阿哌沙班(BMS-562247)包膜片5 mg |进行中-招募完成

登记号
CTR20132406
相关登记号
曾用名
药物类型
化学药物
临床申请受理号
企业选择不公示
适应症
非瓣膜性房颤
试验通俗题目
在Vk拮抗剂治疗失败或不适用的房颤患者中预防卒中研究
试验专业题目
比较阿哌沙班与阿司匹林在维生素K拮抗剂治疗失败或不适用的房颤患者中预防卒中的作用
试验方案编号
CV185-048
方案最近版本号
版本日期
方案是否为联合用药
企业选择不公示

申请人信息

申请人名称
联系人姓名
刘蔚
联系人座机
021-23218416
联系人手机号
联系人Email
Kelly.liu@bms.com
联系人邮政地址
上海市南京西路1717号会德丰广场59楼
联系人邮编
200040

临床试验信息

试验分类
安全性和有效性
试验分期
III期
试验目的
对于患有房颤且至少还有一种卒中危险因素且不适合维生素K拮抗剂治疗或治疗失败的患者,明确阿哌沙班5mg BID(某些特定患者为2.5mg BID[每日二次])在卒中或体循环栓塞复合事件的预防中是否优于ASA(81 - 324 mg QD[每日一次] )
随机化
随机化
盲法
双盲
试验范围
国际多中心试验
设计类型
平行分组
年龄
50岁(最小年龄)至 NA岁(最大年龄)
性别
男+女
健康受试者
入选标准
  • 签署书面知情同意书
  • 筛选当日的12导联ECG确认为永久性,阵发性或持续性房颤
  • 如果筛选时没有房颤,则必须有在入选前6个月内经12导联ECG记录的房颤,或心律长条图或动态心电图上记录的房颤发作时间至少为5分钟。也可采用起搏器或ICD心电图记录AF,但如果只有这种方式记录到AF,则AF的持续时间必须至少为30分钟。
  • 至少存在一种以下卒中危险因素:既往卒中或TIA病史;年龄≥ 75 岁;治疗期间的动脉高血压;糖尿病;心功能衰竭。入选时NYHA分级为2级或2级以上;入选前6个月内记录到的左心室射血分数≤35%
排除标准
  • 性别和生育状况: a)妊娠或哺乳期妇女;b)不愿遵守研究中妊娠试验要求(见7.6.1 妊娠试验要求)或不愿/不能采取可接受的避孕措施的育龄妇女 (WOCBP)
  • 作为排除标准的疾病:a)可逆性原因(如甲状腺中毒症,心包炎)导致的房颤;b)需要手术的瓣膜病变; c)计划在3个月内行房颤消融术
  • 病史和伴随疾病:a)除房颤外,其他需要长期使用抗凝药的状态(如机械心脏瓣膜,静脉血栓形成;也见5.5节伴随治疗); b)过去6个月内有严重出血或有出血高危因素的患者,包括但不限于:活动性消化性溃疡,血小板计数 < 100,000/mm3 或血红蛋白< 10g/dL,最近发作卒中 (过去10 天内),有记录的出血倾向或血液异常;c)目前的酗酒或药物滥用,或导致无法参加研究的心理社会原因;d)严重的合并症,预期寿命<1年
  • 体检和实验室检查结果: a)严重的肾功能不全 (必须计算所有病人的肌酐清除率;任何病人的血肌酐> 2.5 mg/dL [221 umol/L] 或计算的肌酐清除率≤ 25 ml/min必须排除);b)ALT或AST >正常值上限的2倍或总胆红素>正常值上限的 1.5 倍[除非发现另一种导致这种结果的原因(如Gilbert综合征) ]
  • 过敏和药物不良反应:对ASA过敏或有不良反应
  • 禁用药物和/或疗法:a)参加研究时禁止使用的药物见5.5.1节(禁用和/或限制使用的药物);b)要求使用噻吩吡啶类药物[氯吡格雷或噻氯匹定,见5.5.2.1 阿司匹林 (ASA)和噻吩并吡啶类]。
  • 其它排除标准:a)犯人或被强制性监禁(非自愿)的受试者;b)过去30天内曾使用一种研究药物或设备或既往曾随机分组到阿哌沙班临床研究中;c)被强制性监禁接受精神疾病或身体疾病(如传染病)治疗的患者

试验分组

试验药
名称 用法
中文通用名:阿哌沙班(BMS-562247)包膜片5 mg
用法用量:片剂;规格5mg;口服,一天两次,每次5mg,用药时程:连续给药直至疾病进展或发生不可接受的毒性。
中文通用名:阿哌沙班(BMS-562247) 包膜片2.5 mg
用法用量:片剂;规格2.5mg;口服,一天两次,每次2.5mg,用药时程:连续给药直至疾病进展或发生不可接受的毒性。
对照药
名称 用法
中文通用名:阿司匹林片剂81 mg
用法用量:片剂;规格81mg;每天1片、2片、3片或4片81mg的片剂(总量分别为81 mg, 162 mg, 243 mg 和 324 mg),口服,具体由研究者决定,用药时程:连续给药直至疾病进展或发生不可接受的毒性。
中文通用名:阿哌沙班(BMS-562247)包膜片的安慰剂2.5mg
用法用量:片剂;规格2.5mg;每次一片,一天2次;口服,用药时程:连续给药直至疾病进展或发生不可接受的毒性。
中文通用名:阿司匹林的安慰剂片
用法用量:片剂;规格81mg;每天1片、2片、3片或4片81mg的片剂(总量分别为81 mg, 162 mg, 243 mg 和 324 mg),口服,具体由研究者决定,用药时程:连续给药直至疾病进展或发生不可接受的毒性。
中文通用名:阿哌沙班(BMS-562247)包膜片的安慰剂5mg
用法用量:片剂;规格2.5mg;每次一片,一天2次;口服,用药时程:连续给药直至疾病进展或发生不可接受的毒性。

终点指标

主要终点指标
指标 评价时间 终点指标选择
至发生卒中或体循环栓塞复合终点的时间 本研究为事件驱动研究因而没有固定评价时间,评价从研究启动开始至有226名受试者发生了主要疗效事件时结束 有效性指标
至发生严重出血的时间 本研究为事件驱动研究因而没有固定评价时间,评价从研究启动开始至有226名受试者发生了主要疗效事件时结束 安全性指标
次要终点指标
指标 评价时间 终点指标选择
至发生卒中,体循环栓塞, 心肌梗死或血管性死亡 (重大血管性事件)的时间 本研究为事件驱动研究因而没有固定评价时间,评价从研究启动开始至有226名受试者发生了主要疗效事件时结束 有效性指标
至首次大出血或临床相关非大出血(CRNM)的时间。至双盲治疗期间的所有出血事件的时间。 本研究为事件驱动研究因而没有固定评价时间,评价从研究启动开始至有226名受试者发生了主要疗效事件时结束 安全性指标
数据安全监察委员会(DMC)
为受试者购买试验伤害保险

研究者信息

姓名 学位 职称 电话 Email 邮政地址 邮编 单位名称
朱俊 教授 010-88398866 junzhuld@hotmail.com 北京市西城区北礼士路167号中国医学科学院阜外心血管病医院 100037 中国医学科学院阜外心血管病医院

