospital Universitario Son Espases Perelló Martorell Antonia Spain Baleares Palma de Mallorca
C.S. de Terrassa Arcusa Angels Spain Barcelona Terrassa
H.U. Nuestra Se？ora de la Candelaria García Alonso Mirta Spain Sta. Cruz De Tenerife Sta. Cruz De Tenerife
Hospital Madrid Norte Sanchinarro Vega Alonso Estela Spain Madrid Sanchinarro
C.H. Provincial de Castellón Martínez de Due？as Eduardo Spain Castellón Castellón de la Plana
Hospital Clínico San Carlos García Sáenz José Spain Madrid Madrid
Centro Oncológico de Galicia Ramos Vázquez Manuel Spain A Coru？a A Coru？a
Hospital Clinic de Barcelona Arance Fernández Ana Spain Barcelona Barcelona
ICO-Hospital Universitari de Girona Dr. Josep Trueta del Barco Berron Sonia Spain Girona Girona
Hospital Universitari Germans Trias i Pujol Cirauqui Beatriz Spain Barcelona Badalona
H.U. Arnau de Vilanova Morales Murillo Serafín Spain Lleida Lleida
Hospital Universitario Miguel Servet Antón Torres Antonio Spain Zaragoza Zaragoza
Hospital General Universitario Gregorio Mara？ón Martín Jiménez Miguel Spain Madrid Madrid
Hospital San Pedro de Alcántara González Santiago Santiago Spain Cáceres Cáceres
Hospital Clínico Universitario de Valencia Bermejo de las Heras Bego？a Spain Valencia Valencia
Hospital Universitario de Canarias Batista Jose Spain Santa Cruz de Tenerife San Cristóbal de La Laguna
Hospital Virgen de la Salud Chacón López-Mu？iz José Spain Toledo Toledo
H. de Barbastro Florian Gerico Jesus Spain Barbastro Barbastro
Hospital Universitario Vall d'Hebrón Bellet Ezquerra Meritxell Spain Barcelona Barcelona
Institut De Cancerologie Gustave Roussy - Cancer Medicine Delaloge Suzette France Villejuif Villejuif
Centre Oscar Lambret - S？？nologie Vanlemmens Laurence France Lille Lille
Centre Georges Francois Leclerc - service d'oncologie m？？dicale Coudert Bruno France C？te-d'Or Dijon
Centre de Lutte Contre le Cancer (CLCC) Thery Jean-Christophe France Rouen Rouen
Polyclinique Francheville - Oncologie et Radioth？？rapie Cany Laurent France Perigueux Perigueux
Institute de Cancerologie de la Loire Jacquin Jean-Philippe France Saint Priest En Jarez Saint Priest En Jarez
Hopital Paul Brousse Machover David France Villejuif Villejuif
Centre Hospitalier De Versailles - Hopital Andre Mignot Mayeur Didier France Yvelines Le Chesnay
Clinique Sainte Anne - Radiotherapie Dourthe Louis-Marie France Alsace Strasbourg
CHU Bretonneau - Centre Henry Kaplan Vegas Hélène France Indre-et-Loire Tours
Centre de Lutte Contre le Cancer (CLCC) Levy Christelle France Calvados Caen cedex 05
CHU Strasbourg - H？？matologie et Oncologie Bergerat Jean-Pierre France Alsace Strasbourg
Hopital Saint Louis Espie Marc France PARIS Cedex 10 PARIS Cedex 10
Institut De Canc？？rologie De La€？Ouest - Ren？？ Gauducheau - Oncologie Medicale Bourbouloux Emmanuelle France Loire-Atlantique Saint Herblain
Hopital La Piti？？-Salp？？tri？¨re - Oncologie M？？dicale Spano Jean-Philippe France Paris cedex 13 Paris cedex 13
H？′pital Saint-Andr？？ - Service d'Oncologie Medicale Trufflandier Nathalie France Gironde Bordeaux Cedex
Clinique Mutualiste de la€？Estuaire - Oncologie Medicale - Cancerolo Delecroix Valerie France Loire-Atlantique Saint Nazaire
Centre De Lutte Contre Le Cancer - Institut Curie - D？？partement d'Oncologie M？？dica Cottu Paul-Henri France Paris Paris
CHU Michallon - Hopital Nord - Canc？？rologie Et H？？matologie Mousseau Mireille France Isère Grenoble
Centre Jean Perrin Mouret-Reynier Marie-Ange France Clermond Ferrand Clermond Ferrand
Weston Park Hospital Winter Matthew The United Kingdom Sheffield Sheffield
