登记号
CTR20130027
相关登记号
曾用名
药物类型
化学药物
临床申请受理号
企业选择不公示
适应症
急性冠脉综合征（ACS）
试验通俗题目
在有ACS的T2DM患者中评价lixisenatide治疗期间的心血管结局
试验专业题目
一项在发生ACS的T2DM患者中评价lixisenatide治疗期间心血管结局的随机、双盲、安慰剂对照、平行分组的多中心研究
试验方案编号
EFC11319 方案修正案3
方案最近版本号
版本日期
方案是否为联合用药
企业选择不公示
申请人信息
申请人名称
联系人姓名
赛诺菲
联系人座机
021-22266622
联系人手机号
联系人Email
Contact-US.CN@sanofi.com
联系人邮政地址
上海市静安区延安中路1228号静安嘉里中心办公楼3座17楼中国临床研究中心
联系人邮编
200040
临床试验信息
试验分类
安全性和有效性
试验分期
III期
试验目的
在刚经历ACS事件的T2DM患者中，评价lixisenatide与安慰剂比较是否可降低心血管发病率和死亡率，以及评价lixisenatide的安全性和耐受性
随机化
随机化
盲法
双盲
试验范围
国际多中心试验
设计类型
平行分组
年龄
30岁(最小年龄)至
N/A岁(最大年龄)
性别
男+女
健康受试者
无
入选标准
- 经历自发ACS事件（即ST段抬高性心肌梗死、非ST段抬高性心肌梗死或不稳定性心绞痛）、存在记录明确的心脏生物标记物（肌钙蛋白或心肌酶）高于正常范围、存在与ACS一致的临床表现且导致在事件发生后180日内和筛选前进入急症监护设施的男性和女性。在事件发生后180日内筛选入组。
- 在筛选访视前有T2DM病史的患者（对于新诊断的患者，诊断必须依据WHO标准：即筛选前已有2次检验，确认空腹静脉血浆葡萄糖浓度≥7.0 mmol/L [126 mg/dL]或糖负荷后2小时静脉血浆葡萄糖≥11.1 mmol/L [200 mg/dL]）。
排除标准
- 1型糖尿病患者或者筛选前6个月内有酮酸中毒的既往史
- 筛选访视时检测的HbA1c<5.5%或>11%
- 双盲治疗期必需使用除研究用药外的肠促胰岛素类降糖药（如GLP-1受体激动剂或DPP-4抑制剂）
- 在符合条件的ACS事件后接受了冠状动脉旁路移植术（CABG）
- 筛选前15日内接受了经皮冠状动脉介入治疗（PCI）
- 删选后90日内计划接受血运重建术（PCI或CABG）
- 有无原因的胰腺炎、慢性胰腺炎、胰切除术、胃部手术、炎症性肠病病史、甲状腺髓样癌（MTC）病史或家族史、或MTC易感的遗传因素（如多发性内分泌腺瘤）
- 在筛选时由主要研究者或副研究者判定会影响患者安全完成试验或影响终点评价的临床显著异常，例如重大系统性疾病。
试验分组
试验药
| 名称 | 用法 |
|---|---|
|
中文通用名:Lixisenatide（AVE0010）
|
用法用量:注射液，100 μg活性成分每mL溶液；规格3 mL每瓶；皮下注射；最初2周0.10 mL QD，之后增加至0.20 mL QD（早餐前1小时内使用）；用药时程：14至约41个月。
|
对照药
| 名称 | 用法 |
|---|---|
|
中文通用名:安慰剂
|
用法用量:注射液，无活性成分溶液；规格3 mL每瓶；皮下注射；最初2周0.10 mL QD，之后增加至0.20 mL QD（早餐前1小时内使用）；用药时程：14至约41个月。
|
终点指标
主要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 首次发生经CAC裁定确认的主要CV事件（CV死亡、非致命性MI、非致命性卒中、UA导致的住院）的时间 | 0至第203周 | 有效性指标 |
次要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 首次发生经CAC裁定确认的CV死亡、非致命性MI、非致命性卒中、UA导致的住院、心衰导致的住院的时间 | 0至第203周 | 有效性指标 |
| 尿白蛋白/肌酐比的变化量（%） | 基线至108周 | 有效性指标 |
| 首次发生经CAC裁定确认的CV死亡、非致命性MI、非致命性卒中、UA导致的住院、心衰导致的住院、冠脉血运重建术的时间 | 0至第203周 | 有效性指标 |
数据安全监察委员会（DMC）
有
为受试者购买试验伤害保险
有
研究者信息
| 姓名 | 学位 | 职称 | 电话 | 邮政地址 | 邮编 | 单位名称 | |
|---|---|---|---|---|---|---|---|
| 陆菊明 | 主任 | 13911682036 | Lujuming301@126.com | 中国北京市海淀区复兴路28号中国人民解放军总医院 | 100853 | 中国人民解放军总医院 |
各参加机构信息
| 机构名称 | （主要）研究者 | 国家 | 地区 | 城市 |
|---|---|---|---|---|
| 中国人民解放军总医院 | 陆菊明 | 中国 | 北京 | 北京 |
| 苏州大学附属第一医院 | 蒋彬 | 中国 | 江苏 | 苏州 |
| 北京同仁医院 | 杨金奎 | 中国 | 北京 | 北京 |
| 北京医院 | 杨杰孚 | 中国 | 北京 | 北京 |
| 大连医科大学附属第一医院 | 杜建玲 | 中国 | 辽宁 | 大连 |
| 南京大学医学院附属鼓楼医院 | 徐标 | 中国 | 江苏 | 南京 |
| 上海长征医院 | 石勇铨 | 中国 | 上海 | 上海 |
| 中国人民解放军第二炮兵总医院 | 胡桃红 | 中国 | 北京 | 北京 |
| 济南市中心医院 | 苏国海 | 中国 | 山东 | 济南 |
| 北京安贞医院 | 马长生 | 中国 | 北京 | 北京 |
| 上海市第一人民医院 | 彭永德 | 中国 | 上海 | 上海 |
| 中山大学附属第一医院 | 董吁钢 | 中国 | 广东 | 广州 |
| 辽宁省人民医院 | 李占全 | 中国 | 辽宁 | 沈阳 |
| 齐鲁医院 | 陈丽 | 中国 | 山东 | 济南 |
| 北京大学第一医院 | 郭晓蕙 | 中国 | 北京 | 北京 |
| 阜外心血管医院 | 杨艳敏 | 中国 | 北京 | 北京 |
| 中国医科大学附属盛京医院 | 韩萍 | 中国 | 辽宁 | 沈阳 |
| 新疆医科大学第一附属医院 | 汤宝鹏 | 中国 | 新疆 | 乌鲁木齐 |
| 中日友好医院 | 柯元南 | 中国 | 北京 | 北京 |
| Cardiology Center Craiova | Octavian Istratoaie | Romania | NA | Craiova |
| Cardiomed SRL | Constantin Militaru | Romania | NA | Craiova |
| SC Diabol SRL | MD Ioana Emilia Emilia Ferariu | Romania | NA | Brasov |
| Emergency County Hospital Deva | DrMed Rodica Ioana AVRAM | Romania | NA | Deva |
| Spitalul Universitar De Urgenta Bucuresti | Dragos Vinereanu | Romania | NA | Bucuresti |
| Rocordis SRL | Gabriel Ivanica | Romania | NA | Timisoara |
| Spitalul Judetean De Urgenta Braila | Bogdan Minescu | Romania | NA | Braila |
| Institute 'N Paulescu' | Radu Lichiardopol | Romania | NA | Bucuresti |
| Heart Institute 'N Stancioiu' Cluj | PR Adrian-Corneliu Iancu | Romania | NA | Cluj Napoca |
| Timisoara Emergency County Clinical Hospital | MD DOINA - ROSU | Romania | NA | Timisoara |
| Spitalul Judetean Pitesti | DrMed,MD Adrian G Tase | Romania | NA | Pitesti |
| Unitas Hospital | MD I O Ebrahim | South Africa | NA | Pretoria |
| Clinical Research Unit University of Pretoria | MD Eluned Delport | South Africa | NA | Pretoria |
| Dr. L van Zyl, Private Practice | Louis VAN ZYL | South Africa | NA | Worcester |
| The Bay Hospital | DrMed,MD Dudley Martin-Leake Kelbe | South Africa | NA | Richards Bay |
| Karl Bremer Hospital | Mirna SIEBERT | South Africa | NA | Cape Town |
| Helderberg Clinical Trials Centre | BS,MD Graham Ellis | South Africa | NA | Somerset West |
| Dr PJ Sebastian Private Practice | Peter John SEBASTIAN | South Africa | NA | Chatsworth |
| 311 Gatesville Medical Centre | SIDDIQUE ISMAIL | South Africa | NA | Cape Town |
| Sunninghill Hospital | Eric Klug | South Africa | NA | Rivonia |
| Paarl Research Centre | BS,MD Kathleen Coetzee | South Africa | NA | Paarl |
| Excellentis Clinical Trail Consultants | MD susan arnold | South Africa | NA | George |
| Vincent Palotti Hospital | MD Saleem Yunas Dawood | South Africa | NA | Cape Town |
| Arwyp Medical Suites Building | Ilse Elizabeth Kapp | South Africa | NA | Kempton Park |
| Cardiology Clinical Research | MD Tjaart P Venter | South Africa | NA | Alberton |
| Tygerberg Academic Hospital | PhD Prof Lesley Jean Burgess | South Africa | NA | Parow |
| Groote Schuur Hospital | MD Mpiko Ntsekhe | South Africa | NA | Cape Town |
| Hopital Militaire | Borni Zidi | Tunisia | NA | Tunis |
| Hopital Militaire | DrMed Habib HAOUALA | Tunisia | NA | Tunis |
| Hopital Hedi Chaker | DrMed,MD Mohamed Abid | Tunisia | NA | Sfax |
| Hopital La Rabta | Hedia SLIMANE | Tunisia | NA | Tunis |
| Hopital Charles Nicolle | MD Nejib Ben Abdallah | Tunisia | NA | Tunis |
| St Franciscus Gasthuis | Peter Nierop | Netherland | NA | Rotterdam |
| Amphia Ziekenhuis Molengracht | Phjm Dunselman | Netherland | NA | Breda |
| St Elisabeth Ziekenhuis | DrMed Wrm Hermans | Netherland | NA | Tilburg |
| Vasculair Onderzoeks Centrum BV | MD Paulus Dekkers | Netherland | NA | Hoorn |
