登记号
CTR20130952
相关登记号
曾用名
药物类型
生物制品
临床申请受理号
JXSL1200006
适应症
HER2阳性晚期乳腺癌
试验通俗题目
帕妥珠单抗HER2阳性晚期乳腺癌安全性研究
试验专业题目
帕妥珠单抗联合曲妥珠单抗和紫杉烷类作为HER2阳性的晚期（乳腺癌患者的一线治疗多中心开放单组研究
试验方案编号
MO28047 （5.0版）
方案最近版本号
V6.0
版本日期
2018-11-21
方案是否为联合用药
企业选择不公示
申请人信息
申请人名称
联系人姓名
徐艳
联系人座机
021-28946023
联系人手机号
联系人Email
audrey.xu@roche.com
联系人邮政地址
上海市-上海市-上海市浦东新区龙东大道1100号 上海罗氏制药有限公司
联系人邮编
201203
临床试验信息
试验分类
安全性
试验分期
其它-新版
试验目的
评价帕妥珠单抗联合曲妥珠单抗和一种紫杉烷类的安全性和耐受性
随机化
非随机化
盲法
开放
试验范围
国际多中心试验
设计类型
单臂试验
年龄
18岁(最小年龄)至
N/A岁(最大年龄)
性别
男+女
健康受试者
无
入选标准
- 签署了经过相关的机构评审委员会（IRB）或独立伦理委员会（IEC）审批的书面知情同意。
- 男性或女性患者，年龄18岁或以上。
- 组织学或细胞学确诊并记录在案的乳腺腺癌，伴不可能根治性切除的转移性疾病或 局部复发病灶。
- 根据当地实验室对原发肿瘤和/或者如果原发肿瘤不能获得时对转移部位的评估结果，呈HER2阳性（定义为免疫组化[IHC] 3+或原位杂交[ISH]阳性）（ISH阳性的定义为HER2基因拷贝数与CEP17信号的数量之比率为2.0或以上，或者对于单探针检测，HER2基因计数大于4）。
- 至少有一个可测量的病灶，而且/或者可根据实体肿瘤疗效评价标准（RECIST）第1.1 版进行评估的不可测量疾病（附录5）。
- 东部肿瘤合作组（ECOG）体能状态为0分、1分或2分。
- 左心室射血分数（LVEF）至少50%。
- 有怀孕可能性的女性（WOCBP；绝经前或者绝经后闭经不足12个月，以及尚未接受过手术绝育的女性），血清妊娠测试阴性。
- 对于WOCBP以及伴侣为CBP而且性生活活跃的男性患者，同意在研究期间和研究治疗后至少7个月使用高度有效的非激素型避孕措施（例如手术绝育）或两种有效的非激素避孕措施（例如屏障避孕法结合杀精凝胶）（详细内容请参考第4.5.2.1节）。
- 预期寿命至少有12周。
排除标准
- 既往接受过针对转移性或局部复发疾病的全身性非激素抗癌疗法。注意:在进入研究之前，允许采用至多两线内分泌疗法治疗转移性或局部复发疾病，其中一种可与Everolimus联用。
- 从辅助或新辅助全身性非激素治疗到复发之间的无疾病间期在6个月之内。
- 既往以任何形式接受过已获批准或正在研究的抗HER2制剂作为乳腺癌的治疗，但作为辅助或新辅助治疗的曲妥珠单抗和/或拉帕替尼除外。
- 在接受曲妥珠单抗和/或拉帕替尼作为辅助或新辅助治疗过程中，出现了疾病进展。
- 既往辅助或新辅助治疗导致持续性2级或以上（NCI-CTC，第4.0版）血液毒性的病史。
- 根据计算机断层扫描（CT）或核磁共振成像（MRI）评定，具有中枢神经系统 （CNS）转移的放射学证据但未获得良好控制的患者 (症状性或需要持续皮质类固醇 治疗(例如，地塞米松)加以控制 )。 注意：发生CNS 转移的患者在接受局部治疗 (放 射，手术等) 不加抗HER2治疗之后，如果其在筛选前3个月内病情稳定的话（根据研 究者评估），则允许其参与研究。
- 目前有3级或以上的外周神经病变（NCI-CTC，第4.0版）。
- 第一次应用研究药物（给药）之前算起的过去5年内有其它恶性疾病史，但宫颈原位 癌或者基底细胞癌除外。
- 同时伴有可能导致本研究中研究药物禁忌使用的严重且不可控制或者使病人处于发 生治疗相关并发症高风险的合并疾病。
- 器官功能不良，以下列实验室结果为证据： ？ 绝对中性粒细胞计数<1,500细胞/mm3。 ？ 血小板计数<100,000细胞/mm3。 ？ 血红蛋白<9 g/dL。 ？ 总胆红素大于正常上限（ULN；除非患者有记录在案的Gilbert综合征）。 ？ AST (SGOT) 或 ALT (SGPT) >2.5 × ULN（有肝转移的患者> 5 × ULN）。 Pertuzumab—F. Hoffmann-La Roche Ltd 32/ MO28047中文方案版本 6.0，版本日期 2019年 01月 07日；基于英文方案版本 6.0，版本日期 2018年 11月 21日 ？ 碱性磷酸酶水平> 2.5 ×ULN（有肝转移的患者> 5 × ULN，或者有骨转移的患 者>10 × ULN）。 ？ 血清肌酐>2.0 mg/dL或177 μmol/L。 ？ 国际标准化比率（INR）和激活部分凝血激酶时间（aPTT）或部分凝血激酶时间 （或PTT）>1.5 × ULN（除非正在使用治疗性抗凝疗法）。
- 不受控制的高血压（收缩压>150 mmHg和/或舒张压>100 mmHg）或者具有临床意义（即活动性）的心血管疾病：第一次给药研究药物之前的6个月内有脑血管意外/中风或心肌梗死、不稳定心绞痛、纽约心脏协会（NYHA）II级或以上的充血性心力衰竭（CHF）、或需要药物治疗的严重心律失常。
- 目前有已知的HIV、乙型肝炎病毒或丙型肝炎病毒感染。
- 因晚期恶性疾病的并发症而在静息状态下有呼吸困难，或者其它需要持续氧气疗法的疾病。
- 第一次使用研究药物（给药）之前的14天内有重大的外科手术或严重外伤，或者预 期在研究治疗的过程中需要重大手术。注意：如果研究过程中需要手术治疗，应允 许受试者最少恢复14天，之后方可开始后续帕妥珠单抗和曲妥珠单抗治疗入选之前 的7天内因感染而接受过静脉抗生素。
- 目前长期使用(持续>3个月)每日的皮质激素治疗（剂量相当于或大于10 mg/天甲基 强的松龙）， 但吸入性激素除外。
- 已知对任何一种研究药物治疗或者对重组人源或人源化抗体的赋形剂过敏。
- 第一次使用研究药物（给药）之前28天内有接受过任何研究性治疗史。
- 根据研究者评估，不能够或不愿意遵守方案的要求。
- 同时参加任何干预型的临床试验。
试验分组
试验药
| 名称 | 用法 |
|---|---|
|
中文通用名:帕妥珠单抗注射液
|
用法用量:注射剂，420mg(14ml)/瓶，静脉输液。在第一个治疗周期的第1天或第2天给予840mg，接下来在后续的每一个为期3周的周期的第1天或第 2天给予420mg。
|
|
中文通用名:曲妥珠单抗注射液
|
用法用量:注射剂，440mg(20ml)/瓶，静脉输液。将在第一个治疗周期的第1天或第2天，用负荷剂量8 mg/kg以静脉输液的形式给予曲妥珠单抗，接下来在后续的每个为期3周的周期的第1天或第2天给予6mg/kg；按照已获批准的当地产品信息和/或公认的临床实践指南。
|
对照药
| 名称 | 用法 |
|---|---|
|
中文通用名:无
|
用法用量:无
|
终点指标
主要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| NCI-CTCAE4.0AEs或SAEs的发生率和严重程度;CHF的发生率;研究过程中的LVEF;实验室检验异常 | 每年 | 安全性指标 |
次要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| PFS，OS，ORR，CBR，缓解的持续时间及出现缓解的时间 | 2018年6月 | 有效性指标 |
数据安全监察委员会（DMC）
有
为受试者购买试验伤害保险
有
研究者信息
| 姓名 | 学位 | 职称 | 电话 | 邮政地址 | 邮编 | 单位名称 | |
|---|---|---|---|---|---|---|---|
| 胡夕春 | 医学博士 | 主任医师 | 13816110335 | xchu2009@hotmail.com | 上海市-上海市-上海市徐汇区东安路270号 | 200032 | 复旦大学附属肿瘤医院 |
各参加机构信息
| 机构名称 | （主要）研究者 | 国家 | 地区 | 城市 |
|---|---|---|---|---|
| 复旦大学附属肿瘤医院 | 胡夕春 | 中国 | 上海市 | 上海市 |
| 北京肿瘤医院 | 李惠萍 | 中国 | 北京市 | 北京市 |
| 江苏省肿瘤医院 | 冯继锋 | 中国 | 江苏省 | 南京市 |
| 中山大学附属肿瘤医院 | 王树森 | 中国 | 广东省 | 广州市 |
| 西安交通大学医学院第一附属医院 | 李恩孝 | 中国 | 陕西省 | 西安市 |
| 天津市肿瘤医院 | 佟仲生 | 中国 | 天津市 | 天津市 |
| 第三军医大学附属西南医院 | 姜军 | 中国 | 重庆市 | 重庆市 |
| 第四军医大学西京医院 | 李南林 | 中国 | 陕西省 | 西安市 |
| 哈尔滨医科大学附属肿瘤医院 | 张清媛 | 中国 | 黑龙江省 | 哈尔滨市 |
| CPMC; Service d'Oncologie Médicale | KAMEL BOUZID | ALGERIA | ALGIERS | Algiers |
| Centro Oncologico Riojano Integral (CORI) | Luis Kaen | ARGENTINA | LA RIOJA | La Rioja |