Singleton Hospital Rolles Martin J The United Kingdom Swansea Swansea
North Wales NHS Trust - Glan Clwyd Hospital Bishop Jill The United Kingdom Rhyl Rhyl
Nottingham University Hospital - Oncology Khan Sarah The United Kingdom Nottingham Nottingham
Southend University Hospital NHS Foundation Trust Algurafi Hafiz The United Kingdom Westcliff on Sea Westcliff on Sea
St Bartholomew's Hospital, Barts Health NHS Trust Conibear John The United Kingdom London London
Charing Cross Hospital Cleator Susan The United Kingdom London London
Leeds Cancer Centre at St. James's University Hospital - Oncology Perren Timothy The United Kingdom Leeds Leeds
Leicester Royal Infirmary-University Hospitals of Leicester Ahmed Samreen The United Kingdom Leicester Leicester
Norfolk & Norwich University Hospitals Epurescu Daniel The United Kingdom Norwich Norwich
Guys and St. Thomas Hospital - Oncology？& Haematology Clinical Trials Mansi Janine The United Kingdom London London
The Christie NHS Foundation Trust - Medical Oncology Armstrong Anne The United Kingdom Manchester Manchester
General Hospital of Chania Ag. Georgios Bompolaki Iliada Greece Chania Chania
Uni General Hospital Of Alexandroupolis Kakolyris Stylianos Greece Evros Alexandroupolis
Kliniki Thermi Fountzilas George Greece Thessaloniki Thessaloniki
University of Crete - University General Hospital of Herakli Mavroudis Dimitrios Greece Heraklion Crete Heraklion Crete
University General Hospital Of Patras - Dpt Of Medicine, Division Oncology Kalofonos Haralabos Greece Patras Patras
Hippokration Hospital Athens Pectasidis Dimitrios Greece Athens Athens
Unimed Medical Institute - Clinical Oncology Chow Louis 中国 香港 香港
Queen Mary Hospital - Medicine Yau Chung Cheung Thomas 中国 香港 香港
Queen Mary Hospital Chiu Joanne 中国 香港 香港
Tuen Mun Hospital 吴廷英 中国 香港 香港
Klini？ki bolni？ki centa Osijek - Odjel za radioterap. i onkolo. - Odjel za radioterap. i onkolo. Flam Josipa Croatia Osijek Osijek
Klinicki bolnicki centar Zagreb - Oncology department Bilic Ivan Croatia Grad Zagreb Zagreb
Opca bolnica Varazdin Vojnovic Zeljko Croatia Vara？dinska ？upanija VARAZDIN
Klinicki bolnicki centar Separovic Robert Croatia Zagreb Zagreb
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór Polya Zsofia The Republic of Hungary Szabolcs-Szatmár-Bereg Nyíregyháza
Országos Onkológiai Intézet Lang Istvan The Republic of Hungary Budapest Budapest
Bács-Kiskun Megyei Kórház Horvath Zsolt The Republic of Hungary Kecskemét Kecskemét
F？városi ？nkormányzat Szent Imre Kórház Nagy Zsuzsa The Republic of Hungary Budapest Budapest
Békés Megyei K？zponti Kórház Pándy Kálmán Tagkórház Pikó Béla The Republic of Hungary Békés Gyula
Somogy Megyei Kaposi Mór Oktató Kórház - Onkologiai Centrum Somogyiné Ezer éva The Republic of Hungary Kaposvár Kaposvár
Semmelweis Egyetem Dank Magdolna The Republic of Hungary Budapest Budapest
Csolnoky Ferenc Kórház Simo Erzsebet The Republic of Hungary Veszprém Veszprém
Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktatók Büdi László The Republic of Hungary Borsod-Abaúj-Zemplén Miskolc
Kaplan Medical Center - Oncology Division Efrat Noa The State of Israel Rehovot Rehovot
Soroka University Medical Center - Gynecological Oncology Unit, Department of Obstetrics and Gynecology Geffen David The State of Israel Beer Sheva Beer Sheva
The Chaim Sheba Medical Center - Institute of Oncology Kaufman Bella The State of Israel Tel Hashomer Tel Hashomer
Rambam Health Care Campus Drumea Karen The State of Israel Haifa Haifa
Azienda Ospedaliera S. Maria di Terni - MD Degenza Oncologica Sabatini Silvia Italy Umbria Terni