| Medisch Centrum Alkmaar | MD Jan Hein Cornel | Netherland | NA | Alkmaar |
| VieCuri Medisch Centrum Voor Noord-Limburg | DrMed Joan Meeder | Netherland | NA | Velno |
| Bronovo Ziekenhuis | MD Nicole Knufman | Netherland | NA | Den Haag |
| Deventer Ziekenhuis | MD Dirk Lok | Netherland | NA | Deventer |
| Bispebjerg Hospital | DrMed Henrik Nielsen | Denmark | NA | Kobenhavn |
| Gentofte Hospital | Christian Torp-Pedersen | Denmark | NA | Hellerup |
| Aarhus Sygehus, Tage-H | Steen Husted | Denmark | NA | Aarhus |
| Sygehus Himmerland Farso | MD Henning Spiger Ronne | Denmark | NA | Farso |
| Hvidovre Hospital | MD Soeren Lind Rasmussen | Denmark | NA | Hvidovre |
| Rigshospitalet | Lars Kober | Denmark | NA | Kobenhavn |
| Hillerod Hospital | DrMed Peter Kaiser Nielsen | Denmark | NA | Hillerod |
| Aarhus Universitets hospital, Aarhus Sygehus, Norrebrogade | Jorgen Rungby | Denmark | NA | Aarhus |
| Herlev Hospital | DrSc,MD Knud Skagen | Denmark | NA | Herlev |
| Sydvestjysk Sygehus Esbjerg | MSc,MD Kristian Korsgaard Korsgaard Thomsen | Denmark | NA | Esbjerg |
| Sygehus Lillbaelt, Kolding | PhD,MS,MD Kim Houlind | Denmark | NA | Kolding |
| SA Pohja-Eesti Regionaalhaigla | MD Anu Ambos | Estonia | NA | Tallinn |
| Mustamae Tervisekeskus OU | MD Kaja Martsin | Estonia | NA | Tallinn |
| Perearst Svea Rosenthal OU | Svea Rosenthal | Estonia | NA | Tallinn |
| AS Ida-Tallinna Keskhaigla | Ulle Jakovlev | Estonia | NA | Tallinn |
| SA Tartu Ulikooli Kliinikum | Maire Lubi | Estonia | NA | Tartu |
| SA Viljandi Haigla | Hella Vides | Estonia | NA | Viljandimaa |
| Vilnius University Hospital Santariskiu klinikos | Zaneta Petrulioniene | Lithuania | NA | Vilnius |
| Hospital of Lithuanian University of Health Sciences | Gintare Sakalyte | Lithuania | NA | Kaunas |
| Saules Family Medicine Center | MD Audrone Urboniene | Lithuania | NA | Kaunas |
| Clinic of Cardiology and rehabilitation | Roma Kavaliauskiene | Lithuania | NA | Klaipeda |
| Mano Gydytojas,UAB | Vaida Kakariekiene | Lithuania | NA | Panevezys |
| A. Navickas Consultancy Outpatient Clinic | Rima Zarankiene | Lithuania | NA | Klaipeda |
| Regional Hospital of Daugavpils | Jelena Sokolova | Latvia | NA | Daugavpils |
| Regional Hospital of Liepaja | Iveta Sime | Latvia | NA | Liepaja |
| Pauls Stradins Clinical University Hospital | Professor Valdis Pirags | Latvia | NA | Riga |
| Riga East Clinical Research Institute | MD Ilze Konrade | Latvia | NA | Riga |
| Physician Practice of Endocrinology | Ildze Amolina | Latvia | NA | Cesis |
| Riga Region Hospital, Outpatient Clinic | MD Renate Helda | Latvia | NA | Sigulda |
| LUMPII Medical Practice | MD Kristine Ducena | Latvia | NA | Riga |
| Centrallasarettet Vaxjo | MD Peter Vasko | Sweden | NA | Vaxjo |
| Sodersjukhuset | Gunnar Boberg | Sweden | NA | Stockholm |
| Lasarettet i Ljungby | DrMed Karl-Axel Svensson | Sweden | NA | Ljungby |
| Danderyds sjukhus AB | DrMed,MD Gun Jorneskog | Sweden | NA | Stockholm |
| Oskarshamns Sjukhus | Ulrik Mathiesen | Sweden | NA | Oskarshamn |
| Centralsjukhuset Kristianstad | Ingemar Torstensson | Sweden | NA | Kristianstad |
| Centralsjukhuset Karlstad | Johan H Jendle | Sweden | NA | Karlstad |
| Stavanger Helseforskning AS | MD John Cooper | Norway | NA | Stavanger |
| Helse Fonna Haugesund Sjukehus | DrMed Bjrn Gunnar Nedrebo | Norway | NA | Haugesund |
| Nordlandssykehuset HF Bodo | Knut Tore Lappegard | Norway | NA | Bodo |
| Rauman Erikoislaakarikeskus | Pirkko Korsoff | Finland | NA | Rauma |
| Keski-Suomen keskussairaala | Anna-Mari Koski | Finland | NA | Jyvaskyla |
| Valkeakosken aluesairaala | MD Juha Alanko | Finland | NA | Valkeakoski |
| Turun Yliopistollinen keskussairaala | MD Lassi Nelimarkka | Finland | NA | Turku |
| FinnMedi Oy | DrMed,PhD Jorma Tapani Lahtela | Finland | NA | Tampere |
| Vantaan tutkimuskeskus | DrMed Jaakko Tuomilehto | Finland | NA | Vantaa |
| Dedinje Cardiovascular Institute | Petar Otasevic | Serbia | NA | Belgrade |
| Clinic for Endocrinology, Diabetes and Metabolic Diseases | Dragan Micic | Serbia | NA | Belgrade |
| Clinic for Endocrinology, Diabetes and Metabolic Diseases | Nebojsa Lalic | Serbia | NA | Belgrade |
| CC Serbia, Clinic of cardiology | DrSc Goran Stankovic | Serbia | NA | Belgrade |
| Clinical Center Nis | Radivoj Kocic | Serbia | NA | Nis |
| Clinical Hospital Center Zvezdara | MS MD Marina Andjelic Jelic | Serbia | NA | Belgrade |
| Clinical Center Nis | Milica Pesic | Serbia | NA | Nis |
| CC Serbia, Emergency Center | MD Snezana Komnenovic | Serbia | NA | Belgrade |
| Clinic for Endocrinology, Diabetes and Metabolic Diseases | Petar Seferovic | Serbia | NA | Belgrade |
| Clinic for Endocrinology, Diabetes and Metabolic Diseases | DrMed,DrSc Katarina Lalic | Serbia | NA | Belgrade |
| Gachon University Gil Hospital | DrMed Wook Jin CHUNG | Korea | NA | Incheon |
| Gangnam Severance Hospital | SeJoong RIM | Korea | NA | Seoul |
| Korea University Anam Hospital | Sin Gon Kim | Korea | NA | Seoul |
| Seoul National University Bundang Hospital | Hakchul Jang | Korea | NA | Seongnam |
| YeungNam University Hospital | DrMed,MD Ung kim | Korea | NA | Daegu |
| Wonju Christian Hospital | DrMed Choon Hee Chung | Korea | NA | Wonju |
| Inha University Hospital | Sung-Hee SHIN | Korea | NA | Incheon |
| Chonnam National University Hospital | KyeHun KIM | Korea | NA | Gwangju |
| Chung-Ang University Hospital | jaetaek kim | Korea | NA | Seoul |
| Korea University Guro Hospital | SeungWoon Rha | Korea | NA | Seoul |
| Soonchunhyang University Bucheon Hospital | Nae Hee lee | Korea | NA | Bucheon |
| KyungHee University Hospital at Gangdong | MD Chong-Jin KIM | Korea | NA | Seoul |