| Instituto de Oncología de Rosario | Luis Fein | ARGENTINA | ROSARIO | Rosario |
| AUSTIN AND REPATRIATION MEDICAL CENTRE; CANCER SERVICES | Jacqui Thomson | AUSTRALIA | Victoria | MELBOURNE |
| CANBERRA HOSPITAL; MEDICAL ONCOLOGY | ROBIN STUART-HARRIS | AUSTRALIA | Australian Capital Territory | CANBERRA |
| HOCA Chermside | Nicole McCarthy | AUSTRALIA | Queensland | Chermside |
| ROYAL MELBOURNE HOSPITAL; HEMATOLOGY AND MEDICAL ONCOLOGY | RICHARD DE BOER | AUSTRALIA | Victoria | PARKVILLE |
| Royal Prince Alfred Hospital; Medical Oncology | JANE BEITH | AUSTRALIA | New South Wales | Camperdown |
| LKH SALZBURG - UNIV. KLINIKUM SALZBURG; III. MEDIZINISCHE ABT. | RICHARD GREIL | AUSTRIA | Salzburg | Salzburg |
| LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie | HELLMUT SAMONIGG | AUSTRIA | Steiermark | GRAZ |
| UNIVERSIT？TSKLINIK FüR FRAUENHEILKUNDE; KLINIK FüR GYN？KOLOGIE IV | CHRISTIAN SINGER | AUSTRIA | WIEN | WIEN |
| KH Der Barmherzigen Schwestern; Abteilung für Innere Medizin 1 | ANDREAS PETZER | AUSTRIA | Upper Austria | LINZ |
| UNIVERSITAIR ZIEKENHUIS BRUSSEL; ONCOLOGY | JACQUES DE GREVE | BELGIUM | BRUXELLES | BRUXELLES |
| UNIVERSITAIR ZIEKENHUIS; ONCOLOGIE - CANCEROLOGIE | Veronique Cocquyt | BELGIUM | GENT | GENT |
| U.Z. GASTHUISBERG; ONCOLOGY | Hans Wildiers | BELGIUM | LEUVEN | LEUVEN |
| CHU Sart Tilman | GUY JERUSALEM | BELGIUM | LIEGE | Liège |
| Hospital Amaral Carvalho | Augusto BeatoCarlos | BRAZIL | SP | Jau |
| Hospital das Clinicas - FMUSP Ribeirao Preto | Jurandyr Moreira de Andrade | BRAZIL | SP | Ribeirao Preto |
| Hospital Perola Byington | Roberto Hegg | BRAZIL | SP | Sao Paulo |
| Hospital Sao Jose | Marceio Curz | BRAZIL | SP | Sao Paulo |
| Hospital Sao Lucas - PUCRS | Carlos Henrique Barrios | BRAZIL | RS | Porto Alegre |
| HOSPITAL SIRIO LIBANES; CENTRO DE ONCOLOGIA | Max Mano | BRAZIL | SP | Sao Paulo |
| ONCOLOGISTAS ASSOCIADOS | Gilberto Luiz Amorim | BRAZIL | RJ | Rio de Janeiro |
| BCCA - VANCOUVER ISLAND CANCER CENTRE; ONCOLOGY | Nicole Macpherson | CANADA | British Columbia | VICTORIA |
| Capital Health; QEII HSC; Oncology | DANIEL RAYSON | CANADA | Nova Scotia | Halifax |
| CHUM - HOTEL DIEU DE MONTREAL | Andre Robidoux | CANADA | Quebec | MONTREAL |
| CROSS CANCER INSTITUTE ; DEPT OF MEDICAL ONCOLOGY | ANIL ABRAHAM JOY | CANADA | Alberta | EDMONTON |
| CSSS champlain - Charles-Le Moyne | Susan Fox | CANADA | Quebec | Greenfield Park |
| GRAND RIVER REGIONAL CANCER CENTRE | Nadia Califaretti | CANADA | Ontario | Kitchener |
| McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology | LAWRENCE PANASCI | CANADA | Quebec | MONTREAL |
| SUNNYBROOK ODETTE CANCER CENTRE | SUNIL VERMA | CANADA | Ontario | Toronto |
| William Osler Health System Brampton Civic Hospital | SANDEEP SEHDEV | CANADA | Ontario | Brampton |
| HOSPITAL SOLCA PORTOVIEJO; ONCOLOGIA | Miguel Cedeao | ECUADOR | QUITO | PORTOVIEJO |
| HOSPITAL SOLCA QUITO; ONCOLOGIA | Tannia Soria | ECUADOR | QUITO | QUITO |
| Manial Specialized Hospital; Oncology | AZEEM HAMDY ABDEL | EGYPT | CAIRO | Cairo |
| NCI; ONCOLOGY DEPT | Rabab Gaafar | EGYPT | CAIRO | Cairo |
| North Estonia Medical Centre Foundation; Oncology Center | Riina Kutner | ESTONIA | TALINN | Tallinn |
| Tartu University Hospital; Clinic of Hematology and Oncology | PEETER PADRIK | ESTONIA | TARTU | Tartu |
| HELSINKI UNIVERSITY CENTRAL HOSPITAL; ONCOLOGY CLINICS | Johanna Mattson | FINLAND | HELSINKI | HELSINKI |
| SATAKUNTA CENTRAL HOSPITAL; ONCOLOGY | OUTI SAARNI | FINLAND | PORI | PORI |
| TAMPERE UNIVERSITY HOSPITAL; DEPT OF ONCOLOGY | MINNA TANNER | FINLAND | TAMPERE | Tampere |
| TURKU UNI CENTRAL HOSPITAL; ONCOLOGY CLINICS | Johanna Ruohola | FINLAND | TURKU | Turku |
| Centre Azureen De Cancerologie; Cons externes | REMY LARGILLIER | FRANCE | MOUGINS | MOUGINS |
| CENTRE CATALAN D' ONCOLOGIE | Stephanie Catala | FRANCE | PERPIGNAN | PERPIGNAN |
| CENTRE EUGENE MARQUIS; UNITE HUGUENIN | Christophe Perrin | FRANCE | RENNES | Rennes |
| Centre Georges Francois Leclerc; Oncologie 3 | Bruno Coudert | FRANCE | DIJON | Dijon |