各参加机构信息

机构名称 (主要)研究者 国家 地区 城市
中国医学科学院阜外心血管病医院 朱俊 中国 北京 北京
首都医科大学附属北京朝阳医院 杨新春 中国 北京 北京
上海交通大学医学院附属瑞金医院 陆国平 中国 上海 上海
上海长海医院 李莉 中国 上海 上海
哈尔滨医科大学第一医院 梁岩 中国 黑龙江 哈尔滨
武汉大学人民医院 蒋学俊 中国 湖北 武汉
中国医科大学第一附属医院 齐国先 中国 辽宁 沈阳
大连医大第一附院 高连君 中国 辽宁 大连
北京安贞医院 吴学思 中国 北京 北京
北京世纪坛医院 周北玲 中国 北京 北京
中国人民解放军第二炮兵总医院 胡桃红 中国 北京 北京
青岛市立医院 张放 中国 山东 青岛
广东省人民医院 吴书林 中国 广东 广州
中国人民解放军白求恩国际和平医院 李俊侠 中国 吉林 长春
中日友好医院 柯元南 中国 北京 北京
四川大学华西医院 陈晓平 中国 四川 成都
苏州大学附属第一医院 宋建平 中国 江苏 苏州
中国人民解放军总医院(301医院) 杨庭树 中国 北京 北京
Hospital Privado-Centro Medico De Cordoba S.A. Amuchastegui, Luis Maria Argentina CORDOBA Cordoba
Instituto Medico De La Comunidad (Imec) Bustamante Labarta, Miguel Hugo Argentina BUENOS AIRES Junin
Sanatorio Nuestra Senora Del Rosario Bustamante, Gustavo Argentina JUJUY San Salvador De Jujuy
Clinica Coronel Suarez Caccavo, Alberto Argentina BUENOS AIRES Coronel Suarez
Clinica Regional Del Este S.R.L. Carmelo Paolasso, Horacio Cesar Argentina CORDOBA San Francisco
Hospital Italiano De La Plata Cartasegna, Luis Rodolfo Argentina BUENOS AIRES La Plata
Clinica Privada Colombo Colombo, Hugo Raul Argentina CORDOBA Cordoba
Clinica Privada Del Prado Covelli, Guillermo Argentina CORDOBA Cordoba
Framingham Centro Medico Cuadrado, Jesus Abel Argentina BUENOS AIRES La Plata
Hospital Gen. De Agudos Jose Maria Ramos Mejia Elizari, Marcelo Victor Argentina BUENOS AIRES Buenos Aires
Clinica Privada Provincial S.A. Garrido, Marcelo Alejandro Argentina BUENOS AIRES Merlo
Instituto De Investigaciones Clinicas Quilmes Hrabar, Adrian Demetrio Argentina BUENOS AIRES Quilmes
Instituto De Investigaciones Clinicas De Mar Del Plata Mackinnon, Ignacio Jorge Argentina BUENOS AIRES Mar Del Plata
Centro Medico Consultan Salud Marino, Javier Claudio Argentina BUENOS AIRES Haedo
Dim Clinica Privada Montana, Oscar Romano Argentina BUENOS AIRES Ramos Mejia
Clinica Instituto Medico Adrogue Schygiel, Pablo Omar Argentina BUENOS AIRES Adrogue
Instituto De Investigaciones Clinicas Zarate Vico, Marisa Liliana Argentina BUENOS AIRES Zarate
Instituto De Investigaciones Clinicas Bahia Blanca Vogel, Daniel Raul Argentina BUENOS AIRES Bahia Blanca
Ciprec S.A. Zaidman, Cesar Javier Argentina BUENOS AIRES Autonoma
Clinica Chutro S.R.L. Jure, Horacio Omar Argentina CORDOBA Cordoba
Instituto Del Corazon Kuschnir, Emilio Argentina CORDOBA Cordoba
Clinica Privada Caraffa Ramos, Hugo Roberto Argentina CORDOBA Cordoba
Instituto De Cardiologia De Corrientes Juana Francisca Cabra Pozzer, Domingo Luis Argentina CORRIENTES Corrientes
Hospital San Bernardo Cuneo, Carlos Alberto Argentina SALTA Salta
Centro De Investigaciones Clinicas Del Litoral S.R.L. Hominal, Miguel Angel Argentina SANTA FE Santa Fe
Instituto De Investigaciones Clinicas De Rosario Llanos, Javier Argentina SANTA FE Rosario
Sanatorio Britanico De Rosario S.A. Piskorz, Daniel Leonardo Argentina SANTA FE Santa Fe
Hospital Italiano Ramos, Jose Luis Argentina SANTA FE Rosario
Investigaciones Clinicas Tucuman Hasbani, Eduardo Gabriel Argentina TUCUMAN San Miguel De Tucuman
Instituto De Cardiologia S.R.L. Risso Patron, Facundo Argentina TUCUMAN San Miguel De Tucuman
Concord Repatriation General Hospital Brieger, David Bernard Australia New South Wales Concord
Nepean Hospital Coulshed, David Australia New South Wales Penrith
Liverpool Hospital French, John K Australia New South Wales Sydney
Renal Research Roger, Simon Australia New South Wales Gosford
Northern Sydney Central Coast Area Health Service Rogers, James Australia New South Wales Gosford
St. George Private Hospital Sader, Mark Australia New South Wales Kogarah
Coffs Harbour Health Campus Waites, Jonathon Australia New South Wales Coffs Harbour
Core Research Group Colquhoun, David Australia Queensland Milton
Wesley Research Institute Cross, David Australia Queensland Auchenflower
Princess Alexandra Hospital Garrahy, Paul Australia Queensland Woolloongabba
Gold Coast Hospital Jayasinghe, Rohan Australia Queensland Southport
Peninsula Clin Rsrch Ctr Karrasch, Jeffrey Australia Queensland Kippa Ring
Peninsula Clinical Research Center Karrasch, Jeffrey Australia Queensland Kippa Ring
Geelong Hospital Amerena, John Australia Victoria Geelong
Joondalup Cardiovascular Trials Foundation Inc. Purnell, Peter Australia Western Australia Joondalup
Medizinische Universitat Graz Fazekas, Franz Austria Graz Graz
L K H-Univ. Klinikum Graz Pieske, Burkert Austria Graz Graz
Landes-Nervenklinik Wagner-Jauregg Aichner, Franz Austria Linz Linz
Krankenhaus Der Barmherzigen Brüder Linz Eggers, Christian Claas Austria Linz Linz
Allgemeines Krankenhaus Linz Gruber, Franz Austria Linz Linz
St. Johanns Spital-Salzburger Landeskliniken Danmayr, Franz Austria Salzburg Salzburg
A.O. Krankenhaus Oberpullendorf Stockenhuber, Felix Austria Oberpullendorf Oberpullendorf
Onze-Lieve-Vrouwziekenhuis Jozef Goethals, Marc Antoon Maria Belgium Aalst Aalst
Az Klina Cools, Frank Belgium Brasschaat Brasschaat
Universitair Ziekenhuis Brussel Schoors, Danny Belgium Brussels Brussels
Az Sint-Jan Vandekerckhove, Yves Belgium Brugge Brugge
Hopital Erasme Jottrand, Maurice Belgium Bruxelles Bruxelles
Cardio Vascular Detection Centre Hollanders, Geert Belgium De Pinte De Pinte
Heilig Hart Ziekenhuis Roeselare Anne, Wim Belgium Roeselare Roeselare
Az Turnhout Campus Sint-Elizabeth J.F. Thoeng, John Khe Goan Belgium Turnhout Turnhout
Chr De Huy Marechal, Patrick Belgium Huy Huy
Hartcentrum Van Mieghem, Walter Belgium Genk Genk
Fundacao Bahiana De Cardiologia Rabelo Junior, Alvaro Brazil Bahia Salvador
Real Sociedade Portguesa Beneficencia 16/Set - Hosp Prt Teixeira, Marcelo Brazil Bahia Salvador
Sociedade Educacional Uberabense Avezum Oliveira, Livia Figueira Brazil Minas Gerais Uberaba
Hospital Mater Dei Sa Lichter, Artur Peretz Brazil Minas Gerais Belo Horizonte
Santa Casa De Misericordia De Belo Horizonte Reis, Gilmar Brazil Minas Gerais Belo Horizonte
Universidade Federal Do Triangulo Mineiro Salgado De Melo, Celso Brazil Minas Gerais Uberaba
Associacao Beneficiente Bom Samaritano D'Aurea Mora Jr., Raul Brazil Parana Maringa
Nucleo De Pesquisa Clinica S/S Ferreira Rossi, Paulo Roberto Brazil Parana Curitiba
Irmandade Da Santa Casa De Misericordia De Curitiba Moura Jorge, Jose Carlos Brazil Parana Curitiba
Hospital De Clinicas Da Universidade Federal Do Parana Pereira Da Cunha, Claudio Leinig Brazil Parana Curitiba
Sociedade Hospitalar Angelina Caron Precoma, Dalton Bertolim Brazil Parana Campina Grande De Sul
Fundacao Publica Estadual Hosp. De Clin. Gaspar Vianna Fhcgv Reis, Helder Jose Lima Brazil Para Belem