Università Campus Bio-Medico di Roma Tonini Giuseppe Italy Roma Roma
ASST Bergamo Ovest, Ospedale Treviglio Caravaggio di Trevigl Petrelli Fausto Italy Bergamo Treviglio
Fondazione Pascale, IRCCS, Istituto Nazionale dei Tumori Nuzzo Francesco Italy Napoli Napoli
IRCCS Istituto Oncologico Veneto di Padova Falci Cristina Italy Padova Padova
Regina Elena, Istituto Nazionale dei Tumori, IFO, IRCCS Cognetti Francesco Italy Roma Roma
AOU San Luigi Gonzaga Gorzegno Gabriella Italy Torino Orbassano
AO S.G. Moscati - Avellino Gridelli Cesare Italy Avellino Avellino
SO S.Chiara, AOU Pisana - Oncologia 2 Falcone Alfredo Italy Pisa Pisa
Azienda Mater Domini Tassone Pierfrancesco Italy Calabria Catanzaro
Azienda Ospedaliera Cartenì Giacomo Italy Napoli Napoli
Azienda Ospedaliera Bianchi Melacrino Morelli Reggio Calabri Maisano Roberto Italy Reggio Calabria Reggio Calabria
Ospedale Belcolle Viterbo Ruggeri Enzo Italy Viterbo Viterbo
Azienda Unita Sanitaria Locale (ASL) - Ospedale SS.Trinita - Magnolfi Emanuela Italy Sora Sora
PO G.Rodolico, AOU Policlinico-Vittorio Emanuele di Catania Soto Parra Hector Jose Italy Catania Catania
Ospedale San Gerardo-ASST Monza Bidoli Paolo Italy Lombardia Monza
Ospedale A.Perrino, SO Summa-Perrino, ASL Brindisi - Oncologia - Farmacia Cinieri Saverio Italy Brindisi Brindisi
Istituto Oncologico del Mediterraneo Giuffrida Dario Italy Catania Viagrande (Catania)
Hakuaikai Sagara Hospital - Breast Surgery 相良安昭 Japan Kagosima Kagosima
Saitama Cancer Center - Breast Oncology 井上賢一 Japan Saitama Kitaadachi-gun
National Hospital Organization - Osaka National Hospital - Surgery 増田慎三 Japan Osaka Osaka
National Kyushu Cancer Center - Breast Oncology Tokunaga 徳永 Eriko えり子 Japan Hukuoka [Fukuoka] Fukuoka
Hyogo Cancer Center - Breast Surgery Takao Shintaro Japan Hy？go [Hyogo] Akashi
JCHO Kurume General Hospital - Surgery Tanaka 田中 Maki 眞紀 Japan Hukuoka [Fukuoka] Kurume
Niigata Cancer Center Hospital - Breast Surgery Sato 佐藤 Nobuaki 信昭 Japan Niigata Niigata
Hiroshima City Hiroshima Citizens Hospital Ohtani 大谷 Shoichiro 彰一郎 Japan Hirosima [Hiroshima] Hiroshima
Chiba Cancer Center - Breast Surgery Miyaki 味八木 Toshiko 寿子 Japan Tiba [Chiba] Chiba
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital - Breast Endocrine Surgery Aruga 有賀 Tomoyuki 智之 Japan Bunkyo-ku Bunkyo-ku
Aichi Cancer Center Hospital - Clinical Oncology Iwata 岩田 Hiroji 広治 Japan Aiti [Aichi] Nagoya
National Cancer Center Hospital East - Breast Medical Oncology Mukai 向井 Hirofumi 博文 Japan Tiba [Chiba] Kashiwa
Osaka International Cancer Institute Nakayama 中山 Takahiro 貴寛 Japan Osaka Osaka
Osaka University Hospital - Breast and Endcrine Surgery Kim 金 Seung-Jin 昇晋 Japan saka [Osaka] Suita
Kyoto University Hospital - Breast Surgery Sato 佐藤 Fumiaki 史顕 Japan Ky？to [Kyoto] Kyoto
Hokkaido Cancer Center - Breast Endocrine Surgery Takahashi 高橋 Masato 將人 Japan Sapporo Sapporo
Tokai University Hospital Niikura 新倉 Naoki 直樹 Japan Kanagawa Isehara
Kanagawa Cancer Center - Breast and Endocrine Surgery Suganuma 菅沼 Nobuyasu 伸康 Japan Kanagawa Yokohama
Jichi Medical University Hospital - Breast Surgery Sakuragi 櫻木 Masako 雅子 Japan Totigi [Tochigi] Shimotsuke
The Cancer Institute Hospital of JFCR - Medical Oncology Ito 伊藤 Yoshinori 良則 Japan T？ky？ [Tokyo] Koto-Ku
Kumamoto City Hospital Yamasaki Hiroshi Japan Kumamoto Kumamoto
Shizuoka Cancer Center Watanabe Junichiro Japan Sunto-gun Sunto-gun
Korea University Anam Hospital - Oncology / Hematology Park Kyong Hwa Korea Seoul Seoul
Samsung Medical Center - Hematology-Oncology Im ？ Young-Hyuck ？？ Korea Seoul Seoul