| Seoul National University Hospital | DrMed Kyong Soo Park | Korea | NA | Seoul |
| Hospital Nuestra Senora De Valme | PhD SANTIAGO DURAN GARCIA | Spain | NA | Sevilla |
| Complexo Hospitalario Motecelo De Pontevedra | DrMed,MD ELENA ALONSO | Spain | NA | Pontevedra |
| Hospital Povisa | Javier De la Fuente | Spain | NA | Pontevedra |
| Hospital Príncipe De Asturias | Marta Botella | Spain | NA | Madrid |
| Hospital Universitari Arnau De Vilanova | Dr Mauricio/ Dra Marta Hernandez | Spain | NA | Lerida |
| Hospital La Paz | Isabel Antorrena | Spain | NA | Madrid |
| COMPLEXO HOSPITALARIO UNIVERSITARIO A CORUNA | Alfonso Soto Gonzalez | Spain | NA | La Coruna |
| Hospital de Basurto | MD Jose Ramon Elorza | Spain | NA | Bilbao |
| Hospital San Pedro de Alcantara | MD Fidel J Enciso | Spain | NA | Caceres |
| Hospital Virgen del Mar | DrMed Manuel Vida | Spain | NA | Almeria |
| Hospital Virgen de la Arrixaca | DrMed Francisco Marin | Spain | NA | Murcia |
| Hospital Clínic i Provincial | Victoria Martin | Spain | NA | Barcelona |
| Hospital Clínico Universitario | DrMed Vicent Bodi | Spain | NA | Valencia |
| Hospital Central de Asturias | DrMed Elias Delgado | Spain | NA | Oviedo |
| Centre Hospitalier Gilles De Corbeil | DrMed CATHERINE PETIT | France | NA | Corbeil Essonnes |
| HOPITAL NORD LAENNEC - Saint Herblain | MD Bertrand CARIOU | France | NA | Nantes |
| Hopital Europeen Georges POMPIDOU | DrMed Roxane DUCLOUX | France | NA | Paris |
| CHU Hopital De La Cavale Blanche | Veronique KERLAN | France | NA | Brest |
| CHU De Bordeaux - Haut Leveque | MD Bogdan CATARGI | France | NA | Pessac |
| CHU De Poitiers | DrMed Samy HADJADJ | France | NA | Poitiers |
| Hopital Caremeau | DrMed michel rodier | France | NA | Nimes |
| Wolfson Mc | Julio Wainstein | Israel | NA | Holon |
| Rambam MC | Deeb Daoud | Israel | NA | Haifa |
| Sheba MC | Jacob Iiany | Israel | NA | Tel HaShomer |
| Tel Aviv Sourasky MC | Naftali STERN | Israel | NA | Tel Aviv |
| Ziv Medical Center | M.D. Faiad Adawi | Israel | NA | Safed |
| Geffen Cardiac Health Center | DrMed Eliezer Klainman | Israel | NA | Givatayim |
| Rambam MC | Naim Shehadeh | Israel | NA | Haifa |
| Lyn Clinic | Ladislav Slezak | Israel | NA | Haifa |
| Assaf Harofe Medical Center | Shai Efrati | Israel | NA | Tzrifin |
| Haemek Medical Center | DrMed Yoav Turgeman | Israel | NA | Afula |
| Western Galilee Medical Center | MD Shaul Atar | Israel | NA | Nahariya |
| Hadassah Ein Kerem MC | Ofri Mosenzon | Israel | NA | Jerusalem |
| Centro Hospitalar de Lisboa Ocidental / Hospital Egas Moniz | Joao Sequeira Duarte | Portugal | NA | Lisboa |
| Hospitais Da Universidade De Coimbra | Manuela Carvalheiro | Portugal | NA | Coimbra |
| Hospitais Da Universidade De Coimbra | Pedro Monteiro | Portugal | NA | Coimbra |
| Hospital Infante D Pedro | Carlos Pereira | Portugal | NA | Aveiro |
| Hospital Fernando Fonseca | Nuno Braganca | Portugal | NA | Amadora |
| Hospital De S. Joao | MD Elisabete Rodrigues | Portugal | NA | Porto |
| Hospital Padre Americo - Vale Do Sousa | MD Margarida Vinhas | Portugal | NA | Penafiel |
| Cliniques Universitaires Saint-Luc | MD Anne-Catherine Pouleur | Belgium | NA | Bruxelles |
| CHR Clinique Saint-Joseph - Hopital de Warquignies | IdesMichel Colin | Belgium | NA | Mons |
| UZ Leuven UZ Gasthuisberg | chantal mathieu | Belgium | NA | Leuven |
| MHAT Kazanluk | Mariya LUCHEVA | Bulgaria | NA | Kazanluk |
| MHAT Yulia Vrevska - Byala | Viktor Yordanov | Bulgaria | NA | Byala |
| MHAT Kaspela EOOD | MD Georgi Levterov | Bulgaria | NA | Plovdiv |
| UMHAT dr Georgi Stranski | Maria Lubomirova Tzekova | Bulgaria | NA | Pleven |
| DCC Equita EOOD | Neli Klyuchkova | Bulgaria | NA | Varna |
| MHAT Prof.Dr.P.Stoyanov | Alexy Delchev | Bulgaria | NA | Lovech |
| MHAT Sveti Georgi | Mariya Tokmakova | Bulgaria | NA | Plovdiv |
| MMA HAT Sofia | Valentin Ivanov | Bulgaria | NA | Sofia |
| MHAT Dr. Tota Venkova AD | Rositsa Shumkova | Bulgaria | NA | Gabrovo |
| MHAT Tokuda Hospital Sofia | Ivo Petrov | Bulgaria | NA | Sofia |
| Shatcardvascd | MD Nina Gotcheva | Bulgaria | NA | Sofia |
| MHAT sveta Sofia | DrMed Michael Edmond Kyoleyan | Bulgaria | NA | Sofia |
| MHAT Sveti Vrach EOOD | Dimitar RAEV | Bulgaria | NA | Sandanski |
| Tameside General Hospital | Edward Jude | United Kingdom | NA | Ashton-Under-Lyne |
| Coventry And Warwickshire Hospital | MD sudhesh kumar | United Kingdom | NA | Coventry |
| Diabetes Research Unit | Beverley Millward | United Kingdom | NA | Plymouth |
| Bradford Royal Infirmary | Donald Whitelaw | United Kingdom | NA | Bradford |
| North Manchester General Hospital | BS,DrMed,MD,MRCP Philip Wiles | United Kingdom | NA | Manchester |
| Hope Hospital | Martin Gibson | United Kingdom | NA | Salford |
| Western Infirmary | Chris Sainsbury | United Kingdom | NA | Galsgow |
| The Royal Oldham Hospital | PhD,MD Deepak Bhatnagar | United Kingdom | NA | Oldham |
| Harrogate District Hospital | DrMed Peter Hammond | United Kingdom | NA | Harrogate |
| Dumfries And Galloway Royal Infirmary | DrMed,MD Ewan Bell | United Kingdom | NA | Dumfries |
| St Mary's Hospital | Michael Yee | United Kingdom | NA | London |
| Royal Blackburn Hospital | Shenaz Ramtoola | United Kingdom | NA | Blackburn |
| Torbay Hospital | Richard Paisey | United Kingdom | NA | Torquay |
| Royal Cornwall Hospital | MRCP Duncan Browne | United Kingdom | NA | Truro |
| Royal United Hospital | Anthony Robinson | United Kingdom | NA | Bath |
| Taunton & Somerset Hospital | Robert Andrews | United Kingdom | NA | Taunton |
| Yeovil District Hospital | PhD,FRCPC Alex Bickerton | United Kingdom | NA | Yeovil |
| george elliot | DrMed,PhD,MD Ponnusamy Saravanan | United Kingdom | NA | Nuneaton |