Hospital Universitario Pedro Ernesto - Uerj Albuquerque, Denilson Campos De Brazil Rio De Janeiro Rio De Janeiro
Natal Hospital Center Sa Paiva, Maria-Sanali Brazil Rio Grande Do Norte Natal
Hospital Sao Lucas Da Pucrs Abunader Kalil, Carlos Antonio Brazil Rio Grande do Sul Porto Alegre
Fundacao Universitaria De Cardiologia Dutra, Oscar Pereira Brazil Rio Grande do Sul Porto Alegre
Fundacao Universitaria De Cardiologia Glotz De Lima, Gustavo Brazil Rio Grande do Sul Porto Alegre
Irmandade Da Santa Casa De Misericordia De Porto Alegre Leaes, Paulo Ernesto Brazil Rio Grande do Sul Porto Alegre
Associacao Educadora Sao Carlos Hospital Mae De Deus Manenti, Euler R. Fernandes Brazil Rio Grande do Sul Porto Alegre
Hospital Nossa Senhora Da Conceicao Sa Pimentel Filho, Pedro Brazil Rio Grande do Sul Porto Alegre
Hospital De Clinicas De Porto Alegre Polanczyk, Carisi Anne Brazil Rio Grande do Sul Porto Alegre
Secretaria De Estado De Saude Instituto De Cardiologia Ic De Azeredo Coutinho, Mario Sergio Soares Brazil Santa Catarina Sao Jose
Sociedade Divina Providencia Hospital Santa Isabel Zimmermann, Sergio Luiz Brazil Santa Catarina Blumenau
Hospital Estadual Mario Covas De Santo Andre Aziz, Jose Luis Brazil Sao Paulo Santo Andre
Braile Clinica De Servicos E Assistencia Medica Hospitalar Braga Braile, Maria C.Valarie Brazil Sao Paulo Sao Jose Do Rio Preto
Spdm / Hospital Sao Paolo Carmargo Carvalho, Antonio Carlos De Brazil Sao Paulo Sao Paulo
Instituto Dante Pazzanese De Cardiologia De Figueredo, Oliveira B Brazil Sao Paulo Sao Paulo
Unicardio Rio Preto Ltda. Francischetti, Aloisio Brazil Sao Paulo Sao Jose Do Rio Preto
Irmandade Da Santa Casa De Misericordia De Sao Paulo Franken, Roberto Alexandre Brazil Sao Paulo Sao Paulo
Prevencor, Centro De Prevencao E Tratamento Cardiovascular Garbelini Junior, Benito Brazil Sao Paulo Marilia
Instituto Do Coracao De Marilia Guimaraes Filho, Fabio Villaca Brazil Sao Paulo Marilia
Instituto Dante Pazzanese De Cardiologia Indio Do Brasil, Clarisse Kaoru Ogawa Brazil Sao Paulo Sao Paulo
Sociedade Campineira De Educacao E Instrucao Kerr Saraiva, Jose Francisco Brazil Sao Paulo Campinas
Instituto Dante Pazzanese De Cardiologia Liporace, Idelzuita Brazil Sao Paulo Sao Paulo
Equipamentos Cardiovasculares Rio Preto Ltda Lorga Filho, Adalberto Menezes Brazil Sao Paulo San Jose- Do Rio Preto
Faculdade Regional De Medicina Sao Jose Do Rio Preto Maia, Lilia Brazil Sao Paulo San Jose- Do Rio Preto
Instituto Dante Pazzanese De Cardiologia Moreira, Dalmo Antonio R Brazil Sao Paulo Sao Paulo
Faculdade De Medicina De Marilia Pelloso, Eraldo Antonio Brazil Sao Paulo Marilia
Incor-Hospital Das Clinicas Fmusp Pereira Barretto, Antonio Carlos Brazil Sao Paulo Sao Paulo
Universidade Estadual Paulista Julio De Mesquita Filho Politi Okoshi, Marina Brazil Sao Paulo Botucatu
Instituto De Ortopedia E Traumatologia (Iot) Do Hcfmusp Sguizzatto, Guilherme Turolla Brazil Sao Paulo Sao Paulo
Spdm / Hospital Sao Paolo Vincenzo De Paola, Angelo Amato Brazil Sao Paulo Sao Paulo
Dr. Patrick T S Ma Ma, Patrick Canada Ab Calgary
Dr. Akbarally V. Lalani Lalani, Akbarally V Canada Bc New Westminster
Rivergrove Medical Clinic Saunders, Kevin K Canada Mb Winnipeg
Randy Hart, Md Hart, Randy Canada Nl St. John's
Dr. Asaad Bakbak Bakbak, Asaad I Canada On Oshawa
Jbn Medical Diagnostic Services Inc Berlingieri, Joseph C Canada On Burlington
Heart Care Research Bhargava, Rakesh Canada On Oshawa, Ontario
St. Michael'S Hospital Dorian, Paul Canada On Toronto
Hamilton Health Sciences-Hamilton General Hospital Site Eikelboom, John William Andrew Canada On Hamilton
Dr. Martin Stephen Green Green, Martin Stephen Canada On Ottawa
Hamilton Health Sciences Healey, Jeffrey Sean Canada On Hamilton
Dr. Laurie Leigh Hill Hill, Laurie Leigh Canada On Brampton
Dr. Campbell Duncan Joyner Joyner, Campbell Duncan Canada On Toronto
Andy S.C. Lam West Lincoln Memorial Hospital Lam, Andy Canada On Grimsby
Shah Nawaz, Md Nawaz, Shah Canada On Sudbury
Michael F.J. O'Mahony London Road Dia Clin & Med Centre O'Mahony, Michael F.J Canada On Sarnia
Cambridge Cardiac Care Centre Pandey, A. Shekhar Canada On Cambridge
G.S. Cardiac Lab Syan, Gurcharan Singh Canada On Sudbury
Dr. Richard H. Tytus Tytus, Richard Canada On Hamilton
Dr. Saul Vizel Cardiac Research Office Vizel, Saul Canada On Cambridge
Louis C. H. Yao, Md Yao, Louis C.H Canada On Western
Pierre Jr. Boucher, Md Boucher, Pierre Jr Canada Qc Longueuil
Medicayeb Inc. Chehayeb, Raja Canada Qc Greenfield Park
Csss Du Sud De Lanaudiere-Hopital Pierre-Le Gardeur Costi, Paolo Canada Qc Terrebonne
Chum Hotel-Dieu Coutu, Benoit Canada Qc Montreal
Neufort Inc. Fortin, Christian Canada Qc St-lambert
Centre Hospitalier Regional De Lanaudiere Kouz, Simon Canada Qc St. Charles Borromee
Claude Maranda Maranda, Claude Canada Qc Westmount
St. Jerome Medical Research Inc. Pesant, Yves Canada Qc St. Jerome
Medi Recherche Inc. Savard, Daniel Canada Qc Montreal
Bureau Dr. Richard St. Hilaire St. Hilaire, Richard Canada Qc St. Georges Beauce
Mario Talajic, Md Talajic, Mario Canada Qc Montreal
Paul Talbot Jr., Md Talbot Jr., Paul Canada Qc Quebec
Dr. S. Bose Medical Professional Corporation Bose, Sabyasachi Canada Sk Saskatoon
Hospital De Victoria Balboa Ormeno, Walter Ivan Chile ARAUCANIA Victoria
Centro De Estudios Cardiológicos Y De Medicina Interna Ltda. Lanas Zanetti, Fernando T Chile ARAUCANIA Temuco
Sociedad De Prestaciones En Salud De Los Rios Ltda. Garces, Eduardo Chile LOS RIOS Valdivia
Clinica Alemana De Osorno P-Cardenas, Sergio Hernan Chile LOS LAGOS Osorno
Cardiocob Prestaciones Medicas Cobos Segarra, Jorge Leonardo Chile METROPOLITANA Santiago
Hospital Barros Luco Trudeau Conejeros Kindel, Carlos Rafael Chile METROPOLITANA Santiago
Hospital Clinico Pontificia Universidad Catolica De Chile Corbalan Herreros, Ramon Chile METROPOLITANA Santiago
Hospital Clinico San Borja Arriaran Escobar Cerda, Edgardo Chile METROPOLITANA Santiago
Hospital Dipreca Varleta Olivares, Paola Elena Chile METROPOLITANA Santiago
Centro De Estudios Clinicos Raffo Grado, Carlos Chile VALPARAISO Vina Del Mar
Clinica Medellin Sa Botero Lopez, Rodrigo Colombia ANTIOQUIA Medellin
Fundacion Cardioinfantil - Instituto De Cardiologia Lopez Pareja, Monica Colombia Bogota Bogota
Fundacion Valle Del Lili Perafan Bautista, Pablo Colombia VALLE DEL CAUCA Cali
Fundacion Cardiovascular De Colombia Quiros Diaz, Franklin R Colombia SANTANDER Floridablanca