Asan Medical Center - Oncology Kim ？ Sung Bae ？？ Korea Seoul Seoul
Seoul National University Hospital Im ？ Seock-Ah ？？ Korea Seoul Seoul
National Cancer Center - Breast Cancer Park ？ In Hae ？？ Korea Goyang Goyang
National Cancer Institute Ciceniene Audrone Lithuania Vilniaus Apskritis Vilnius
The Hospital of Lithuanian University of Health Sciences Kauno klinikos Juozaityte Elona Lithuania Kaunas Kaunas
Nucleo de Especialidades Oncologicas Sanchez Llamas Benito Mexico Guadalajara Guadalajara
University Clinic of Radiotherapy and Oncology Smichkoska Snezhana Macedonia Skopje Skopje
Sir Anthony Oncology Center Brincat Stephen Malta Floriana MSIDA
University Malaya Medical Centre Zarina Bustam Anita Malaysia Wilayah Persekutuan Kuala Lump Kuala Lumpur
Apeldoorn Gelre Ziekenhuis Madretsma G.S. Netherlands Apeldoorn Apeldoorn
Ziekenhuis Amstelland Van Groeningen RETIRED Cees J. Netherlands Amstelveen Amstelveen
Maxima Medisch Centrum Dercksen Marcus Netherlands Eindhoven Eindhoven
Amphia Ziekenhuis - Locatie Langendijk Breda ten Tije Albert Netherlands Breda Breda
Stichting Zuyderland Medisch Centrum Erdkamp Franciscus Netherlands Limburg Sittard-Geleen
Franciscus Vlietland Ruit J. Netherlands Schiedam Schiedam
Haga ziekenhuis Portielje Johanna Netherlands The Hague The Hague
Auckland City Hospital - Oncology Bashford Anna New Zealand Auckland Auckland
Clinica San Borja Bermudez Vanessa Peru Lima Lima
Bialostockie Centrum Onkologii im. M.Sklodowskiej-Curie Wojtukiewicz Marek Poland Podlaskie Bialystok
Olsztynski Osrodek Onkologiczny Suszko - Kazarnowicz Malgorzata Poland Olsztyn Olsztyn
Szpital Uniwersytecki w Krakowie Krzemieniecki Krzysztof Poland Krakow Krakow
Szpitale Pomorskie Sp. z o.o. Danielewicz Iwona Poland Pomorskie Gdynia
Uniwersyteckie Centrum Kliniczne Jassem Jacek Poland Gdansk Gdansk
MAGODENT Sp. z o.o. Szpital Onkologiczno-Kardiologiczny Grzeda Lukasz Poland Mazowieckie Warszawa
Centrum Onkologii im. prof. Franciszka ？ukaszczyka Chmielowska Ewa Poland Kujawsko-pomorskie Bydgoszcz
SPZOZ Szpital Wojewodzki im.Sw.Lukasza Banas Renata Poland Tarnow Tarnow
Wojewodzkie Centrum Szpitalne Kotliny Jelenigorskiej Wozniak Katarzyna Poland Dolnoslaskie Jelenia Gora
SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii Czerniawska-Meler Malgorzata Poland Warminsko-mazurskie Olsztyn
Institutul Oncologic Eniu Alexandru Romania Cluj Cluj-Napoca
Oncolab Lungulescu Dan Stelian Stefan Romania Craiova Craiova
Spitalul Universitar de Urgenta Bucuresti Iorga Polixenia Romania Bucuresti Bucuresti
National Cancer Centre Singapore Yap Yoon Sim Singapore Central Singapore Singapore
Clinical Centre Nis, Clinic of Hematology and Clinical Immu Filipovic Sladjana Serbia Ni？avski okrug Nis
Institute for Oncology and Radiology of Serbia Tomasevic Zoran Serbia Belgrade Belgrade
POKO Poprad, s.r.o. Kakalejcik Marian Slovakia Pre？ovsky kraj Poprad
Onkologicky ustav Sv. Alzbety, s.r.o. Mikulova Milada Slovakia Bratislava Bratislava
Vychodoslovensky onkologicky ustav, a.s. Wagnerova Maria Slovakia Kosice Kosice
Sk？nes Universitetssjukhus Loman Niklas Sweden Sk？ne l？n [SE-12] Lund
Sk？nes Universitetssjukhus Malm？ Loman Niklas Sweden Malm？ Malm？
Gaziantep Universitesi Cinkir Havva Turkey Gaziantep Gaziantep
Ege University Medical Faculty Gokmen Erhan Turkey Izmir Izmir
Gazi University Medical Faculty Hospital Medical Oncology Tahtaci Gozde Turkey Ankara Ankara
Dokuz Eylul University Medical Faculty Somali Isil Turkey Izmir Izmir
Hacettepe University Institute of Cancer Aksoy Sercan Turkey Ankara Ankara