| Wythenshawe Hospital | Basil Issa | United Kingdom | NA | Manchester |
| Whipps Cross Universtiy Hospital | David Levy | United Kingdom | NA | Leytonstone |
| Edinburgh Royal Infirmary | Alan Jaap | United Kingdom | NA | Edinburgh |
| Chorley & South Ribble District Hospital | Satyan Rajbhandari | United Kingdom | NA | Chorley |
| North Devon District Hospital | Alastair Watt | United Kingdom | NA | Barnstaple |
| University Hospital Of Aintree | John Wilding | United Kingdom | NA | Liverpool |
| Forth Valley Royal Hospital | DrMed Chris Kelly | United Kingdom | NA | larbert |
| Brimingham Heartlands Hospital | MBA,MD,MRCP jayadave shakher | United Kingdom | NA | Birmingham |
| Manchester Royal Infirmary | rayaz malik | United Kingdom | NA | Manchester |
| Countess of Chester Hospital NHS Foundation Trust | Franklin Joseph | United Kingdom | NA | Chester |
| Morriston Hospital | Stephen Bain | United Kingdom | NA | Swansea |
| Sandwell General Hospital | Douglas A Robertson | United Kingdom | NA | West Bromwich |
| Altnagelvin Hospital | M O'Kane | United Kingdom | NA | Londonderry |
| Ipswich Hospital Nhs Trust | MD,MRCP Gerry Rayman | United Kingdom | NA | Ipswich |
| Royal Liverpool Hospital | DrMed Tejpal Purewal | United Kingdom | NA | Liverpool |
| Area Antrim Hospital | DrMed Desmond Patrick Rooney | United Kingdom | NA | Antrim |
| Queen Elizabeth Hospital | DrMed,MD,MRCP Jonathan Webber | United Kingdom | NA | Birmingham |
| Hairmyres Hospital | DrMed,FRCPC,MS Babu Mukhopadhyay | United Kingdom | NA | East Kilbridge |
| City General Hospital | fahmy hanna | United Kingdom | NA | Stoke-On-Trent |
| New Cross Hospital / Deansley Centre | Baldev Singh | United Kingdom | NA | Wolverhampton |
| Hospital Of St Cross | MD Joseph Paul O'Hare | United Kingdom | NA | Rugby |
| West Wales Hospital | MRCP Atir Sultan Ali Khan | United Kingdom | NA | Carmarthen |
| Norfolk And Norwich Hospital | BS,PhD,MD,MRCP jeremy turner | United Kingdom | NA | Norwich |
| Royal Glamorgan Hospital | Philip Evans | United Kingdom | NA | Llantrisant |
| Bolton Diabetes Centre | DrMed Ambar Basu | United Kingdom | NA | Bolton |
| Sandwell General Hospital | Douglas A Robertson | United Kingdom | NA | West Bromwich |
| Ain Shams University Hospitals | Salah SHELBAYA | Egypt | NA | Cairo |
| New Alexandria University Hospitals | Samir Assaad | Egypt | NA | Alexandria |
| Bangalore Clinisearch | MBBS, MD, DIPLOMA DIABETOLOGY Paramesh Shamanna | India | NA | Bangalore |
| Apollo Gleneagles | Sanjay Chatterjee | India | NA | Kolkata |
| Gandhi Endocrinology & Diabetes Centre | Dr Pramod Dharnidharji Gandhi | India | NA | Nagpur |
| Dayanand Medical College And Hospital | Paminder Singh | India | NA | Ludhiana |
| Lifecare Clinic and research center | lakshminarayanappa sreenivasamurthy | India | NA | Bangalore |
| Fortis Heart Institute & Multifacility Hospital | Kiranpal SINGH | India | NA | Chandigarh |
| Max Super Speciality Hospital | Sujeet Jha | India | NA | new Delhi |
| Chhatrapati Shahuji Maharaj Medical University, | Dr Sudhanshu Kumar Dwivedi | India | NA | Lucknow |
| M V Hospital and Research Center | SANDEEP KUMAR GUPTA | India | NA | Lucknow |
| Amrita Institute Of Medical Sciences | Arun Chankramath Somasekharan | India | NA | Cochin |
| Medanta - The Medicity | DrMed Vijay K Chopra | India | NA | New Delhi |
| kasturba Medical College | Mukhya Prabhu | India | NA | Manipal |
| Sterling Hospital | Dr. Navneet Shah | India | NA | Ahmedabad |
| Mediciti Hospital | Rakesh Sahay | India | NA | Hyderabad |
| Jehangir Hospital | Mohan Magdum | India | NA | Pune |
| Paras Hospital | R R Dutta | India | NA | Gurgaon |
| Vikram Hospital & Heart Care | Dr Keshava CB Murthy | India | NA | Karnataka |
| Belgaum Diabetes Centre | Dr Neeta Rohit Deshpande | India | NA | Belgaum |
| Meenakshi Mission Hospital And Research Centre | Dr Selvamani - Sethuraman | India | NA | Madurai |
| Indian Clinic | Noor Khan | India | NA | Bangalore |
| Diabetes care and research center Pvt Ltd | Sunil Kumar Gupta | India | NA | Nagpur |
| Niramay Hospital | Dr Abhijeet Bhaskar Joshi | India | NA | Pune |
| Sushrutha Multispeciality Hospital and Research Center | Narendra Hiregouder | India | NA | Hubli |
| Supe Heart & Diabetes Hospital & Research center | Dr Pravin Dinkar Supe | India | NA | Nasik |
| Srkalla Hospital | JUGAL BIHARI GUPTA | India | NA | Jaipur |
| Omega Hospital | Mukund Kumbla | India | NA | Mangalore |
| Magnum Heart Institute | Dr Manoj Chopda | India | NA | Nashik |
| Hospital San Martin | MD Victor Francisco COMMENDATORE | Argentina | NA | Parana |
| Consultorios Asoc. de Endocrinologia e Inv. Clin. Aplicada | MD Laura Elena MAFFEI | Argentina | NA | CABA |
| Instituto De Cardiología De Corrientes | MD Julio Andres VALLEJOS | Argentina | NA | Corrientes |
| CIPADI | MD Pedro Rosario Fabian CALELLA | Argentina | NA | Godoy Cruz |
| CORDIS Instituto del Corazon | MD Oscar Renzo CODUTTI | Argentina | NA | Resistencia |
| Investigaciones Clinicas Tucuman | MD Florencia WAISMAN | Argentina | NA | San Miguel De Tucuman |
| Investigaciones Medicas IMOBA SRL | MD Silvia Ines ORIO | Argentina | NA | Capital Federal |
| Clinica Privada Caraffa S.R.L./ IPAC | MD Hugo Roberto RAMOS | Argentina | NA | Cordoba |
| Instituto de Investigaciones Clinicas | MD Mariana LAGRUTTA | Argentina | NA | Rosario |
| Instituto Latinoamericano De Investigaciones Metabolicas | MD Maria Rosa ULLA | Argentina | NA | Cordoba |
| Cinme - Centro De Investigaciones Metabolicas | MD Federico Carlos PEREZ MANGHI | Argentina | NA | Capital Federal |