Fundacion Del Caribe Para La Investigacion Biomedica Triana, Miguel Alberto Colombia Barranquilla Barranquilla
Fakultni Nemocnice U Svate Anny V Brne Spac, Jiri Czech Republic Brno Brno
Nemocnice Jindrichuv Hradec, A.S. Ballek, Lubomir Czech Republic Jindrichuv Hradec Jindrichuv Hradec
Dika Centrum, S.R.O. Pederzoliova, Eva Czech Republic Havirov?mesto Havirov?mesto
Oblastni Nemocnice Kladno A.S. Stepanovova, Renata Czech Republic Kladno Kladno
Kromerizska Nemocnice A.S. Hejhal, Oldrich Czech Republic Kromeriz Kromeriz
Interni Ordinace Cisarova, Jana Czech Republic Praha Praha
Orlickoustecka Nemocnice, A.S. Dedek, Vratislav Czech Republic Usti Nad Orlici Usti Nad Orlici
Vseobecna fakultni nemocnice v Praze Gorican, Karel Czech Republic Praha 2 Praha 2
Preloucska Poliklinika A.S. Hemzsky, Libor Czech Republic Prelouc Prelouc
Mestska Nemocnice Mestec Kralove, a.s. Hudcovic, Michal Czech Republic Mestec Kralove Mestec Kralove
Med Point S.R.O. Jansky, Petr Czech Republic Praha 5 Praha 5
Poliklinika Studentsky Dum Kalousek, Igor Czech Republic Praha 6 Praha 6
Mestska Nemocnice Ostrava Kovarova, Katerina Czech Republic Ostrava Ostrava
Nemocnice Slany Marcinek, Gabriel Czech Republic Slany Slany
Oblastni Nemocnice Pribram, A.S. Polak, Martin Czech Republic Pribram Pribram
Interni A Diabetologica Ambulance Stipal, Roman Czech Republic Ostrava Ostrava
Kardiologicka Ambulance Velimsky, Tomas Czech Republic Pisek Pisek
Regionshospitalet Randers Bertelsen, Jette Denmark Randers Randers
Sydvestjysk Sygehus Esbjerg Friis, Elsebeth Vibeke Denmark Esbjerg Esbjerg
Arhus Sygehus Husted, Steen Denmark Arhus C Arhus C
Odense Universitets Hospital Pedersen, Knud Erik Denmark Odense Odense
Frederiksberg Hospital Urhammer, Soren Denmark Frederiksberg Frederiksberg
Huch Jorvi Hospital Manttari, Matti Finland Espoo Espoo
Suomen Terveystalo Melin, John Finland Jyvaskyla Jyvaskyla
Hatanpaan Sairaala, Osasto B5 Nikkila, Matti Finland Tampere Tampere
Mehilainen Oy Peuhkurinen, Keijo Finland Kuopio Kuopio
Helsinki University Central Hospital Toivonen, Lauri Finland Helsinki Helsinki
Chu De Grenoble, Hopital Nord - Albert Michallon Defaye, Pascal France Grenoble Cedex 09 Grenoble Cedex 09
Centre Hospitalier De Cholet Gacem, Karim France Cholet Cholet
Centre Hospitalier General D'Albi Galley, Daniel France Albi Cedex 9 Albi Cedex 9
Centre Hospitalier De Langres Martelet, Michel France Langres Langres
Centre Hospitalier D'Abbeville Poulard, Jean-Ernst France Abbeville Abbeville
Hopital Bichat Claude Bernard Amarenco, Pierre France Paris Paris
Hopital Bichat Claude Bernard Steg, Philippe Gabriel France Paris Paris
Hia Sainte Anne Laurent, Pierre France Toulon Armees Toulon Armees
Centre Hospitalier Intercommunal Des Alpes Du Sud Olive, Thierry France Sisteron Sisteron
Kreiskrankenhaus Altenburg Berrouschot, J?rg Germany Altenburg Altenburg
Charite Campus Virchow Klinikum Haverkamp, Wilhelm Germany Berlin Berlin
Vivantes Wenckebach-Kliniken Henzgen, Rudolf Germany Berlin Berlin
Helios Klinikum Berlin-Buch Monti, Jan Germany Bonn Bonn
St. Marien Hospital Omran, Heyder Germany Berlin Berlin
Vivantes Auguste-Viktoria Klinikum Schuhlen, Helmut Germany Berlin Berlin
Praxis Fur Kardiologische Diagnostik Schulze, Uwe Germany Berlin Berlin
Universitaetsmedizin Berlin - Charité-Campus Mitte Stangl, Verena Germany Berlin Berlin
Klinikum Der Johann Wolfgang Goethe-Universitat Hohnloser, Stefan Germany Frankfurt am Main Frankfurt am Main
Institut Für Klinische Forschung Sehnert, Walter Germany Dortmund Dortmund
Universit?tsklinikum Essen Weimar, Christian Germany Essen Essen
Universit?tsklinik Und Poliklinik Für Innere Medizin Iii Ebelt, Henning Germany Halle/saale Halle/saale
Asklepios Klinik Barmbek Groenefeld, Gerian Germany Hamburg Hamburg
Universitares Herz- Und Gafasszentrum Mathey, Detlef Germany Hamburg Hamburg
Praxis Dr. Sperling Sperling, Karsten Germany Hamburg Hamburg
Ambulantes Herzzentrum Kassel Appel, Karl-Friedrich Germany Kassel Kassel
Kliniken Der Stadt Koln Ggmgh Dormann, Arno Germany Koln Koln
Medizinische Universitatsklinik Heidelberg (Krehl-Klinik) Licka, Manuela Germany Heidelberg Heidelberg
Heidelberger Praxisklinik Fur Kardiologie Natour, Mohammed Germany Heidelberg Heidelberg
Asklepios Kliniken Langen Olbrich, Hans-Georg Germany Langen Langen
Gemeinschaftspraxis Dres. Lobe, Weissbrodt, Boran Weissbrodt, Matthias Germany Leipzig Leipzig
Kardiologische Praxis Mainz Drexler, Michael Germany Mainz Mainz
Universitaetsklinikum Mannheim Harenberg, Job Germany MANNHEIM MANNHEIM
Klinikum Mannheim- Universitatsklinikum Hoffmann, Ursula Germany MANNHEIM MANNHEIM
Klinikum Der Johannes Gutenberg Universitaet Mainz Munzel, Thomas Germany Mainz Mainz
Marienkrankenhaus Papenburg Gmbh Pollock, Berthold Germany Papenburg Papenburg
Kardiologische Gemeinschaftpraxis Riesa Ebert, Hans-Holger Germany Riesa Riesa
Marienkrankenhaus Ggmbh Flesch, Markus Germany Soest Soest
Evangelisches Krankenhaus Witten Horacek, Thomas Germany Witten Witten
Forschungszentrum Ruhr Kahrmann, Gerd Germany Witten Witten
Universitat Regensburg, Berzirksklinikum Regensburg Rochus Schlachetzki, Felix J Germany Regensburg Regensburg
Institut Fuer Klinische Forschung Schumacher, Michael Germany Wolmirstedt Wolmirstedt
General Hospital Of Athens-Hippocratio Kallikazaros, Ioannis Greece Athens Athens
General Hospital Of Larissa Karamitsos, Konstantinos Greece Larisa Larisa
Diagnostic And Therapeutic Center Of Athens-Hygeia Karatzas, Nicholas Greece Athens Athens
General Hospital Of Thiva Skoumpourdis, Emmanouil Greece Thiva Thiva
Pamela Youde Nethersole Eastern Hospital Li, Shu Kin China HONGKONG HONGKONG
Prince Of Wales Hospital Sing Wong, Lawrence Ka China HONGKONG HONGKONG
Queen Mary Hospital Tse, Hung Fat China HONGKONG HONGKONG
Mgm Medical College & My Hospital Bharani, Anil India Indore Indore
St. John'S Medical College Hospital Iyengar, Shamanna India Bangalore, Karnataka Bangalore, Karnataka
Caritas Hospital Joseph, Johny India Kottayam Kottayam
Cresent Hospital And Heart Centre Khan, Aziz India Dhantoli Dhantoli
Care Institute Of Medical Sciences Naik, Ajay M India Ahmedabad Ahmedabad
S.P. Medical College And A.G. Hospitals Panwar, Raja Babu India Bikaner Bikaner
Medwin Hospitals Ramesh Babu, Byrapaneni India Andhra Pradesh Hyderabad
Bhagawan Mahaveer Jain Heart Centre Ramesh, Srinivasaiah India Karnataka Bangalore
Vikram Hospital & Heart Care Srinivas, Arun India Mysore Mysore