Istanbul University Cerrahpasa Medical Faculty Ozguroglu Mustafa Turkey Istanbul Istanbul
Marmara University Pendik Training & Research Hospital Yumuk Perran Turkey Istanbul Istanbul
Istanbul University Cerrahpasa Medical Faculty Saip Pinar Turkey Istanbul Capa/Istanbul
Dr Abdurrahman Yurtaslan Ankara Oncology Training And Resear Alkis Necati Turkey Ankara Ankara
National Taiwan University Hospital - Oncology Lu 盧 Yen-Shen 彥伸 中国 Taipei City Taipei City
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Breast Surgery Chen 陳 Shin-Cheh 訓徹 中国 Taoyuan Taoyuan
Kaohsiung Medical University - Chung-Ho Memorial Hospital - Division of Pulmonary and Crit Hou 侯 Ming-Feng 明鋒 中国 Kaohsiung Kaohsiung
North Mississippi Hematology & Oncology Assoc, Ltd Montgomery Charles Weinacker America Mississippi Tupelo
Avera Medical Group Krie Amy America South Dakota Sioux Falls
Center for Surgical & Speciality Care, Redlands Community Hospital, Oncology Clinical Trials Ibrahim Emad America California Redlands
Facey Medical Foundation Dekker Albert America California Mission Hills
St. Luke’s University Health Network？？？？？ ？？ Belman Neil America Pennsylvania Easton
Florida Cancer Specialists and Research Institute Dickerson Laura America Florida Gainesville
MetroHealth Medical Center - MetroHealth's Cancer Care Cente Hergenroeder Paul America Ohio Cleveland
Hematology Oncology of Indiana Birhiray Ruemu America Indianapolis Indianapolis
Rutland Regional Medical Center Eisemann Allan America Vermont Rutland
Florida Cancer Specialists Mace Joseph America Florida St. Petersburg
Saint Barnabas Medical Center - Cancer Center Conde Miguel America New Jersey Livingston
Signal Point Clinical Research Center, LLC Vrindavanam Nandagopal America Ohio Middletown
Coastal Bend Cancer Center Manalo Yvonne America Texas Corpus Christi
East Texas Medical Center Cancer Institute Droder Robert America Texas Tyler
Cancer Specialists of South Texas, P.A. Mahmood Aftab America Texas Corpus Christi
Hematology Oncology North Shore Kaplan Edward America Illinois Skokie
Oncology and Hematology Specialists, P.A. - Denville Abbasi Rashid America New Jersey Denville
Hematology/Oncology Associates of Treasure Cove Iannotti Nicholas America Florida Port Saint Lucie
Monongahela Valley Hospital - Oncology Zahalsky Andrew America Monongahela Monongahela
Southwestern Vermont Regional Cancer Center Vernon Matthew America Vermont Bennington
Santee Hematology Oncology Clowney Billy America South Carolina Sumter
Jefferson University Hospitals - Kimmel Cancer Center Jaslow Rebecca America Pennsylvania Philadelphia
Breastlink Medical Group Link John America California Santa Ana
Springfield Clinic, LLP Singh Preet America Illinois Springfield
South Carolina Cancer Specialists Thomas Gary America Hilton Head Island Hilton Head Island
Broward General Medical Center Maini Archana America Florida Fort Lauderdale
Wenatchee Valley Hospital & Clinics Smith Julie America Washington Wenatchee
CTCA at Midwestern Regional Medical Center Ahn Eugene America Illinois Zion
Orchard Healthcare Research Inc. Oliff Ira America Illinois Skokie
North East Oncology Associates - Concord Steffens Thomas America North Carolina Concord
Medical Hematology & Oncology Associates Heyer David America Virginia Fairfax
Albert Einstein Medical Center Morginstin Mark America Pennsylvania Philadelphia
West Virginia University - Mary Babb Randolph Cancer Center Craig Michael America Morgantown Morgantown
M. Francisco Gonzalez, MD PA Gonzalez Manuel America South Carolina Sumter