| CENTRE HOSPITALIER FLEYRIAT; ONCOLOGIE/HEMATOLOGIE | HUBERT ORFEUVRE | FRANCE | BOURG EN BRESSE | BOURG EN BRESSE |
| Centre Leonard De Vinci;Chimiotherapie | Virginie Pottier | FRANCE | DECHY | Dechy |
| Centre Leon Berard; Departement Oncologie Medicale | THOMAS BACHELOT | FRANCE | LYON | Lyon |
| Centre Rene Huguenin; ONCOLOGIE GENETIQUE | ETIENNE BRAIN | FRANCE | SAINT CLOUD | Saint Cloud |
| Chp Saint Gregoire; Cancerologie Radiotherapie | Xavier Artignan | FRANCE | SAINT GREGOIRE | SAINT GREGOIRE |
| CLINIQUE CHENIEUX; ONCOLOGY | Dominique Genet | FRANCE | LIMOGES | Limoges |
| Institut D Oncologie Medical | Mihaela Achille | FRANCE | STRASBOURG | STRASBOURG |
| Clinique De L Europe; Radiotherapie Chimiotherapie | MICHEL GOZY | FRANCE | AMIENS | Amiens |
| Clinique Du Docteur Calabet; Cromg | Olivier Bernard | FRANCE | AGEN | Agen |
| Clinique Radio Des Dentellieres; Chimiotherapie Radiotherapie | Jessica Grosjean | FRANCE | VALENCIENNES | Valenciennes |
| CLINIQUE SAINTE MARGUERITE; ONCOLOGIE MEDICALE | JEAN-FRANCOIS BERDAH | FRANCE | HYERES | HYERES |
| Clinique Victor Hugo | Hugues Bourgeois | FRANCE | LEMANS | LeMans |
| Crlcc Paul Papin; Oncologie Medicale | Paule Augereau | FRANCE | ANGERS | Angers |
| Hopital Cochin; Unite Fonctionnelle D Oncologie | JEROME ALEXANDRE | FRANCE | PARIS | Paris |
| Ico Rene Gauducheau; Oncologie | MARIO CAMPONE | FRANCE | SAINT HERBLAIN | Saint Herblain |
| Institut Claudius Regaud; Departement Oncologie Medicale | FLORENCE DALENC | FRANCE | TOULOUSE | Toulouse |
| Institut Curie; Oncologie Medicale | VERONIQUE DIERAS | FRANCE | PARIS | Paris |
| INSTITUT PAOLI CALMETTES; ONCOLOGIE MEDICALE | Anthony Goncalves | FRANCE | MARSEILLE | Marseille |
| POLYCLINIQUE BORDEAUX NORD AQUITAINE; CHIMIOTHERAPIE RADIOTHERAPIE | NADINE DOHOLLOU | FRANCE | BORDEAUX | BORDEAUX |
| POLYCLINIQUE DE BLOIS; CHIMIOTHERAPIE AMBULATOIRE | Philippe Laplaige | FRANCE | LA CHAUSSEE ST VICTOR | La Chaussee St Victor |
| Polyclinique De Courlancy; Centre Radiotherapie Oncologie | THOMAS FACCHINI | FRANCE | REIMS | REIMS |
| Polyclinique Du Languedoc; Chimiotherapie | Andre Mathieu | FRANCE | NARBONNE | Narbonne |
| Hopital Prive Drome Ardeche; Hopital De Jour | Hugues Barletta | FRANCE | GUIHERAND GRANGES | Guilherand Granges |
| HOPITAL SAINT LOUIS; SERVICE ONCO THORACIQUE | Luis Teixeira | FRANCE | PARIS | PARIS |
| Agaplesion Diakonieklinikum Rotenburg | Tobias Hesse | GERMANY | Hesse-Darmstadt | ROTENBURG-WUEMME |
| EV. KRANKENHAUS BETHESDA; M？NCHENGLADBACH GGMBH | Raquel von Schumann | GERMANY | Nordrhein-Westfalen | M？nchengladbach |
| Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding | Hans- Joachim Lueck | GERMANY | Saxony | Hannover |
| Gyn？kologicum Bremen Prof.Dr. Willibald Schr？der | Willibald Schrader | GERMANY | Transdisciplinary programs | Bremen |
| Klinikum am Bruderwald; Frauenklinik | Roland Repp | GERMANY | Freistaat Bayern | Bamberg |
| Klinikum Esslingen Klinik f. Frauenheilkunde und Geburtshilfe | Thorsten Kuehn | GERMANY | Baden-Württemberg | Esslingen |
| Klinikum rechts der Isar - Technische Uni München; Frauenklinik & Poliklinik | Johannes Ettl | GERMANY | Freistaat Bayern | München |
| Kreiskrankenhaus Torgau Abt.Gyn？kologie und Geburtshilfe | Eike Simon | GERMANY | Saxony | Torgau |
| Nationales Centrum für Tumorerkrankungen (NCT) | Andreas Schneeweiss | GERMANY | Baden-Württemberg | Heidelberg |
| Praxis Dr. Wagner | Steffen Wagner | GERMANY | saarland | Saarbruecken |
| Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe | Bernd Christensen | GERMANY | Brandenburg | Neuruppin |
| SRH Wald-Klinikum Gera Klinik f.Frauenheilkunde und Geburtshilfe | DIRK-MICHAEL ZAHM | GERMANY | Freistaat Thüringen | Gera |
| St.-Vincenz-Krankenhaus Frauenklinik | Angelika Ober | GERMANY | LIMBURG | Limburg |
| Uniklinik Tübingen; Frauenklinik | Eva-Maria Grischke | GERMANY | Baden-Württemberg | Tübingen |
| Universitaetsklinikum des Saarlandes; Klinik f. Frauenheilkunden und Geburtshilfe | Ingolf Juhasz-Bass | GERMANY | Hesse-Darmstadt | Homburg/Saar |