Shree Sai Baba Heart Hospital And Research Center Dharmadhikari, Aniruddha India Maharashtra Nashik
Gautams Clinic Gautam, Nilesh India Maharashtra Mumbai
Poona Hospital And Research Centre Hiremath, Jagdish India Maharashtra Pune
Avanti Institute Of Cardiology Pvt. Ltd Jain, Archana Santosh India Maharashtra Nagpur
Pulse Diagnostix Cardiac & Medical Centre Srikanthan, Vinjamur India Maharashtra Pune
Bhatia Hospital Thacker, Hemant India Maharashtra Mumbai
S R Kalla Memorial Gastro & General Hospital Gupta, Jugal Bihari India Rajasthan Jaipur
M V Hospital And Research Centre Gupta, Sandeep Kumar India Uttar Pradesh Lucknow
Apollo Hospitals Oomman, Abraham India Tamil Nadu Chennai
Dr Soetomo General Hospital Baktijasa Dharmadjati, Budi Indonesia Surabaya Surabaya
Syaiful Anwar Hospital Hendrawan, Dadang Indonesia Malang Malang
Sanglah Hospital Nadha, Ketut Badjra Indonesia Denpasar Denpasar
Dr M. Djamil Hospital Syafri, Masrul Indonesia Padang Padang
Dr M. Hoesin Hospital Syawal, Aulia Indonesia Palembang Palembang
Rsup. Dr. Hasan Sadikin Yahya, Achmad Fauzi Indonesia Bandung Bandung
Binawaluya Hospital Munawar, Muhammad Indonesia Jakarta Timur Jakarta Timur
Sardjito General Hospital Setianto, Budi Yuli Indonesia Yogyakarta Yogyakarta
Premier Jatinegara Hospital Tedjasukmana, Pradana Indonesia Jakarta Jakarta
Cipto Mangunkusumo Hospital Yamin, Muhammad Indonesia Jakarta Jakarta
Rambam Medical Center Brenner, Benjamin Israel Haifa Haifa
Barzilai Hospital Katz, Amos Israel Ashkelon Ashkelon
Gefen Cardiac Health Center Klainman, Eliezer Israel Givatayim Givatayim
Lady Davis Carmel Medical Center Lewis, Basil Israel Haifa Haifa
Hillel Yaffe Medical Center Shocht, Michael Israel Hadera Hadera
Ha'Emek Medical Center Turgeman, Yoav Israel Afula Afula
Holy Family Hospital Francis, Adi Israel Nazareth Nazareth
Rabin Mc Lahav, Meir Israel Petach-tikva Petach-tikva
Sieff Medical Center Marmor, Alon Israel Safed Safed
Nazareth Hospital Emms Omary, Muhamad Israel Nazareth Nazareth
Tel Aviv Sourasky Medical Center Viskin, Samuel Israel Tel Aviv Tel Aviv
The Edith Wolfson Medical Center Zimlichman, Reuven Israel Holon Holon
Azienda Ospedaliera Universitaria S. Martino Balbi, Manrico Italy Genova Genova
Ospedale Casolo, Giancarlo Italy Lido Di Camaiore Lido Di Camaiore
Univ. Studi De Caterina, Raffaele Italy Chieti Chieti
Ospedale Mazzoni Moretti, Luciano Italy Ascoli Piceno Ascoli Piceno
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Novo, Salvatore Italy Palermo Palermo
Ospedale F. Veneziale Centro Per L'Ipertensione Arteriosa Olivieri, Carlo Italy Isernia Isernia
Universita E Azienda Ospedaliera Di Perugia Bentivoglio, Maurizio Italy Perugia Perugia
Azienda Ospedaliero Universitaria Glorioso, Nicola Italy Sassari Sassari
Ospedale Unico Di Rete Sant'Antonio Mos, Lucio Italy San Daniele Del Fruli San Daniele Del Fruli
Presido Ospedaliero Di Sassari- Ospedale Ss Annunziata Terrosu, Pierfranco Italy Sassari Sassari
Kon Yang University Hospital Bae, Jangho Republic of korea Daejeon Daejeon
Kosin University Gospel Hospital Cha, Tae-Joon Republic of korea Busan Busan
Kyungpook National University Hospital Chae, Shung Chull Republic of korea Daegu Daegu
Dongguk University International Hospital Lee, Myoung Mook Republic of korea GYEONGGI-DO Goyang-si
Chonnam National University Hospital Cho, Jeong Gwan Republic of korea Gwangju Gwangju
Seoul National University Bundang Hospital Kim, Cheol Ho Republic of korea Seongnam-si Seongnam-si
Hanyang University, Kuri Hospital Kim, Soon Kil Republic of korea KYUNGGI-DO Kuri-city
Konkuk University Hospital Kim, Hyun-Joong Republic of korea Seoul Seoul
The Catholic University Of Korea St. Paul'S Hospital Kim, Jae Hyung Republic of korea Seoul Seoul
Seoul National University Hospital Oh, Seil Republic of korea Seoul Seoul
University Malaya Medical Centre Chee, Kok Han Malaysia KUALA LUMPUR Kuala Lumpur
Hospital Sultanah Aminah Lee, Chuey Yan Malaysia JOHOR Johor Bahru
Universiti Kebangsaan Malaysia Medical Centre Maskon, Oteh Malaysia KUALA LUMPUR Cheras
Hospital Kuala Lumpur Sinnadurai, Jeyaindran Malaysia KUALA LUMPUR Kuala Lumpur
Hospital Pulau Pinang Ismail, Omar Malaysia PENANG Pulau Pinang
Sarawak General Hospital Kui-Hian, Sim Malaysia SARAWAK Kuching
Unidad De Investigacion En Salud De Chihuahua Sc Acosta Grajeda, Jesus Manuel Mexico Chihuahua Chihuahua
Fundacion Cardiovascular De Aguascalientes A.C. Bayram Llamas, Edmundo Mexico Aguascalientes Aguascalientes
Hospital Angeles Del Pedregal Escarcega, Joseluis Mexico Distrito Federal Mexico City
Hospital General De Mexico Fernandez, Luis Mexico Distrito Federal Mexico City
Instituto Nacional De Cardiologia Dr. Ignacio Chavez Gonzalez-Hermosillo, J. Antonio Mexico Distrito Federal Mexico
Instituto Biomedico De Investigacion A.C Ramirez Isunza, Jose Manuel Mexico Aguascalientes Aguascalientes
Cardioprevent Clinica De Prevencion Cardiovascul. Y Diabetes Alvarado Ruiz, Ricardo Mexico Durango Durango
Hosp. Gen. De Atizapan Dr. S. G. Herrejon, Daimler-Chrysler Calderon Marquez, Maria Antonieta J Mexico Estado De Mexico Atizapan De Zaragoza
Hospital General De Acapulco Matadamas, Norberto Mexico Guerrero Acapulco
Clinica De Estudios Medicos S.C. Olvera, Rafael Mexico Jalisco Guadalajara
Francisco Javier Robles Torres, Md - Private Practice Robles Torres, Francisco Javier Mexico Jalisco Guadalajara
Hospital Dr. Angel Leano Velasco Sanchez, Raul Gerardo Mexico Jalisco Zapopan
Instituto De Corazon De Queretaro Alcocer, Marco Mexico Queretaro Queretaro
Hospital Angeles Centro Medico Del Potosi Arenas Leon, Jose Luis Mexico San Luis Potosi San Luis Potosi
Hospital Central Leiva Pons, Jose Luis Mexico San Luis Potosi San Luis Potosi
Unidad Medica De Tratamientos Avanzados, Sc Lopez Villezca, David Mexico Nuevo Leon Monterrey
Cardioarritmias E Investigacion S.C. Rodriguez Briones, Ignacio Mexico San Luis Potosi San Luis Potosi
Hospital Angeles Culiacan De Los Rios Ibarra, Manuel Odin Mexico Sinaloa Culiacan
Centro De Espec. Medicas Del Est. De Veracruz 'Dr. R. Lucio' Lopez Rosas, Enrique Mexico Veracruz Xalapa
Hospital Centro Medico Ruiz Gastelum, Edith Dalila Mexico Sonora Hermosillo
Oslo Universitetssykehus Hf Ulleval Berge, Eivind Norway Oslo Oslo
Dr. Erik Buchmann Buchmann, Erik Norway Oslo Oslo
Kristiansund Sykehus, Helse Nordm?re Og Romsdal Dimmen, Arild Norway Kristiansund Kristiansund
Vestre Viken Hf, Kongsberg Sykehus Meen, Oystein Norway Kongsberg Kongsberg
Hospitalet Betanien Nakling, Arne E Norway Fyllingsdal Fyllingsdal