Ventura County Hematology-Oncology Specialists - Oxnard Kong Lynn America Oxnard Oxnard
Cedars-Sinai Medical Group (CSMG) Vaysburd Marina America California Beverly Hills
Oregon Health & Science University - Knight Cancer Institute Kemmer Kathleen America Oregon Portland
The Simmons Cooper Cancer Center Institute at SIU Mocharnuk Robert America Illinois Springfield
Jersey Shore University Medical Center Nahum Kenneth America Nahum Kenneth Neptune
Fowler Family Center for Cancer Care Nixon David America Arkansas Jonesboro
Temple University Hospital Cancer Center Padmanabhan Aruna America Pennsylvania Philadelphia
ProHEALTH CARE Associates, LLP Citron Marc America New York Lake Success
Florida Medical Clinic, P.A. McDonough Richard America Florida Zephyrhills
Erlanger Health System Schlabach Larry America Tennessee Chattanooga
Southeast Nebraska Hematology & Oncology Consultants, PC Green Nathan America Nebraska Lincoln
University of Texas Southwestern Medical Center Haley Barbara America Texas Dallas
Munster Community Hospital Kassar Mohamad America Indiana Munster
Cookeville Regional Medical Center Sidrys Algis America Cookeville Cookeville
Cancer Care Specialists of Central Illinois, S.C. (CCSCI) - Cancer Care Center of Decatur Wade III James America Illinois Decatur
Birmingham Hematology and Oncology Associates Gore Ira America Alabama Birmingham
Thompson Cancer Survival Center Patel Jashmin America Tennessee Knoxville
Vanderbilt - Ingram Cancer Center Mayer Ingrid America Tennessee Nashville
Washington Cancer Institute (WCI) Swain Sandra America District of Columbia Washington
Montana Cancer Institute Foundation Beatty Patrick America Montana Missoula
Hematology and Oncology Specialists Cosgriff Thomas America Louisiana Metairie
Desert Hematology Oncology Medical Group Inc. Dreisbach Luke America California Rancho Mirage
UMass Memorial Medical Center Edmiston Kathryn America Massachusetts Worcester
York Hospital - Oncology Treatment Center - Oncology McLaughlin Marilyn America Maine York
Oncology Specialists, SC Hallmeyer Sigrun America Illinois Park Ridge
South Texas Oncology & Hematology, PA Rodriguez Gladys America San Antonio, San Antonio,
Northwest Medical Specialties PLLC Senecal Francis Mark America Washington Tacoma
Great Plains Regional Medical Center Pasam Avanish America North Platte North Platte
Northern Utah Associates Hansen Vincent America Utah Ogden
Guthrie Medical Group, PC - On Lowry Philip America Pennsylvania Sayre
Medical Specialty Associates Pawl Lawrence America Michigan Grand Rapids
North Broward Medical Center Faig Douglas America Florida Deerfield Beach
Marin Cancer Care Lucas Jennifer America California Greenbrae
The Christ Hospital Cancer Research Bhandari Manish America Ohio Cincinnati
Ashland Bellefonte Cancer Center Jain Kirti America Kentucky Ashland
Wheeling Hospital Shinn Lowell America West Virginia Wheeling
Helen Diller Family Comprehensive Cancer Center Chien Amy Jo America San Francisco San Francisco
Northern Arizona Hematology & Oncology Associates Roberts Michael America Arizona Sedona
Utah Cancer Specialists Kendall Stephen America Utah Salt Lake City
Texas Oncology,P.A. - Bedford - Oncology Anderson Thomas America Bedford Bedford
Texas Oncology - Round Rock Patt Debra America Texas Round Rock
Texas Oncology, P.A. Cairo Michelina America Texas Houston
Warren Alpert Medical School Witherby Sabrina America Rhode Island Providence
USO Texas Oncology - Tyler Richards Donald America Texas Tyler
FL Cancer Research Institute Tan-Chiu Elizabeth America Florida Plantation