| Universitatsklinikum Erlangen; Frauenklinik | Michael Lux | GERMANY | Freistaat Bayern | Erlangen |
| Universitatsklinikum Essen; Zentrum Für Frauenheilkunde | Bahriye Aktas | GERMANY | Nordrhein-Westfalen | Essen |
| Universitatsklinikum Hamburg-Eppendorf; Frauenklinik | Volkmarv Mueller | GERMANY | HAMBURG | Hamburg |
| Universitatsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe | Achim Rody | GERMANY | Holstein | Lübeck |
| AGAPLESION Markus-Krankenhaus) | Fariba Khandan | GERMANY | Hesse-Darmstadt | Frankfurt am Main |
| Papageorgiou General Hospital; Medical Oncology | GEORGE FOUNTZILAS | GREECE | THESSALONIKI | Thessaloniki |
| University General Hospital of Heraklion | Dimitris Mavroudis | GREECE | GRETE | Crete |
| UNIVERSITY HOSPITAL OF LARISSA; ONCOLOGY | CHRISTOS PAPANDREOU | GREECE | LARISSA | LARISSA |
| UNIVERSITY HOSPITAL OF PATRAS; MEDICAL ONCOLOGY | HARALABOS KALOFONOS | GREECE | PATRAS | PATRAS |
| QUEEN ELIZABETH HOSPITAL; CLINICAL ONCOLOGY | ROGER NGAN | HONG KONG | HONG KONG | HONG KONG |
| BORSOD-ABAUJ-ZEMPLEN MEGYEI KORHAZ ES EGYETEMI OKTATO KORHAZ; ONKOLOGIAI OSZTALY | Janos Revesz | HUNGARY | MISKOLC | Miskolc |
| DEBRECENI EGYETEM ORVOS ES EGESZSEGTUDOMANYI CENTRUM; ONKOLOGIAI TANSZEK | Zsolt Horvath | HUNGARY | DEBRECEN | DEBRECEN |
| FOVAROSI SZENT LASZLO KORHAZ-RENDELOINTEZET; ONKOLOGIAI OSZTALY | GYORGY BODOKY | HUNGARY | BUDAPEST | BUDAPEST |
| ORSZAGOS ONKOLOGIAL INTEZET; ONKOLOGIAI OSZTALY | ISTVAN LANG | HUNGARY | BUDAPEST | BUDAPEST |
| SZEGEDI TUDOMANYEGYETEM SZENT GYORGYI ALBERT ORVOS ES GYOGYSZERES; ONKOTERAPIAS KLINIKA | Zsuzsanna Kahan | HUNGARY | SZEGED | Szeged |
| Fov.Onk.Szt Janos Korh. E-Budai Egyesitett Korhazai | KATALIN BOER | HUNGARY | BUDAPEST | BUDAPEST |
| Assuta Medical Centre; Oncology | Irina Jiveliouk | ISRAEL | TEL AVIV | Tel Aviv |
| CHAIM SHEBA MEDICAL CENTER; ONCOLOGY DEPT | Shani Paluch-Shimon | ISRAEL | RAMAT-GAN | Ramat-Gan |
| HADASSAH EIN KAREM HOSPITAL; ONCOLOGY DEPT | Tamar PERETZ | ISRAEL | JERUSALEM | JERUSALEM |
| KAPLAN MEDICAL CENTER; ONCOLOGY INST. | NOA BEN BARUCH | ISRAEL | REHOVOT | Rehovot |
| NAHARIYA HOSPITAL; ONCOLOGY | Hadassah Goldberg | ISRAEL | NAHARIYA | NAHARIYA |
| Rabin Medical Center; Oncology Dept | SALOMON STEMMER | ISRAEL | PETACH TIKVA | PETACH TIKVA |
| RAMBAM MEDICAL CENTER; ONCOLOGY | GEORGETA FRIED | ISRAEL | HAIFA | HAIFA |
| SOROKA MEDICAL CENTER; ONCOLOGY DEPT | DAVID GEFFEN | ISRAEL | BEER SHEVA | BEER SHEVA |
| SOURASKY / ICHILOV HOSPITAL; DEPT. OF ONCOLOGY | MOSHE INBAR | ISRAEL | TEL AVIV | TEL AVIV |
| ASSAF HAROFEH; ONCOLOGY | ELLA EVRON | ISRAEL | ZERIFIN | Zerifin |
| ARCISPEDALE S.ANNA; ONCOLOGIA MEDICA | ANTONIO FRASSOLDATI | ITALY | Veneto | Cona (FE) |
| Azienda Ospedaliera Papa Giovanni XXIII;Oncologia Medica | CARLO TONDINI | ITALY | Lombardia | BERGAMO |
| Azienda Ospedaliera San Giuseppe Moscati | CESARE GRIDELLI | ITALY | Campania | Avellino |
| AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI;S.C. ONCOLOGIA MEDICA 1 | FRANCESCO DI COSTANZO | ITALY | Toscana | FIRENZE |
| AZIENDA OSPEDALIERO-UNIVERSITARIA DIPARTIMENTO INTERAZIENDALE DI ONCOLOGIA | FABIO PUGLISI | ITALY | Friuli-Venezia Giulia | UDINE |
| Azienda USL di Ravenna; Unità Operativa di Oncologia Medica | Amelia Tienghi | ITALY | Emilia-Romagna | RAVENNA |
| AZ. OSP. OSPEDALE CIVILE; U.O. DI ONCOLOGIA MEDICA ED EMATOLOGIA | LUIGI CAVANNA | ITALY | Emilia-Romagna | PIACENZA |
| Ente Ospedaliero Ospedali Galliera; S.C. Oncologia Medica | Alessandra Gennari | ITALY | Liguria | Genova |
| Fondazione Del Piemonte; Medical Oncology | Filippo Montemurro | ITALY | Piemonte | Candiolo |
| Irccs Istituto Europeo Di Oncologia (IEO) | Giuseppe Curigliano | ITALY | Lombardia | MILANO |
| Irccs Ospedale San Raffaele;Oncologia Medica | LUCA GIANNI | ITALY | Lombardia | MILANO |
| IRCCS POLICLINICO S. MATTEO - UNI PAVIA; CLINICA MEDICA I DIV. MED. INT. ONC. MEDICA E GASTROENT. | Donatella Grasso | ITALY | Lombardia | Pavia |