| Hospital Juan Ramon Vidal | MD Silvia Beatriz GORBAN DE LAPERTOSA | Argentina | NA | Corrientes |
| Centro Medico FAMYL | MD Miguel Hugo BUSTAMANTE LABARTA | Argentina | NA | Junin |
| Clinica Coronel Suarez | MD Alberto CACCAVO | Argentina | NA | Coronel Suarez |
| Instituto de Investigaciones Clinicas de Cordoba | MD Ines Palmira BARTOLACCI | Argentina | NA | Cordoba |
| Instituto de Investigaciones Clinicas Quilmes | MD Alberto Alfredo FERNANDEZ | Argentina | NA | Quilmes |
| Dim Clinica Privada | MD Oscar Romano MONTANA | Argentina | NA | Ramos Mejia |
| Instituto Cardiovascular de Rosario | MD Andres Domingo Oscar ORLANDINI | Argentina | NA | Rosario |
| Clinica Instituto Medico Adrogue | MD Pablo Omar SCHYGIEL | Argentina | NA | Adrogue |
| Instituto De Investigaciones Clinicas Zarate | MD Marisa Liliana VICO | Argentina | NA | Zarate |
| Hospital Regional Espanol Bahia Blanca | MD Cristian Aljandro PATOCCHI | Argentina | NA | Bahia Blanca |
| Instituto de Investigaciones Clínicas San Nicolas | MD Ruben Omar GARCIA DURAN | Argentina | NA | San Nicolas |
| Sanatorio San Martin SA | MD Oscar Alberto GOMEZ VILAMAJO | Argentina | NA | Venado Tuerto |
| Centro de Investigaciones Clinicas del litoral | MD Maria Cecilia CANTERO | Argentina | NA | Santa Fe |
| Instituto De Investigaciones Clinicas | MD Ignacio Jorge MACKINNON | Argentina | NA | Mar Del Plata |
| Clinica Del Prado | MD Lilia Beatriz SCHIAVI | Argentina | NA | Cordoba |
| Consultorio Integral De Atencion Al Diabetico | MD Sonia Griselda HERMIDA | Argentina | NA | Moron |
| Clinica De Fracturas Y Ortopedia | MD Andrés ALVARISQUETA | Argentina | NA | Mar Del Plata |
| Centro de Investigacion Medica Lanus (C.I.Me.L) | MD Claudia Emilce BACCARO | Argentina | NA | Lanus |
| Consultan Salud | MD Javier Claudio MARINO | Argentina | NA | Haedo |
| Instituto De Investigaciones Clinicas Bahia Blanca | MD Jose CUELLO | Argentina | NA | Bahia Blanca |
| Sanatorio Mayo SA | MD Alberto Jose LICHERI | Argentina | NA | Santa Fe |
| Instituto Villa Maria | MD Anselmo Paulino BORDONAVA | Argentina | NA | Villa Maria |
| Clinica Parra Centro de Investigaciones Clinicas de Rafaela | MD Osvaldo Jose Angel COSTAMAGNA | Argentina | NA | Rafaela |
| CENUDIAB | MD Alejandra OVIEDO | Argentina | NA | CABA |
| Clínica Radiologica del Sur | MD Pedro URDIALES | Argentina | NA | Cipolletti |
| Centro Modelo De Cardiologia | MD Hector Lucas LUCIARDI | Argentina | NA | San Miguel De Tucuman |
| Instituto Cardiovacular Buenos Aires | MD Marcelo TRIVI | Argentina | NA | Ciudad Autonoma De Bs.as |
| Hospital Italiano Regional Del Sur | MD Carlos Alejandro ALVAREZ | Argentina | NA | Bahia Blanca |
| Centro Cardiovascular Salta | MD Ricardo Alfonso LEON DE LA FUENTE | Argentina | NA | Salta |
| Centro Privado de Enfermedades Cardiovasculares | MD Florencia ROLANDI | Argentina | NA | CABA |
| Hospital Central Mendoza | MD Raquel Beatriz SAA ZARANDON | Argentina | NA | Mendoza |
| Sanatorio Santa Rosa | MD Leonardo Pedro NOVARETTO | Argentina | NA | Santa Rosa |
| IDYTAC - Instituto de Diagnostico y Tratamiento | MD Diego David GRINFELD | Argentina | NA | La Plata |
| Sanatorio Parque S.A. | MD Silvia Salome SAAVEDRA | Argentina | NA | Salta |
| Centro Medico Viamonte | MD Diego AIZENBERG | Argentina | NA | CABA |
| Hospital Sao Paulo | Antonio Roberto CHACRA | Brazil | NA | Sao Paulo |
| Clínica LOEMA | MD Fabio Rossi DOS SANTOS | Brazil | NA | Campinas |
| Centro de Estudos em Diabetes e Hipertensao Ltda | MD Adriana Costa E FORTI | Brazil | NA | Fortaleza |
| Hospital Universitario Walter Cantidio | DrMed MD Miguel Nasser HISSA | Brazil | NA | Fortaleza |
| Hospital das Clinicas de Sao Paulo | Alfredo HALPERN | Brazil | NA | Sao Paulo |
| CARDRESEARCH - Cardiologia Assistencial e de Pesquisa | DrMed MD Gilmar REIS | Brazil | NA | Belo Horizonte |
| Instituto Do Coracao Do Triangulo | DrMed Roberto Vieira BOTELHO | Brazil | NA | Uberlandia |
| Santa Casa De Porto Alegre | Milton Moyses GOLBERT | Brazil | NA | Porto Alegre |
| Instituto Dante Pazzanese De Cardiologia | DrMed MD Elizabete Silva Dos SANTOS | Brazil | NA | Sao Paulo |
| Santa Casa De Misericordia De Belo Horizonte | Maria Regina Calsolari Pereira De SOUZA | Brazil | NA | Belo Horizonte |
| Hospital Moinhos De Vento | Guilherme Alcides Flores Soares ROLLIN | Brazil | NA | Porto Alegre |
| Hospital das Clinicas - FAMEMA | MD Jose Augusto SGARBI | Brazil | NA | Marilia |
| Hospital Sao Vicente De Paulo | Hugo Roberto Kurtz LISBOA | Brazil | NA | Passo Fundo |
| Hospital Beneficencia Portuguesa | Roberto Abrao RADUAN | Brazil | NA | Sao Paulo |
| Instituto de Ensino e Pesquisa Clínica do Ceara Ltda. | Maria Jose Araujo Gomes CERQUEIRA | Brazil | NA | Fortaleza |
| Nucleo de Pesquisa Clinica S/S | PhD Paulo Roberto Ferreira ROSSI | Brazil | NA | Curitiba |
| Hospital Santa Izabel / Santa Casa de Misericordia da Bahia | MD Gilson Soares FEITOSA | Brazil | NA | Salvador |
| Instituto de Cardiologia do Distrito Federal | Juliana Ascencao De SOUZA | Brazil | NA | Brasilia |
| Centro de Cardiologia e Radiologia Intervencionista | MSc MD Max Weyler NERY | Brazil | NA | Goiana |
| Hospital De Clinicas Gaspar Vianna | PhD MD Fernando De Souza Flexa Ribeiro FILHO | Brazil | NA | Belem |
| Hospital Agamenon Magalhaes | Joao Batista De Moura Xavier DE MORAES JUNIOR | Brazil | NA | Recife |
| Instituto De Cardiologia Do Rio Grande Do Sul | Alexandre Schaan De QUADROS | Brazil | NA | Porto Alegre |
| Consultorio Dr. Yan Duarte | MD Yan Carlos DUARTE VERA | Ecuador | NA | Guayaquil |
| Consultorio Dr. Ricardo Marmol | MD Ricardo Patricio MARMOL ALVEAR | Ecuador | NA | Guayaquil |
| Hospital Luis Vernaza | MD Carlos Ernesto PENAHERRERA PATINO | Ecuador | NA | Guayaquil |