Central Maine Healthcare Corp Erickson Nicholette America Lewiston Lewiston
Providence Portland Medical Center Conlin Alison America Oregon Portland
Mercy Hospital Inhorn Roger America Maine Portland
Arizona Oncology Associates - Tucson - Rudasill Road Brooks Donald America Arizona Tucson
Massachusetts General Hospital-Gillette Center for Women's C Moy Beverly America Massachusetts Boston
Summit Medical Group Papish Steven America New Jersey Florham Park
Washington University School of Medicne Neuromuscular Division Department of neurology Box 8111 - Research Bose Ron America Missouri St. Louis
Cooper University Hospital Somer Robert America New Jersey Voorhees
Minnesota Oncology Hematology Larson Timothy America Minnesota Minneapolis
Practice Dr Clyde Jones Jones Clyde America Tennessee Germantown
Samaritan Center For Health Research - Oncology Hufnagel David America Oregon Corvallis
New York University Clinical Cancer Center Novik Yelena America New York New York
Mid Dakota Clinic 9th & Rosser Main Clinic Rao Vijay America North Dakota Bismarck
Anniston Oncology, P.C. Spremulli Ellen America Alabama Anniston
Phoebe Putney Health System-Phoebe Sumter Medical Center Jani Chirag America Georgia Albany
Massachusetts General Hospital Moy Beverly America Massachusetts Boston
Massachusetts General Hospital Moy Beverly America Massachusetts Boston
Piedmont Cancer Institute, P.C. - Oncology Assikis Vasileios (Vasily) America Georgia Atlanta
Texas Oncology, P.A. Prakash Sucharu America Texas Paris
Innovative Medical Research of South Florida Saltzman Marc America Florida Aventura
New York Cancer and Blood Specialists Volterra Fabio America New York Bronx
Geneva Foundation Delmas Andrew America Washington Tacoma
Trinitas Regional Medical Center-Trinitas Comprehensive Canc Capo Gerardo America New Jersey Elizabeth
Hematology/Oncology Clinic, LLP Castine Michael America Louisiana Baton Rouge
Wayne State University-Barbara Ann Karmanos Cancer Institute Flaherty Lawrence America Michigan Detroit
El Paso Cancer Treatment Center - West Rivera Ragene America El Paso El Paso
University Hospitals Cleveland Medical Center Silverman Paula America Ohio Cleveland
Texas Oncology-Denton South Jain Sharad America Texas Denton
US Oncology - Virginia Cancer Specialists, PC Denduluri Neelima America Virginia Fairfax
Texas Oncology, PA Osborne Cynthia America Texas Dallas
Compass Oncology - Rose Quarter Smith John America Oregon Portland
Texas Oncology-Garland Gupta Manish America Texas Garland
Nashville Breast Center Whitworth Pat America Nashville Nashville
All Saints Healthcare - All Saints Medical Group Choi Young America Wisconsin Racine
Mercy Medical Research Institute Snider Jessica America Missouri Springfield
Ocala Oncology Center Balaraman Rama America Florida Ocala
Mercy Clinic Oncology and Hematology Bova Abby America Oklahoma Oklahoma City
St Joseph Heritage Healthcare Anderson Ian America California Santa Rosa
Augusta Oncology Associates - Sebastian Way David Alice America Georgia Augusta
Medical University of South Carolina Hollings Cancer Center Brescia Frank America South Carolina Charleston
Texas Oncology - Fort Worth 12th Ave Ruxer Robert America Texas Fort Worth
Adventist Health Glendale Shirinian Mihran America California Glendale
Cancer Care Centers Of South Texas Wilks Sharon America Texas San Antonio
Cancer and Hematology Centers of Western Michigan O'Rourke Timothy America Michigan Grand Rapids
Arizona Oncology Associates- Biltmore Cancer Center Roberts Michael America Arizona Phoenix