| OSPEDALE BELCOLLE DI VITERBO; ONCOLOGIA | LUCA MOSCETTI | ITALY | Lazio | VITERBO |
| OSPEDALE DEGLI INFERMI DI BIELLA; REPARTO ONCOLOGIA MEDICA | Alice Giacobino | ITALY | Piemonte | BIELLA |
| Ospedale Di Macerata; Oncologia | LUCIANO LATINI | ITALY | Marche | Macerata |
| OSPEDALE MAGGIORE DELLA CARITA; ONCOLOGIA MEDICA | OSCAR ALABISO | ITALY | Piemonte | NOVARA |
| OSPEDALE MATER SALUTIS; DEPT OF ONCOLOGY | ANDREA BONETTI | ITALY | Lombardia | LEGNAGO |
| OSPEDALE S. VINCENZO; ONCOLOGIA MEDICA | FRANCESCO FERRAU | ITALY | Sicilia | Taormina |
| OSPEDALI RIUNITI DI ANCONA; ONCOLOGY | STEFANO CASCINU | ITALY | Marche | ANCONA |
| American University of Beirut - Medical Center | Nagi El-Saghir | LEBANON | BEIRUT | Beirut |
| HOTEL DIEU DE FRANCE; ONCOLOGY | MARWAN GHOSN | LEBANON | BEIRUT | Beirut |
| Lithuanian University of Health. Sciences Kauno klinikos | ELONA JUOZAITYTE | LITHUANIA | KAUNAS | KAUNAS |
| UNI ONCOLOGY INST. ; CHEMO - RADIATION DEPT | EDUARDAS ALEKNAVICIUS | LITHUANIA | VILNIUS | VILNIUS |
| Cancerologia de Queretaro; Oncologia | ADRIANA DOMINGUEZ | MEXICO | Querétaro Arteaga | MEXICO |
| CENTRO MEDICO NACIONAL SIGLO XXI - IMSS; HOSPITAL DE ONCOLOGIA | Mario Aquilino Pérez Martínez | MEXICO | MEXICO CITY | MEXICO CITY |
| HOSPITAL GENERAL DE MéXICO; UNIDAD DE ONCOLOGIA | Jesus Miguel Lazaro Leon | MEXICO | MEXICO CITY | MEXICO CITY |
| HOSPITAL HMG COYOACAN | Alejandro Juarez Ramiro | MEXICO | DF | DF |
| IEM-FUCAM | FLAVIA MORALES-VASQUES | MEXICO | DF | DF |
| INSTITUTO NACIONAL DE CANCEROLOGIA; ONCOLOGY | Juan Matus Santos | MEXICO | MEXICO CITY | MEXICO CITY |
| INSTITUTO NACIONAL DE CIENCIAS MéDICAS Y DE LA NUTRICION ZUBIRáN | Yanin Chavarri Guerra | MEXICO | MEXICO CITY | MEXICO CITY |
| Medica Sur Centro Oncologico Integral | Jeronimo Rafael Rodriguez Cid | MEXICO | D.F. | D.F. |
| Institut National D'oncologie Sidi Mohammed Ben Abdellah; Anatomopathologie | HASSAN ERRIHANI | MOROCCO | RABAT | Rabat |
| ALBERT SCHWEITZER ZIEKENHUIS; INWENDIGE GENEESKUNDE | J. VAN DEN BOSCH | NETHERLANDS | DORDRECHT | DORDRECHT |
| Catharina ZKHS; Inwendige Geneeskunde Afd. | L.J.C. van Warmerdam | NETHERLANDS | Eindhoven | Eindhoven |
| IKAZIA ZIEKENHUIS; INTERNE ONCOLOGIE | F.E. de Jongh | NETHERLANDS | ROTTERDAM | ROTTERDAM |
| MARTINI ZIEKENHUIS; DEPT OF INTERNAL MEDICINE | Annette van der Velden | NETHERLANDS | GRONINGEN | GRONINGEN |
| MC HAAGLANDEN, LOCATIE ANTONIUSHOVE; INTERNE GENEESKUNDE | H.M. OOSTERKAMP | NETHERLANDS | DEN HAAG | DEN HAAG |
| MEDISCH CENTRUM ALKMAAR | Susan Vrijaldenhoven | NETHERLANDS | ALKMAAR | ALKMAAR |
| TWEE STEDEN ZIEKENHUIS - LOCATIE TILBURG; INTERNE GENEESEKUNDE | H.T.J. ROERDINK | NETHERLANDS | TIBURG | Tilburg |
| Vie Curie | A.J. van de Wouw | NETHERLANDS | WENLO | Venlo |
| Hameed Latif Hospital; Department of Oncology | Aziz Zeba | PAKISTAN | LAHORE | Lahore |
| Shaukat Khanum Memorial Cancer Hospital; Department of Oncology | Siddiqi Neelum | PAKISTAN | LAHORE | Lahore |
| Shifa International Hospital; Department of Oncology | Kamran Rashid | PAKISTAN | ISLAMABAD | Islamabad |
| Hospital Nacional LNS dela Policia Nacional del Perú. Unidad Onco; Deapartamento de Oncología | Milagros Cavero | PERU | LIMA | Lima |
| Instituto;Oncologico Miraflores | FERNANDO SALAS | PERU | LIMA | Lima |
| Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej | MAREK WOJTUKIEWICZ | POLAND | BIALYSTOK | BIALYSTOK |
| Cent.Onkologii-Instytut im. M. S-Curie, Klinika Now. Piesi i Chirurgii Rekon. | Zbigniew Nowecki | POLAND | WARSZAWA | WARSZAWA |
| Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii | TADEUSZ PIENKOWSKI | POLAND | OTWOCK | Otwock |
| Szpital Uniwersytecki w Krakowie, Oddzia？ Kliniczny Kliniki Onkologii | Krzysztof Krzemieniecki | POLAND | KRAKOW | Krakow |
| Wojewodzki Szpital Specjalistyczny im. M. Kopernika;Oddzial Chemioterapii | Ewa Kalinka-Warzocha | POLAND | LODZ | Lodz |
| ？wi？tokrzyskie Centrum Onkologii; | Jolanta Smok-Kalwat | POLAND | KIEICE | Kielce |