| Hospital Nacional Cayetano Heredia | MD Miguel E. PINTO | Peru | NA | Lima |
| CENTRO DE INVESTIGACIONES MEDICAS METABOLICARE SAC | MD Carlos Eugenio ZUBIATE LOPEZ | Peru | NA | Lima |
| Centro De Investigacion En Diabetes, Obesidad Y Nutricion | MD Helard Andres MANRIQUE HURTADO | Peru | NA | Lima |
| NOVOCARDIO CENTRO DE INVESTIGACION Y ATENCION CARDIOVASCULAR | MD Jorge Richard CALDERON TICONA | Peru | NA | Lima |
| Instituto Endocrinologico Farfan EIRL | MD Julio Cesar FARFAN ASPILCUETA | Peru | NA | Arequipa |
| Unidad Cardio-Metabolica | MD Jesus Mario CARRION CHAMBILLA | Peru | NA | Lima |
| Centro Investigacion Heart Help | MD Yudy Miluska ROLDAN CONCHA | Peru | NA | Lima |
| INCA (Instituto Neuro Cardiovascular de las Americas) | MD Walter MOGROVEJO | Peru | NA | Lima |
| INCOR | MD Manuel HORNA | Peru | NA | Lima |
| Instituto de Salud Cardiovascular | MD Carlos Antero CHAVEZ AYALA | Peru | NA | Callao |
| Instituto Cardiovascular de la Clinica Javier Prado | MD Libia Isabel LU GALARRETA | Peru | NA | Lima |
| Centro de Investigación en Cardiología | MD Roger Martin CORREA FLORES | Peru | NA | Lima |
| Clinica Internacional | MD Miguel Angel ANDRADE MONDONEDO | Peru | NA | Lima |
| Hospital Nacional Edgardo Rebagliati M Essalud | MD Marcos Lorenzo PARIONA JAVIER | Peru | NA | Lima |
| CI Metabolicas y Cardiologicas Clinica Castilla ESSALUD | MD Edith Jacqueline LUQUE | Peru | NA | Lima |
| Azienda Ospedaliero-Universitaria Pisana | Stefano Del Prato | Italy | NA | Pisa |
| Policlinico Colle dell'Ara | Medicina e Chirurgia Agostino Consoli | Italy | NA | Chieti |
| Ospedale Maggiore Di Chieri | MD carlo bruno giorda | Italy | NA | Chieti |
| A O Universitaria Policlinico P Giaccone | Carla Giordano | Italy | NA | Palermo |
| Ospedale Civile Augusto Murri | MD Sandra Di Marco | Italy | NA | Fermo |
| Ospedale La Colletta | paola ponzani | Italy | NA | Genova |
| Azienda Universitario Ospedaliera Policlinico Di Careggi | Edoardo Mannucci | Italy | NA | Firenze |
| Ospedale San Raffaele | MD PierMarco Piatti | Italy | NA | Milano |
| Azienda Ospedaliera San Paolo | DrMed Antonio ANTONIO Pontiroli | Italy | NA | Milano |
| Universita Campus Bio-Medico | Paolo Pozzilli | Italy | NA | Roma |
| Universita Degli Studi Di Napoli Federico II | Angela Rivellese | Italy | NA | Napoli |
| Azienda Ospedaliera Universitaria Policlinico G. Martino | MD Domenico Cucinotta | Italy | NA | Messina |
| Azienda Ospedaliera Maggiore Della Carita | Gianluca Aimaretti | Italy | NA | Novara |
| Istituto Clinico Humanitas | MD Cesare Berra | Italy | NA | Rozzano |
| Ospedale Maggiore Policlinico | DrMed Emanuela Orsi | Italy | NA | Milano |
| Carpi - USL di Modena | MPH,MD Anna Vittoria Ciardullo | Italy | NA | Carpi |
| Istanbul University Medical Faculty Clinic of Endocrinology | nevin dinccag | Turkey | NA | Istanbul |
| Baskent University Medical Faculty Department of Endocrinology | neslihan bascil tutuncu | Turkey | NA | Ankara |
| Ege University Medical Faculty Department of Cardiology | Hakan Kultursay | Turkey | NA | Izmir |
| SB Ankara Diskapi Yildirim Beyazit Training and Research Hospital | DrMed tuncay delibasi | Turkey | NA | Ankara |
| Ege University Medical Faculty Department Internal Medicine | Fusun Saygili | Turkey | NA | Izmir |
| Istanbul University Cardiology Enstitution | zerrin yigit | Turkey | NA | Istanbul |
| Mersin University School of Medicine department of Cardiology | ahmet camsari | Turkey | NA | Mersin |
| Hacettepe University School of Medicine Deaprtment of Cardiology | BS ALI OTO | Turkey | NA | Ankara |
| 19 Mayis University School of Medicine Department of Cardiology | Med MD PMP Mahmut Sahin | Turkey | NA | Samsun |
| MALTEPE UNIVERSITESI iC HASTALIKLARI | GULBUZ Guler SEZGIN | Turkey | NA | Istanbul |
| YEDIKULE GOGUS HASTALIKLARI HASTANESI | PhD MD Cafer Sadik Zorkun | Turkey | NA | Istanbul |
| Santo Tomas University Hospital | DrMed Maria Honolina Sero GOMEZ | Philippines | NA | Manila |
| San Juan De Dios Hospital | DrMed,MD Cecilia Jimeno | Philippines | NA | Pasay City |
| Ospital NG Makati | DrMed Rosa Allyn Gajo Sy | Philippines | NA | Makati City |
| Amang Rodriguez Medical Center | MD Araceli PANELO | Philippines | NA | Marikina City |
| De La Salle University Medical Centre | NANNETTE REY | Philippines | NA | Cavite |
| Philippine General Hospital | BS,DrMed,MS Antonio Dans | Philippines | NA | Manila |
| Quirino Memorial Medical Center | Dennis Jose Villareal Sulit | Philippines | NA | Quezon City |
| Adventist Medical Center | DrMed Miriam Roxas Timonera | Philippines | NA | Iligan City |
| Private Clinic of Dr. Ellen Palomares | Ellen Palomares | Philippines | NA | Laoag City |
| Taipei Veterans General Hospital | Chern-En Chiang | 中国 | 台湾 | Taipei |
| National Taiwan University Hospital | Tzung-Dau Wang | 中国 | 台湾 | Taipei |
| Cardinal Tien Hospital | DEE PEI | 中国 | 台湾 | New Taipei |
| Chung-Shan Medical University Hospital | Kwo-Chang Ueng | 中国 | 台湾 | Taichung |
| Chia-Yi Christian Hospital | Chieh-Hsiang Lu | 中国 | 台湾 | Chia-Yi |
| Chi-Mei Medical Center | Tsuei-Yuan Huang | 中国 | 台湾 | Tainan |
| Shin Kong Memorial Hospital | Kou-Gi Shyu | 中国 | 台湾 | Taipei |
| Far East Memorial Hospital | Yu-Wei Chiu | 中国 | 台湾 | New Taipei |
| Sheikh Khalifa Medical City | Dr. Wael Al MAHMEED | United ARAB EMIRATES | NA | Abu Dhabi |
| Rashid Hospital | Dr. Zufana Nazir | United ARAB EMIRATES | NA | Dubai |
| Creighton University Medical Center | MD Marc Rendell | United States | NA | Omaha |
| Kansas City VAMC | MD Virginia Savin | United States | NA | Kansas City |
| Cotton-O'Neill Clinical Research Center | Alan Wynne | United States | NA | Topeka |