Hawaii Pacific Health Research Institute Okazaki Ian America Hawaii Honolulu
Portneuf Medical Center Francisco Michael America Pocatello Pocatello
Cancer Care Northwest, PS Nichols Joni America Washington Spokane
Texas Oncology - Waco Encarnacion Carlos America Texas Waco
Cancer Center of Central Connecticut Byeff Peter America Plainville Plainville
St Joseph's Oncology Abou-Jawde Rony America St. Joseph St. Joseph
McLeod Oncology and Hematology Associates Bajaj Rajesh America South Carolina Florence
Long Beach Memorial Medical Center Nguyen Bichlien America Long Beach Long Beach
The Valley Hospital Luckow Pavilion Rakowski Thomas America New Jersey Paramus
Kaiser Permanente Northwest Rarick Mark America Oregon Portland
Thomas Niederman, M.D. Niederman Thomas America Boynton Beach Boynton Beach
Orchard Healthcare Research Inc. Oliff Ira America Illinois Skokie
Duke University Medical Center Kimmick Gretchen America North Carolina Durham
Cancer Centers of Florida Flores Maria Regina America Orlando Orlando
UPC Pinnacle Health Cancer Institute Lee Theresa America Pennsylvania Harrisburg
Cascade Cancer Center Kohn Aimee America Washington Kirkland
Gynecologic Oncology Associates Micha John America California Newport Beach
Hematology Oncology PC Weinstein Paul America Connecticut Stamford
Sutter Health California Pacific Medical Center Wang Wei America California San Francisco
Park Nicollet Institute Anderson Daniel America Minnesota Saint Louis Park
Medical Arts Associates, Ltd. Porubcin Michael America Illinois Moline
Charleston Hematology Oncology Ellison David America South Carolina Charleston
Gettysburg Cancer Center Shah Satish America Pennsylvania Gettysburg
University of Cincinnati Medical Center Charif Mahmoud America Ohio Cincinnati
Mercy Medical Center Riseberg David America Maryland Baltimore
Pharmaron CPC, Inc. DePetrillo Paolo America Maryland Baltimore
Gemeinschaftspraxis fuer Haematologie und Onkologie Janssen Jan Germany Niedersachsen Westerstede
Haematologisch-onkologische Praxis Dres. Brudler-Heinrich-Ba Heinrich Bernhard Germany Bayern Augsburg
Praxis K. Apel Apel Klaus Germany Erfurt Erfurt
Klinikum der Universit？t München - Campus Innenstadt Harbeck Nadia Germany Bayern München
Sozialstiftung Bamberg Enzinger Hans Martin Germany Bayern Bamberg
St. Marienhospital Seeger Dietmar Germany Vechta Vechta
Klinikum Frankfurt H？chst GmbH - Gynecology M？bus Volker Germany Hessen Frankfurt am Main
Praxis Schwaner und Kollegen Schwaner Ingo Germany Berlin Berlin
Praxisklinik Krebsheilkunde fuer Fraue Klare Peter Germany Berlin Berlin
Klinikum St. Georg/Franziskus von der Assen Albert Germany Georgsmarienhuette Georgsmarienhuette
Gemeinschaftspraxis Dr. Andreas Karcher & Dr. Stefan Fuxius Stefan Germany Heidelberg Heidelberg
Marienhospital Danaei Mahmoud Germany Nordrhein-Westfalen Aachen
Praxis für Frauenheilkunde Anita Prechtl Anita Germany Bayern München
Pius-Hospital Oldenburg Griesinger Frank Germany Oldenburg Oldenburg
Kantonsspital Baden AG Caspar Clemens Switzerland Baden Baden
H.U. Insular de Gran Canaria Vicente Rubio Elena Spain Las Palmas Las Palmas de Gran Canaria

伦理委员会信息

名称 审查结论 审查日期
中国医学科学员肿瘤医院临床研究中心伦理委员 同意 2014-12-30

试验状态信息

试验状态
已完成
目标入组人数
国内: 91 人； 国际: 3850 人；
已入组例数
国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；
实际入组总例数
国内: 49 人 ； 国际: 2840 人；
第一例受试者签署知情同意书日期
国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；
第一例受试者入组日期
国内：2010-07-16；     国际：2009-07-09；
试验终止日期
国内：2019-10-04；     国际：2019-10-04；

临床试验结果摘要

版本号 版本日期

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