| Hospital da Luz; Departamento de Oncologia Medica | JOSE LUIS PASSOS COELHO | PORTUGAL | LISBOA | Lisboa |
| Hospital de Santa Maria; Servico de Oncologia Medica | Luis Costa | PORTUGAL | LISBOA | LISBOA |
| Hospital de Sao Joao; Servico de Oncologia | MARGARIDA DAMASCENO | PORTUGAL | PORTO | PORTO |
| Inst Portugues Oncologia Coim; Oncologia Medica | Gabriela Sousa | PORTUGAL | COIMBRA | Coimbra |
| IPO do Porto; Servico de Oncologia Medica | Ana Alexandra Ferreira | PORTUGAL | PORTO | PORTO |
| King Abdul Aziz Medical City, King Fahd National Guard; Oncology | OMALKHAIR ABULKHAIR | SAUDI ARABIA | RIYADH | RIYADH |
| KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE; ONCOLOGY | TAHER AL-TWEGIERI | SAUDI ARABIA | RIYADH | RIYADH |
| Institute for Oncology of Vojvodina | JASNA TRIFUNOVIC | SERBIA | SREMSKA KAMENICA | SREMSKA KAMENICA |
| Institute for Onc/Rad Serbia | Snezana Susnjar | SERBIA | BELGRADE | BELGRADE |
| INSTITUTE OF ONCOLOGY LJUBLJANA | Erika Matos | SLOVENIA | LJUBLJANA | LJUBLJANA |
| Centro Oncologico MD Anderson Internacional; Servicio de Oncologia | Antonio Gonzalez Martin | SPAIN | MADRID | MADRID |
| Clinica Universitaria de Navarra; Servicio de Oncologia | Marta Santisteban Eslava | SPAIN | NAVARRA | PAMPLONA |
| Complejo Asistencial Universitario De Burgos; Servicio de Oncologia | Maria Garcia Gonzalez | SPAIN | BURGOS | BURGOS |
| Complejo Asistencial Universitario de Leon; Servicio de Oncologia | Andres Garcia-Palomo Perez | SPAIN | LEON | LEON |
| Complejo Hospitalario de Orense; Servicio de Oncologia | Jesus Garcia Mata | SPAIN | ORENSE | ORENSE |
| Complejo Hospitalario Nuestra Se？ora de la Candelaria; Servicio de Oncologia | Pilar Lopez Alvarez | SPAIN | TENERIFE | SANTA CRUZ DE TENERIFE |
| Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia | Rafael Lopez Lopez | SPAIN | LA CORU？A | SANTIAGO DE COMPOSTELA |
| Fundacion Hospital de Alcorcon; Servicio de Oncologia | Clara Olier Garate | SPAIN | MADRID | Alcorcon |
| Fundacion Jimenez Diaz; Servicio de Oncologia | Yann Izarzugaza Peron | SPAIN | MADRID | MADRID |
| Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia | Antonio Llombart Cussac | SPAIN | VALENCIA | Valencia |
| Hospital Clínic i Provincial; Servicio de Hematología y Oncología | Ana Arance Fernandez | SPAIN | BARCELONA | Barcelona |
| Hospital Clinico Universitario de Salamanca; Servicio de Oncologia | Cesar Rodriguez Sanchez | SPAIN | SALAMANCA | SALAMANCA |
| Hospital Clinico Universitario de Valladolid; Servicio de Oncologia | Diego Soto de Prado | SPAIN | VALLADOLID | VALLADOLID |
| Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia | Nuria Ribelles Entrena | SPAIN | MALAGA | Málaga |
| Hospital de Barbastro; Servicio de Oncologia | Jesus Florian Gerico | SPAIN | HUESCA | BARBASTRO |
| Hospital de Basurto; Servicio de Oncologia | Purificacion Martinez Del Prado | SPAIN | VIZCAYA | BILBAO |
| Hospital de Cabue？es; Servicio de Oncologia | Ignacio Pelaez Fernandez | SPAIN | ASTURIAS | Gijon |
| Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia | Salvador Saura Grau | SPAIN | LAS PALMAS | LAS PALMAS DE GRAN CANARIA |
| Hospital de Jerez de la Frontera; Servicio de Oncologia | M. Del Mar Gordon Santiago | SPAIN | CADIZ | JEREZ DE LA FRONTERA |
| Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia | Agusti Barnadas Molins | SPAIN | BARCELONA | Barcelona |
| HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia | Laura Garcia Estevez | SPAIN | MADRID | Laura Garcia Estevez |
| Hospital de Navarra; Servicio de Oncologia | José Juan Illarramendi Ma？as | SPAIN | NAVARRA | José Juan Illarramendi Ma？as |
| Hospital de Rio Hortega; Servicio de Oncologia | Juan Carlos Torrego Garcia | SPAIN | VALLADOLID | Juan Carlos Torrego Garcia |
| Hospital de Sagunto; Servicio de Oncologia | Antonio Galan Brotons | SPAIN | VALENCIA | Antonio Galan Brotons |
| Hospital General de Elda; Servicio de Oncologia | Cristina Llorca Ferrandiz | SPAIN | ALICANTE | Cristina Llorca Ferrandiz |
| Hospital General Universitario de Guadalajara; Servicio de Oncologia | Alberto Arcediano Del Amo | SPAIN | GUADALAJARA | Alberto Arcediano Del Amo |