Perpetual Help University Brillantes, Amelita Philippines Binan Binan
Philippine General Hospital Dans, Antonio Miguel Philippines Manila Manila
Cagayan De Oro Medical Center Edmilao, Manuel Ignatius Philippines MISAMIS ORIENTAL Cagayan De Oro City
Private Clinic Of Dr. Ellen Morales-Palomares Morales-Palomares, Ellen Philippines ILOCOS NORTE Laoag City
De La Salle University Medical Center Rey, Nannette Philippines Cavite Cavite
University Of Perpetual Help Dalta Medical Center Sevilla, Maria Rosario Philippines Las Pinas City Las Pinas City
Mindanao Sanitarium And Hospital Timonera, Miriam Philippines LANAO DEL NORTE Iligan City
Dr. Pablo O. Torre Memorial Hospital Villacin, Luciene Philippines NEGROS OCCIDENTAL Bacolod City
Niepubliczny Zaklad Opieki Zdrowotnej Esculap Derezinski, Tadeusz Poland Gniewkowo Gniewkowo
Spzoz Miejski Szpital Zespolony Janik, Krzysztof Poland Czestochowa Czestochowa
Nzoz Vito-Med Sp. Z O.O. Krauze-Wielicka, Magdalena Poland Gliwice Gliwice
Nzoz Pro Cordis Sopockie Miekus, Pawel Poland Gdynia Gdynia
Wojewodzki Szpital Zespolony W Elblagu Reszka, Zygfryd Poland Elblag Elblag
Spzoz Szpital Zachodni Im. Jana Pawla Ii Stopinski, Marek Poland Grodzisk Mazowiecki Grodzisk Mazowiecki
Publiczny Specjalistyczny Zaklad Opieki Zdrowotnej Bronisz, Marek Aleksander Poland Inowroclaw Inowroclaw
Spzoz Lubartow Gieroba, Andrzej Poland Lubartow Lubartow
Swietokrzyskie Centrum Kardiologii Janion, Marianna Poland Kielce Kielce
Przychodnia Lekarsko-Stomatologiczna Dentmal Malinowski, Stanislaw Poland Nowy Sacz Nowy Sacz
Prywatny Gabinet Lekarski Michal Ogorek Ogorek, Michal Poland Piotrkow Trybunalski Piotrkow Trybunalski
Nzoz Peruga, Jan Poland Lodz Lodz
Nzoz Solumed Boruczkowska-Kaszkowiak, Anna Poland Poznan Poznan
Wielospecjalistyczny Niepubliczny Zaklad Opieki Zdrowotnej Kincel, Krzysztof Poland Siemianowice Slaskie Siemianowice Slaskie
Specjalistyczna Przychodnia Lekarska Korzeniak, Romuald Poland Plock Plock
Sp Zoz Pulawy Monies, Franciszek Poland Pulawy Pulawy
Spzoz Szpital Wegrow, Oddzial Internistyczno-Kardiologiczny Czerski, Tomasz Poland Wegrow Wegrow
Specjalistyczny Gabinet Lekarski Derlaga, Boguslaw Poland Tarnow Tarnow
Nzoz Przychodnia Kania, Grzegorz Poland Skierniewice Skierniewice
Wojewodzki Szpital Zespolony Kawka-Urbanek, Teresa Poland Skierniewice Skierniewice
Nzoz Starowka Zarebinski, Maciej Poland Warsaw Warsaw
Spzoz Szpital Grochowski Im Dr R. Masztaka Budaj, Andrzej Poland Warszawa Warszawa
Wojewodzki Szpital Brodnowski, Sp Zoz Dluzniewski, Miroslaw Poland Warszawa Warszawa
Slaskie Centrum Chorob Serca Kalarus, Zbigniew Poland Zabrze Zabrze
Szpitala Uniwersyteckiego W Krakowie Kawecka-Jaszcz, Kalina Poland Krakow Krakow
Amicor Centrum Kardiologiczne Piotrowski, Wieslaw Poland Krakow Krakow
Gabinet Lekarski Dr. Med. Ryszard Serafin-Kardiolog Serafin, Ryszard Poland Zarow Zarow
Regional St. Healthcare Inst. Altai Reg. Cardiol. Dispensary Duda, Alexey Russian Federation Barnaul Barnaul
Medical Association, Novaya Bolnitsa Fokina, Elena Russian Federation Ekaterinburg Ekaterinburg
Ural Institute Of Cardiology Freydlin, Marina Russian Federation Ekaterinburg Ekaterinburg
City Clinical Hospital #3 Levin, Alexander Russian Federation Chelyabinsk Chelyabinsk
Kaluga Regional Hospital Pasechnik, Elena Russian Federation Kaluga Kaluga
Municipal Inst Healthcare Barbarash, Olga Russian Federation Kemerovo Kemerovo
Kazan State Medical Univ. Kamalov, Gadel Russian Federation Kazan Kazan
Kuban St Med Univ,Dept Hosp Therapy Based Emer Med Care Hosp Kanorsky, Sergey Russian Federation Krasnodar Krasnodar
State Education Institution Of Higher Professional Education Shvarts, Yury Russian Federation Kazan Kazan
Municipal Medical And Prophylactic Instit. City Hospital #28 Suvorov, Alexander Russian Federation Nizhniy Novgorod Nizhniy Novgorod
Muz Budget Novosibirsk City Clinical Hospital #1 Barbarich, Vladimir Russian Federation Novosibirsk Novosibirsk
Sei Kpe Perm State Medical Academy Of Roszdrav Koziolova, Natalya Russian Federation Perm Perm
Municipal Health Care Institution/City Clinical Hospital #4 Lapin, Oleg Russian Federation Perm Perm
Novosibirsk Regional Clinical Cardiological Dispensary Yakhontova, Polina Russian Federation Novosibirsk Novosibirsk
State Inst. For Healthcare, Leningrad Regional Clinic. Hosp. Butynskaya, Emilia Russian Federation Saint-petersburg Saint-petersburg
Saint Petersburg State Institution of Healthcare War Veterans Hospital Konstantinov, Vladimir Russian Federation Saint-petersburg Saint-petersburg
Spb National Healthcare Instit. City Outpatient Clinic No 34 Nosova, Nina Russian Federation Saint-petersburg Saint-petersburg
Medem International Clinic And Hospital Obrezan, Andrey Russian Federation Saint-petersburg Saint-petersburg
Saint-Petersburg Krasnogvardeysky Dist Med Sports Dispensary Sherenkov, Alexander O Russian Federation Saint-petersburg Saint-petersburg
Federal Center Of Heart, Blood, Endocrinology Tatarsky, Boris Russian Federation Saint-petersburg Saint-petersburg
Fed Ctr Of Heart,Blood & Endocrinology Named Aft V.A.Almazov Treshkur, Tatiana Russian Federation Saint-petersburg Saint-petersburg
Saint-Petersburg Municipal Hospital #28 Zalevsky, Grigory Russian Federation Saint-petersburg Saint-petersburg
Clinical City Hospital #46 Zotov, Dmitriy Russian Federation Saint-petersburg Saint-petersburg
Federal St Budget Inst. Out-Patient Clinic #5 Of Russian Fed Aleksandrova, Elena Russian Federation Moscow Moscow
Municipal Clinical Hospital #23 Named After Medsantrud Arkhipov, Vladimir Russian Federation Moscow Moscow
Russian St Med Univ, Dept Of Outpat. Therapy Diag Clin Ctr 1 Bart, Boris Russian Federation Moscow Moscow
Russian State Medical University Belousov, Yuri Russian Federation Moscow Moscow
State Research Center For Preventive Medicine Bochkareva, Elena Russian Federation Moscow Moscow
Federal State Healthcare Inst Clin Hosp123 Of Fmba Of Russia Chernichka, Irina Russian Federation Moscow Moscow
Russian Fed Def. Ministry Burdenko Main Military Clin. Hosp. Chernov, Sergey Russian Federation Moscow Moscow
Fed St Inst Rus Card Res&Prod Ctr, Min Of Hlth&Sd Of Rus Fed Golitsyn, Sergey Russian Federation Moscow Moscow
Fgu Cent. Clin Hosp Of Civ Aviat Of Min Of Transp Of Rus Fed Gorbachenkov, Anatoly Russian Federation Moscow Moscow
O.M. Filatov City Clinical Hospital #15 Gordeev, Ivan Russian Federation Moscow Moscow
City Clinical Hospital Named After S.P. Botkin Libov, Igor Russian Federation Moscow Moscow