| James Thrasher, PC | MD James Thrasher | United States | NA | Little Rock |
| The Carl and Edyth Lindner Center for Research and Education | Dean KEREIAKES | United States | NA | Cincinnati |
| Tucson VAMC | MD Stephen THOMSON | United States | NA | Tucson |
| Cardiac Consultants, LLC | James Welker | United States | NA | Annapolis |
| Washington DC VAMC | Vasilios Papademetriou | United States | NA | Washington |
| Advance Clinical Research, Inc | MD Brij Vaid | United States | NA | St. Louis |
| Stern Cardiovascular Foundation | DrMed Frank Augustus McGrew | United States | NA | Germantown |
| The Heart and Vascular Institute of Florida | DrMed,FACMI Jeffrey STEINHOFF | United States | NA | St. Petersburg |
| Internal Medicine Northwest | Sabrina Benjamin | United States | NA | Tacoma |
| NJ Heart - UNJ Hospital | MD PREET RANDHAWA | United States | NA | Linden |
| Rowan Research Inc | Leroy Byrd | United States | NA | Spokane |
| Meharry Medical Center | BS,PhD,MD john murray | United States | NA | Nashville |
| Gunderson-Lutheran Medical Center | Mary Frohnauer | United States | NA | Lacrosse |
| Intracoastal Family Practice | Edward HANNA | United States | NA | Chesapeake |
| West Los Angeles VAMC | MD Alberta L Warner | United States | NA | Los Angeles |
| Bala and Khaira Medical Research Center | DrMed Ajit khaira | United States | NA | Fresno |
| Heart and Vascular Center of New Brunswick | MD Dinesh SINGAL | United States | NA | Somerset |
| Grace Research | Shaun Kelehan | United States | NA | Marshall |
| Louisiana State University | DrMed Steven LEVINE | United States | NA | Shreveport |
| Cardiovascular Associates, LTD | DrMed,FACP Ramin Alimard | United States | NA | Chesapeake |
| NEA Baptist Clinic | Anthony WHITE | United States | NA | Jonesboro |
| The Center for Clinical Trials | MD magdy mikhail | United States | NA | Biloxi |
| Harris and Associates | DrMed Anthony Frank HARRIS | United States | NA | Detroit |
| Alliance Clinical Research | Michael MORAN | United States | NA | Vista |
| Center for Clinical Trials | Gamil Dawood | United States | NA | Mobile |
| Hines VAMC | Nasrin Azad | United States | NA | Hines |
| York Clinical Research, Inc. | FACP,MD Charles Lovell | United States | NA | Norfolk |
| Palm Research Center | MD Samer NAKHLE | United States | NA | Las Vegas |
| Loma Linda VAMC | Ronald Fernando | United States | NA | Loma Linda |
| Carolina Health Specialists | DrMed Donald EAGERTON | United States | NA | Myrtle Beach |
| Providence VAMC | Wen-Chih Wu | United States | NA | Providence |
| Northridge Hospital Medical Center | DrMed Mehrdad kevin ARIANI | United States | NA | Northridge |
| Florida Research Testing | Ali SAIFI | United States | NA | Clearwater |
| The Endocrine Group | Mark Yocono | United States | NA | Albany |
| Roanoke Heart Institute, PLC | MD John F Schmedtje | United States | NA | Roanoke |
| MODEL Clinical Research | DrMed Philip Levin | United States | NA | Towson |
| Cardiology Clinical Research Center | MD Jean Foucauld | United States | NA | Wellington |
| G & L Research LLC | DrMed Nidal MORRAR | United States | NA | Foley |
| Charm Research/ Diagnostic Center | MD Eugene Healy Ryan | United States | NA | Chattanooga |
| Charles George VA Medical Center | MD ChoYen CHIOU | United States | NA | Asheville |
| KORE Cardiovascular Research | elie korban | United States | NA | Jackson |
| Merced Heart Associates | Mani NALLASIVAN | United States | NA | Merced |
| Anasazi Internal Medicine | Richard Kelly | United States | NA | Phoenix |
| Helping Hands Medical Associates, Inc. | DrMed Alan Charles Schwartz | United States | NA | Santa Ana |
| Northwest Endocrinology | DrMed jose de Souza | United States | NA | Kalispell |
| Eastern Carolina Cardiovascular Associates | DrMed Lindsey WHITE | United States | NA | Elizabeth City |
| Provena Saint Joseph Medical Center | MD Stavros Maragos | United States | NA | Joliet |
| Saviers Medical Group | MD Eugene Soroka | United States | NA | Port Hueneme |
| American Institute of Research | MD Clayton McDaniel | United States | NA | Whittier |
| St Joseph Hospital | Francis RHIE | United States | NA | Orange |
| Northern Pines Health Center | DO Mitzie Hewitt | United States | NA | Buckley |
| Cardiology and Medicine Clinic | MD Joe Hargrove | United States | NA | Little Rock |
| RAS Health, LTD | Chander Arora | United States | NA | Marion |
| Wilmington Medical Research | MD Brian Webster | United States | NA | Wilmington |
| University of Nevada School of Medicine | PhD,MD David Howard | United States | NA | Reno |
| Texas Tech University | C W Spellman | United States | NA | Lubbock |
| Vanderbilt University | michael may | United States | NA | Nashville |
| St John's Mercy Medical Center | Anthony Sonn | United States | NA | St. Louis |
| Preferred Primary Care Physicians | DrMed Bryce Palchick | United States | NA | Pittsburgh |
| Borgess Research Institute | MD Craig Greenberg | United States | NA | Kalamazoo |
| Alzohaili Medical Consultants | Opada Alzohaili | United States | NA | Dearborn |
| Idaho State University | RPh Eliza Zofia Borzadek | United States | NA | Pocatello |
| Oregon Health and Sciences University | DrMed Farahnaz Joarder | United States | NA | Portland |
| Endocrinology Services Northwest | MD Travis Monchamp | United States | NA | Bend |
| Michael Dempsey, PC | DrMed michael A dempsey | United States | NA | Rockville |
| Metabolic Clinic and Research Center | MD Salman Khan | United States | NA | Los Angeles |
| Compass Research East, LLC | Bradley Block | United States | NA | Oviedo |
| Emory University | Guillermo E Umpierrez | United States | NA | Atlanta |