| Hospital General Universitario J.M Morales Meseguer; Servicio de Oncologia | Elisa Garcia Garre | SPAIN | MURCIA | Elisa Garcia Garre |
| Hospital Provincial de Castellon; Servicio de Oncologia | Eduardo Martinez De Due？as | SPAIN | CASTELLON | Eduardo Martinez De Due？as |
| Hospital Quiron Barcelona; Servicio de Oncologia | M. Jesus Vidal Losada | SPAIN | BARCELONA | M. Jesus Vidal Losada |
| Hospital Ramon y Cajal; Servicio de Oncologia | Noelia Martinez Ja？ez | SPAIN | MADRID | Noelia Martinez Ja？ez |
| Hospital San Pedro De Alcantara; Servicio de Oncologia | M. Helena Lopez De Ceballos | SPAIN | CACERES | M. Helena Lopez De Ceballos |
| Hospital Severo Ochoa; Servicio de Oncologia | M.Jose Echarri Gonzalez | SPAIN | MADRID | M.Jose Echarri Gonzalez |
| Hospital Universitari de Girona Dr. Josep Trueta; Servicio de Oncologia | Gemma Vi？as Vilaro | SPAIN | GIRONA | Gemma Viaas Vilaro |
| Hospital Universitario 12 de Octubre; Servicio de Oncologia | Eva Ciruelos Gil | SPAIN | MADRID | Eva Ciruelos Gil |
| Hospital Universitario Clínico San Carlos; Servicio de Oncologia | Jose Angel Garcia Saenz | SPAIN | MADRID | Jose Angel Garcia Saenz |
| Hospital Universitario Dr. Peset | Rosa M. Llorente Domenech | SPAIN | VALENCIA | Rosa M. Llorente Domenech |
| Hospital Universitario La Paz; Servicio de Oncologia | Andres Redondo Sanchez | SPAIN | MADRID | Andres Redondo Sanchez |
| HOSPITAL UNIVERSITARIO SON ESPASES | Jesus Alarcon Company | SPAIN | ISLAS BALEARES | Jesus Alarcon Company |
| Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia | Jose Luis Alonso Romero | SPAIN | MURCIA | Jose Luis Alonso Romero |
| Hospital Universitario Virgen de las Nieves; Servicio de Oncologia | Salomon Menjon Beltran | SPAIN | GRANADA | Salomon Menjon Beltran |
| Hospital Universitario Virgen Macarena; Servicio de Oncologia | Luis De La Cruz Merino | SPAIN | SEVILLA | SEVILLA |
| Hospital Universitari Sant Joan de Reus; Servicio de Oncologia | Mireia Mele Olive | SPAIN | TARRAGONA | Reus |
| Centrallasarettet V？xj？, Onkologkliniken | Ulrik Narbe | SWEDEN | VAXJO | VAXJO |
| Centralsjukhuset Karlstad, Onkologkliniken | Kilian Bachmeier | SWEDEN | KARLSTAD | KARLSTAD |
| Gavle Sjukhus; Onkologiska Kliniken | Olga Del Val Munoz | SWEDEN | GAVLE | gavle |
| Sahlgrenska Universitetssjukhuset; Jubileumskliniken | Leif Klint | SWEDEN | GaTEBORG | GaTEBORG |
| Skanes University Hospital, Sk？nes Department of Onclology | NIKLAS LOMAN | SWEDEN | LUND | Lund |
| Vastmanlands sjukhus V？ster？s, Onkologkliniken | Helena Granstam Bjarneklett | SWEDEN | VaSTERaS | VaSTERaS |
| Akdeniz University Medical Faculty; Medical Oncology Department | Coskun Hasan Senol | TURKEY | ANTALYA | Antalya |
| Baskent Uni. Practice and Research Hospital; Medical Oncology | Ozgur Ozyilkan | TURKEY | ADANA | Adana |
| Ege University Medical Faculty; Medical Oncology Department | RUCHAN USLU | TURKEY | IZMIR | IZMIR |
| HACETTEPE UNI MEDICAL FACULTY HOSPITAL; ONCOLOGY DEPT | KADRI ALTUNDAG | TURKEY | ANKARA | ANKARA |
| Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department | Irfan Cicin | TURKEY | EDIRNE | EDIRNE |
| Kyiv City Clinical Oncological Center; Chemotherapy Department | Nataliia Voitko | UKRAINE | KIEV | Kiev |
| Mun. Multifield Clin.Hosp.#4,Dept. of Chemotherapy, DSMU; Chair of Oncology and Medical Radiology | IGOR BONDARENKO | UKRAINE | Dnipropetrovsk Oblast | Dnipropetrovsk |
| State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department | Yaroslav Shparyk | UKRAINE | Lviv | Lviv |
| ZAPOROZHYE REGIONAL ONCOLOGY HOSPITAL; DEPT OF ONCOLOGY | ALEXEY KOVALEV | UKRAINE | Zaporozhye | ZAPOROZHYE |
| Tawam Hospital | Hassan Jaafar | UNITED ARAB EMIRATES | Al Ain | Al Ain |
| Addenbrookes Hospital; Dept of Oncology | Richard Baird | UNITED KINGDOM | England | Cambridge |
| Barts and the London NHS Trust. | CHRIS GALLAGHER | UNITED KINGDOM | England | LONDON |
| BEATSON WEST OF SCOTLAND CANCER CENTRE | Sophie Barrett | UNITED KINGDOM | Scottish | GLASGOW |