Moscow State Univ. Of Medicine And Dentistry Clin Hosp #40 Martynov, Anatoly Russian Federation Moscow Moscow
Veterans Hospital No. 3, Cardiology Department Mkrtchian, Vagan Russian Federation Moscow Moscow
Fed St Inst Rus Card Res&Prod Ctr, Min Of Hlth&Sd Of Rus Fed Panchenko, Elizaveta Russian Federation Moscow Moscow
Russian State Medical University Poteshkina, Nataliya Russian Federation Moscow Moscow
Fgu Central Clinical Hospital With Polyclinic Of President Vaniev, Sergey Russian Federation Moscow Moscow
State Institution Of Healthcare Samara Reg Cardio Dispensary Duplyakov, Dmitry Russian Federation Samara Samara
Yaroslavl Regional Clinical Hospital Khrustalev, Oleg Russian Federation Yaroslavl Yaroslavl
Samara Regional Clinical Hospital Named After M.I. Kalinin Lebedev, Petr Russian Federation Samara Samara
Tver Regional Clinical Hospital Mazur, Evgeniy Russian Federation Tver Tver
Research Institute Of Cardiology Popov, Sergey Russian Federation Tomsk Tomsk
Saratov Scientific Research Institute Of Cardiology Reshetko, Olga Russian Federation Saratov Saratov
State Autonomy Institute of Health of Tyumen Region Shalaev, Sergey Russian Federation Tumen Tumen
State Healthcare Inst., Ryazan Reg. Cardiological Dispensary Yakushin, Sergey Russian Federation Ryazan Ryazan
Tan Tock Seng Hospital Foo, David Singapore Singapore Singapore
Khoo Teck Puat Hospital Ong, Hean Yee Singapore Singapore Singapore
National Heart Centre Of Singapore Tan, Ru San Singapore Singapore Singapore
Changi General Hospital Tong, Khim Leng Singapore Singapore Singapore
Rosepark Hospital Bester, Frederik South Africa FREE STATE Bloemfontein
Netcare Private Hospital Theron, Hennie Du Toit South Africa FREE STATE Bloemfontein
Wilgers Medical Consortium Snyders, F. A South Africa GAUTENG Pretoria
Emmed Research Cc Van Nieuwenhuizen, Elane South Africa GAUTENG Pretoria
Union Hospital Venter, Tjaart Petrus South Africa GAUTENG Alberton
Groote Schuur Hospital Commerford, Patrick Joseph South Africa WESTERN CAPE Cape Town
Vergelegen Medi Clinic Engelbrecht, Johannes Mattheus South Africa WESTERN CAPE Somerset West
Tiervlei Trial Center Pretorius, Maria M South Africa WESTERN CAPE Bellville, Cape Town
Clinical Projects Research Sa (Pty) Ltd Van Zyl, Louis J South Africa WESTERN CAPE Worcester
Hospital Universitario Nuestra Senora Del Perpetuo Socorro Abizanda Soler, Pedro Spain Albacete Albacete
Hospital Universitario San Cecilio Correa, Concepcion Spain Granada Granada
Consorcio Hospital Provincial De Castellon Facila, Lorenzo Spain Castellon De La Plana Castellon De La Plana
Hospital Universitario De Bellvitge Sabate, Xavier Spain Barcelona Barcelona
Hospital Universitario Ramon Y Cajal Cruz Jentoft, Alfonso J Spain Madrid Madrid
Hospital Lucus Augusti Monte Secades, Rafael Spain Lugo Lugo
Hospital De Calde Veiga Fernandez, Fernando Spain Lugo Lugo
Hospital General Universitario Gregorio Maranon Vidan, Maria Teresa Spain Madrid Madrid
Hospital Universitario Ramon Y Cajal Yebra, Miguel Spain Madrid Madrid
Hospital Torrevieja Salud Mirete Ferrer, Jose Carlos Spain Torrevieja Torrevieja
Hospital Universitario Dr. Peset Orriach, Maria Dolores Spain Valencia Valencia
Akademiska Sjukhuset Blomstrom Lundqvist, Carina Sweden Uppsala Uppsala
Sahlgrenska University Hospital/Ostra Jacobsson, Filip Sweden Gothenburg Gothenburg
Sahlgrenska Universitetssjukhuset/Molndal Klintberg, Lars Sweden Molndal Molndal
Forskningsenheten Lundby Sjukhus Ulvenstam, Goran Sweden Goteborg Goteborg
City Heart Hoglund, Christer Sweden Stockholm Stockholm
Capio S:T G?rans Sjukhus Ab Maru, Fikru Sweden Stockholm Stockholm
Karolinska University Hospital, Huddinge Rasmanis, Gundars Sweden Stockholm Stockholm
Sodersjukhuset Rosenqvist, Marten Sweden Stockholm Stockholm
Far Eastern Memorial Hospital Chu, Shu-Hsun China Taiwan Taipei
Kaohsiung Medical University Chung-Ho Memorial Hospital Lai, Wen-Ter China Taiwan Kaohsiung
National Cheng Kung University Hospital Lin, Li-Jen China Taiwan Tainan
Shin Kong Wu Ho-Su Memorial Hospital Shyu, Kou-Gi China Taiwan Taipei
Chung-Shan Medical University Hospital Ueng, Kwo Chang China Taiwan Taichung
Chang Gung Memorial Hospital-Linkou Wang, Chun-Chieh China Taiwan Taoyuan
Istanbul University Medical Faculty Adalet, Kamil Turkey Istanbul Istanbul
Kirikkale University Medical Faculty Ebinc, Haksun Turkey Kirikkale Kirikkale
Suleyman Demirel University Medical Faculty Ozaydin, Mehmet Turkey Isparta Isparta
Istanbul University Cardiology Institute Turkoglu, Cengizhan Turkey Istanbul Istanbul
Central City Clinical Hospital #1, Cardiology Department Bagriy, Andriy Ukraine Donetsk Donetsk
Dnipropetrovsk State Medical Academy, Hospital Therapy #1 Kuryata, Olexandr Ukraine Dnipropetrovsk Dnipropetrovsk
Kharkiv Med. Acad. Of Postgrad Educ, Bereznyakov, Igor Ukraine Kharkiv Kharkiv
Mechnikov Inst. Of Microbiology & Immunology Of Ams-Ukraine Grishyna, Olena Ukraine Kharkiv Kharkiv
Central Clinical Hospital Of Ukrzaliznitsia, Kraiz, Igor Ukraine Kharkiv Kharkiv
City Clinical Hospital #27, Prokhorov, Oleksandr Ukraine Kharkiv Kharkiv
Kharkiv Medical Academy Of Postgrad Ed Kzoz City Clin Hosp 8 Tseluyko, Vira Ukraine Kharkiv Kharkiv
National Medical University Amosova, Kateryna Ukraine Kyiv Kyiv
Municipal Clinical Hospital #1 Karpenko, Oleksandr Ukraine Kyiv Kyiv
National Med Acad Of Postgrad Ed P.L.Shupik Region Clin Hosp Khimion, Lyudmila Ukraine Kyiv Kyiv
National Scientific Ctr-The M.D. Strazhesko Inst. Of Cardio. Parkhomenko, Alexander Ukraine Kyiv Kyiv
Kyiv Emergency Care Hospital Rudenko, Leonid Ukraine Kyiv Kyiv
State Institution, Institute Of Gerontology Ams Of Ukraine Stadnjuk, Leonid Ukraine Kyiv Kyiv
Ninewells Hospital And Medical School Macwalter, Ronald United Kingdom Angus/forfarshire Dundee
Antrim Area Hospital Trouton, Thomas G United Kingdom Antrim Antrim
Aberdeen Royal Infirmary Webster, John United Kingdom Aberdeenshire Aberdeen
Basildon Hospital Aggarwal, Rajesh United Kingdom Essex Basildon
Chesterfield Royal Hospital Nhs Foundation Trust Cooke, Justin United Kingdom Derbyshire Chesterfield
Queen'S Hospital Kadr, Honer United Kingdom Essex Romford
Craigavon Area Hospital Moriarty, Andrew, J United Kingdom Armagh Craigavon
Colchester General Hospital Tang, Kare United Kingdom Essex Colchester
Victoria Hospital Francis, Charles Mark United Kingdom Fife Kirkcaldy
Western Infirmary, Gardiner Institute Muir, Scott United Kingdom Lanarkshire Glasgow