| Christie Hospital; Breast Cancer Research Office | ANDREW WARDLEY | UNITED KINGDOM | England | Manchester |
| Churchill Hospital | Nicola Levitt | UNITED KINGDOM | England | OXFORD |
| City Hospital NHS Trust | DAN REA | UNITED KINGDOM | England | BIRMINGHAM |
| DERRIFORD HOSPITAL; PLYMOUTH ONCOLOGY CENTRE | Stephen Kelly | UNITED KINGDOM | England | PLYMOUTH |
| Diana Princess of Wales Hosp. | Mohammed Butt | UNITED KINGDOM | England | Grimsby |
| Eastbourne District Hospital; Department of Pharmacy | Sarah Westwell | UNITED KINGDOM | England | EASTBOURNE |
| FREEMAN HOSPITAL; NORTHERN CENTRE FOR CANCER CARE | MARK VERRILL | UNITED KINGDOM | England | New Castle upon Tyne |
| HAIRMYRES HOSPITAL; ONCOLOGY DEPT | Grainne Dunn | UNITED KINGDOM | England | EAST KILBRIDE |
| HUDDERSFIELD ROYAL INFIRMARY | JOHNATHAN JOFFE | UNITED KINGDOM | England | HUDDERSFIELD |
| JAMES COOK UNI HOSPITAL | Alison Humphreys | UNITED KINGDOM | England | MIDDLESBOROUGH |
| Leeds Teaching Hosp NHS Trust;St James's Institute of Onc | TIMOTHY PERREN | UNITED KINGDOM | England | LEEDS |
| Macclesfield District General Hospital | Lisa Barraclough | UNITED KINGDOM | England | Macclesfield |
| Mount Vernon Cancer Centre | DAVID MILES | UNITED KINGDOM | England | Northwood, Essex |
| Musgrove Park Hospital | Mohini Varughese | UNITED KINGDOM | England | Somerset |
| Peterborough City Hospital | KAREN MCADAM | UNITED KINGDOM | England | Peterborough |
| Royal Cornwall Hospital | DUNCAN WHEATLEY | UNITED KINGDOM | England | Truro |
| ROYAL DERBY HOSPITAL | Prabir Chakraborti | UNITED KINGDOM | England | Derby |
| ROYAL FREE HOSPITAL; DEPT OF ONCOLOGY | ALISON JONES | UNITED KINGDOM | England | LONDON |
| Royal Marsden Hospital | Nicholas Turner | UNITED KINGDOM | England | London |
| Royal Surrey County Hospital | ROBERT LAING | UNITED KINGDOM | England | GUILDFORD |
| Royal United Hospital; Oncology Department | Mark Beresford | UNITED KINGDOM | England | Bath |
| Wishaw General Hospital | Jonathan Hicks | UNITED KINGDOM | England | Glasgow |
| The Royal Marsden Hospital | Nicholas Turner | UNITED KINGDOM | England | SUTTON |
| University Hospital of North Durham | Wendy Taylor | UNITED KINGDOM | England | Durham |
| Velindre Hospital | Peter J. BARRETT-LEE | UNITED KINGDOM | England | Cardiff |
| WALSGRAVE HOSPITAL | CHRIS POOLE | UNITED KINGDOM | England | COVENTRY |
| Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología | Cecilia Castillo | URUGUAY | MONTEVIDEO | Montevideo |
| Hospital Central De Las FF.AA.; Servicio De Oncologia | Robinson Rodriguez | URUGUAY | MONTEVIDEO | Montevideo |
| Hospital Pereira Rossell; Oncology Department | Isabel Alonso | URUGUAY | MONTEVIDEO | Montevideo |
| Centro Integral de Oncología | Gassan Yordi | VENEZUELA | CARACAS | CARACAS |
| Centro Médico Docente La Trinidad; Servicio de Gastroenterología | RAúLVERA | VENEZUELA | CARACAS | CARACAS |
| Instituto Oncológico Luis Razetti | Juan JoseRodriguez | VENEZUELA | CARACAS | CARACAS |
| ANTICANCER HOSPITAL AG. SAVAS ; 2ND DEPT. OF ONCOLOGY - INTERNAL MEDICINE | Georgios Koumakis | GREECE | ATHENS | ATHENS |
| Euromedical General Clinic of Thessaloniki; Oncology Department | Konstantinos Papazisis | GREECE | THESSALONIKI | Thessaloniki |
| HIPPOKRATIO HOSPITAL; 2ND INTERNAL MEDICINE | DIMITRIOS PECTASIDES | GREECE | ATHENS | Athens |
伦理委员会信息
| 名称 | 审查结论 | 审查日期 |
|---|---|---|
| 第三军医大学附属西南医院 | 同意 | 2013-04-15 |
| 哈尔滨医科大学附属肿瘤医院 | 修改后同意 | 2013-04-25 |
| 江苏省肿瘤医院 | 同意 | 2013-04-25 |
| 北京肿瘤医院 | 修改后同意 | 2013-05-14 |
| 天津市肿瘤医院 | 同意 | 2013-05-31 |
| 复旦大学附属肿瘤医院伦理委员会 | 修改后同意 | 2013-06-03 |
| 中山大学附属肿瘤医院 | 修改后同意 | 2013-06-27 |
| 西安交通大学医学院第一附属医院 | 同意 | 2013-06-28 |
| 第四军医大学西京医院 | 修改后同意 | 2013-07-24 |
| 复旦大学附属肿瘤医院伦理委员会 | 同意 | 2019-05-14 |
试验状态信息
试验状态
已完成
目标入组人数
国内: 50 ；
国际: 1500 ；
已入组例数
国内: 52 ；
国际: 1436 ；
实际入组总例数
国内: 52 ；
国际: 1436 ；
第一例受试者签署知情同意书日期
国内：2013-06-21；
国际：2012-05-30；
第一例受试者入组日期
国内：2013-06-21；
国际：2012-06-01；
试验终止日期
国内：2019-12-11；
国际：2019-12-11；
临床试验结果摘要
| 版本号 | 版本日期 |
|---|