St George'S University Of London Savelieva, Irina United Kingdom Greater London London
Blackpool Victoria Hospital Brack, Michael United Kingdom Lancashire Blackpool
Northwick Park Hospital Senior, Roxy United Kingdom Middlesex Harrow
Barnsley District Hospital Albazzaz, Mohammad United Kingdom South Yorkshire Barnsley
Bassetlaw District General Hospital Alwail, Ali Nagi N United Kingdom Nottinghamshire Worksop
Northampton General Hospital Davey, Patrick United Kingdom Nottinghamshire Northampton
Royal Alexandra Hospital Findlay, Iain United Kingdom Renfrewshire Paisley
Forth Valley Royal Hospital Glen, Stephen United Kingdom Stirlingshire Larbert
City Hospital Lip, Gregory Y.H United Kingdom West Midlands Birmingham
University Of Newcastle Thomas, Simon United Kingdom Tyne And Wear Newcastle Upon Tyne
St Richards Hospital Wong, Yuk-Ki United Kingdom West Sussex Chichester
Southern General Hospital Murdoch, David United Kingdom Lanarkshire Glasgow
Mobile Heart Specialists, Pc Bedwell, Noel Wheeler USA AL Mobile
Cardiology Consultants Of Orange County Med. Group Inc Gogia, Harinder S USA CA Anaheim
Santa Rosa Cardiology Hunter, John J USA CA Santa Rosa
Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group Jardula, Michael F USA CA Palm Springs
North County Internal Medicine Lafata, John USA CA Vista
Kaiser Permanente Medical Center, West Los Angeles Lang, Daniel USA CA Los Angeles
San Diego Managed Care Group Maletz, Louis USA CA San Diego
Yogesh K. Paliwal Md Paliwal, Yogesh Kumar USA CA Pomona
Southwest Heart Peart, Brenda C USA AZ Tucscon
University Of California, San Diego Raisinghani, Ajit USA CA San Diego
Cardiology Associates Of New Haven,Pc Gerber, Jaime R USA CT Guilford
Stamford Therapeutics Consortium Heiman, Mark D USA CT Stamford
Washington Va Medical Center Moore, Hans J USA DC Washington
Research Alliance, Inc. Amin, Mahesh USA FL Clearwater
The Heart & Vascular Institute Of Florida Black, Robert A USA FL Dunedin
The Heart Group Of Lee Memorial Health System Burton, M. Erick USA FL Fort Myers
Cardiovascular Center Of Sarasota El Shahawy, Mahfouz USA FL Sarasota
Baptist Heart Specialists Hilton, Thomas C USA FL Jacksonville Beach
Kim A. Klancke, Md Klanke, Kim A USA FL Daytona Beach
Michael F. Lesser, Md, Facc Osler Medical Inc. Lesser, Michael USA FL Melbourne
St. Vincent'S Ambulatory Care, Inc Magnano, Anthony USA FL Jacksonville
Broward General Medical Center Perloff, David USA FL Fort Lauderdale
Integrated Care Llc D/B/A Cardiovascular Consultants Of S Fl Schneider, Ricky USA FL Tamarac
Bay Pines Va Healthcare System Swamy, Mallikarjuna USA FL Bay Pines
The Heart & Vascular Institute Of Florida Walsh, Ronald Lennox USA FL Dunedin
North Chicago Va Medical Center Arora, Rohit Romesh USA IL North Chicago
Southeast Regional Research Group Elkin, Gary USA GA Savannah
Fox Valley Clinical Research Center, Llc Gill, Santosh K USA IL Aurora
Northeast Georgia Heart Center, Pc Ramaswamy, Karthik USA GA Gainesville
Atlanta Institute For Medical Research, Inc Rosenthal, Steven Michael USA GA Atlanta
Southeast Regional Research Group Surber, Joseph G USA GA Augusta
Hutchinson Clinic, Pa Brachfeld, Claude USA KS Hutchinson
Dr. Jeffrey Chen Chen, Yi-Cheng USA LA Lafayette
St Francis Medical Group - Indiana Heart Physicians Genovely, Harry C USA IN Indianapolis
St. Vincent Medical Group, Inc. Parr, Kirk L USA IN Indianapolis
Pentucket Medical Associates Bilazerian, Seth USA MA Haverhill
Michigan Heart And Vascular Specialists Levanovich, Peter E USA MI Petoskey
Academic Cardiology Associates Mcgough, Martin F USA MI Rochester Hills
Peninsula Cardiology Associates, P.A. Nsah, Emmanuel Nchinda USA MD Salisbury
Great Lakes Heart Center Of Alpena Salacata, Abraham USA MI Alpena
Henry Ford Hospital K-15 Shah, Vinay USA MI Detroit
Glacier View Cardiology, Pc Gillespie, Eve L USA MT Kalispell
Tupelo Neurology Clinic, Pa Graff, Justin C USA MS Tupelo
Kansas City Cardiology Associates, Inc. Lee, John Kenneth N USA MO Kansas City
Missouri Cardiovascular Specialists Ravipudi, Sanjeev USA MO Columbia
University Of Missouri Weachter, Jr., Richard USA MO Columbia
Terry V. Arnold, Md Arnold, Terry V USA NC Lexington
Sanford Cardiology Atieh, Mahmoud USA NC Sanford
Capital Cardiology Associates Benton, Robert USA NY Troy
NYU Hudson Valley Cardiology Hamroff, Glenn S USA NY Cortlandt Manor
Dr William Kufs Kufs, William USA NY Saratoga Springs
Hunterdon Cardiovascular Associates Kutscher, Jr., Austin Harrison USA NJ Flemington
Capital Cardiology Associates Shah, Parag USA NY Albany
Pinehurst Medical Clinic, Inc Simpson, Patrick USA NC Pinehurst
Long Island Heart Associates Smith, Richard H USA NY Mineola
Integris Cardiovascular Physicians Anderson, Jerome Lyman USA OK Oklahoma City
Davis Heart & Lung Research Institute Baliga, Ragavendra USA OH Columbus
Ira R. Friedlander, M.D. Friedlander, Ira Ray USA OH Canton
The Portland Clinic, Llp Naito, Ronald W USA OR Portland
Hillsboro Cardiology Pc Promisloff, Steven D USA OR Hillsboro
Oregon Medical Group - Clinical Research Saxman, Karl A USA OR Eugene
South Oklahoma Heart Research Tahirkheli, Naeem K USA OK Oklahoma City
Comprehensive Cardiology Consultants Fields, Ronald H USA PA Langhorne
Lowcountry Medical Group, Llc Floyd, John USA SC Beaufort
Cardiology Consultants Of Philadelphia Grena, Paul Gregory USA PA Yardley
Internal Medicine Of Greer Henry, Iii, W. John USA SC Greer
Grand View - Lehigh Valley Health Services Hermany, Paul USA PA Sellersville
West Chester Cardiology Jan, Mian A USA PA West Chester
Medical University Of South Carolina Zwerner, Peter USA SC Charleston
Knoxville Heart Group Ayres, Thomas M USA TN Knoxville
Salem Veterans Administration Medical Center Jarmukli, Nabil F USA VA Salem
Sentara York Clinical Research Lovell, Charles USA VA Norfolk
Roanoke Heart Institute, Plc Schmedtje Jr., John Frederick USA VA Roanoke
Walla Walla Clinic Ball, Eric M USA WA Walla Walla
Wenatchee Valley Medical Center Kaster, Steven R USA WA Wenatchee
Marshfield Clinic Vidaillet, Humberto J USA WI Marshfield

伦理委员会信息

名称 审查结论 审查日期
中国医学科学院阜外心血管病医院伦理委员会 修改后同意 2008-12-17

试验状态信息

试验状态
进行中-招募完成
目标入组人数
国内: 256 人; 国际: 5600 人;
已入组例数
国内: 登记人暂未填写该信息; 国际: 登记人暂未填写该信息;
实际入组总例数
国内: 登记人暂未填写该信息; 国际: 登记人暂未填写该信息;
第一例受试者签署知情同意书日期
国内:登记人暂未填写该信息;     国际:登记人暂未填写该信息;
第一例受试者入组日期
国内:2009-02-26;     国际:登记人暂未填写该信息;
试验终止日期
国内:登记人暂未填写该信息;     国际:登记人暂未填写该信息;

临床试验结果摘要

版本号 版本日期

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问题