| in-Quest Medical Research, LLC | DrMed Naresh Parikh | United States | NA | Duluth |
| Pikeville Medical Center | MD Bill Herbert Harris | United States | NA | Pikeville |
| Virginia Endocrinology Research | DrMed James LaRocque | United States | NA | Chesapeake |
| Sutter Institute for Medical Research | DrMed Francisco Prieto | United States | NA | Roseville |
| Focus Clinical Trials | MD Joseph F Kasper | United States | NA | Draper |
| Baylor University | MD Cara East | United States | NA | Dallas |
| PMG Research of Raleigh | John Rubino | United States | NA | Raleigh |
| Emory University | ARSHED QUYYUMI | United States | NA | Atlanta |
| St. Mary's Hospital | DrMed James Mathew | United States | NA | Milwaukee |
| United Clinical Research Center | Samir Azzam | United States | NA | Anaheim |
| University of Virginia | DrMed Anthony McCall | United States | NA | Charlottesville |
| Phoenix VA Heath Care System | DrMed Charles C Oh | United States | NA | Phoenix |
| Kaiser Permanente | DrMed Charles Robert Elder | United States | NA | Portland |
| PhysiqueMed Clinical Trials | DrMed Robyn Sanders | United States | NA | Greensboro |
| Northwest Heart Clinical Research | Steven Lupovitch | United States | NA | Arlington Heights |
| North Phoenix Heart Center | MD warren breisblatt | United States | NA | Phoenix |
| AM Diabetes and Endrocrinology Center | Kashif Latif | United States | NA | Bartlett |
| Green Ville Hospital System | DrMed Sandra Weber | United States | NA | Green Ville |
| Texas Tech University | Tamis Bright | United States | NA | Lubbock |
| DCOL Center for Clinical Research | Kathleen Weindorff | United States | NA | Longview |
| Mountain View Clinical Research Inc | DrMed Ronald Keith Mayfield | United States | NA | Greer |
| Black Hills Cardio Research | MD Alex Schabauer | United States | NA | Rapid City |
| Clinical Research Institute of Michigan | MD Kenneth Smith | United States | NA | Chesterfield |
| Primary Care Associates | MD Michael Trotta | United States | NA | Butler |
| Houston Cardiovascular Associates | MD Subroto Gangopadhyay | United States | NA | Sugarland |
| Pulmonary and Hospitalist Associates | asif mahmood | United States | NA | San Marino |
| Alta California Medical Group | DrMed Alberto Odio | United States | NA | Simi Valley |
| Indus Clinical Research Institute | MD Yogesh Paliwal | United States | NA | Pomona |
| Queens Hospital Center Department Psychiatry T-3a-19 | DrMed isaac sachmechi | United States | NA | Jamaica |
| Precision Research Institute | Jerome Robinson | United States | NA | National City |
| Consultant Associates | MD Paul Alappat | United States | NA | Fairmount |
| Huntington Medical Group | DrMed John C Mathew | United States | NA | Huntington |
| Sarah Olelewe, PC | MD sarah sam Olelewe | United States | NA | Hawthorne |
| The Valley Hospital | Marcus WILLIAMS | United States | NA | Ridgewood |
| Thomas L. Pitts, PC | DrMed Thomas Pitts | United States | NA | Chicago |
| Chrishard Medical Group | MD Cranford Scott | United States | NA | Inglewood |
| University of Tennessee | PhD,MD Aidar Gosmanov | United States | NA | Memphis |
| Clinical Outcome Improvement Medicine, LLC | DrMed,MD Charles Moore II | United States | NA | Catonsville |
| Southern Piedmont Primary Care Novant Heart and Wellness - P | DrMed Jacques Laguerre | United States | NA | Monroe |
| H Watson, PC | MD Henry Geoffrey Watson | United States | NA | Oakland |
| Cardiovascular Associates of Mesa | DrMed suzanne sorof | United States | NA | Mesa |
| John H. Stroger, Jr. Hospital | MD Leon Fogelfeld | United States | NA | Chicago |
| Rancho Los Amigos Hospital | MD Sylvia Shaw | United States | NA | Downey |
| Hammond Heart Center | Ghiath Mikdadi | United States | NA | Hammond |
| Heartbright Foundation Cardiac Resources Clinic | DrMed,MD James Wayne Roberts | United States | NA | Charlotte |
| Saint Louis Heart and Vascular | DrMed Mohammad Tahir | United States | NA | St. Louis |
| UnityPoint Health Methodist/Proctor Diabetes Care Center | MD David Trachtenbarg | United States | NA | Peoria |
| Ivy Madu, PC | MD Ivy-joan Madu | United States | NA | Orange |
| IMC / Diagnostic And Medical Clinic | Frank Martin Lester | United States | NA | Mobile |
| UCLA | DrMed William J French | United States | NA | Los Angeles |
| Cardiology Consultants of Orange County | Harinder Gogia | United States | NA | Anaheim |
| Clínica Tabancura | MD PABLO ANDRES SEPULVEDA | Chile | NA | Santiago |
| Consulta Privada | Carmen Lia Lia Solis | Chile | NA | Santiago |
| Consulta Privada | Gonzalo Godoy | Chile | NA | Santiago |
| Hospital Naval Almirante Nef | Mario Yanez | Chile | NA | Vina Del Mar |
| Biomed LTDA | MD Gladys Larenas | Chile | NA | Temuco |
| Centro de Estudios Clinicos e Investigaciones Medicas S&P | Victor SAAVEDRA | Chile | NA | Santiago |
| Centro Clinico y Metabolico | MD ELIANA REYES | Chile | NA | Santiago |
| Centro de Estudios Clinicos Quinta Region | Carlos Antonio Raffo | Chile | NA | Vina Del Mar |
| Hospital Barros Luco Trudeau | Marcelo Medina | Chile | NA | Santiago |
| Centro De Estudios Cardiovasculares | DrMed Fernando tomas Lanas | Chile | NA | Temuco |
| Hospital y CRS El Pino | Juan Carlos PALMA | Chile | NA | Santiago |
| CENTRO DE INVESTIGACION CLINICA | DrMed Rodolfo Lahsen | Chile | NA | Santiago |
| Consulta Privada | Carmen Solis | Chile | NA | Santiago |
| Hospital Clinico Universidad De Chile | DrMed GASTON DUSSAILLANT | Chile | NA | Santiago |
| Hospital Regional De Concepcion | DrMed LUIS PEREZ | Chile | NA | Concepcion |
| Hospital Regional De Antofagasta | Bernhard Westerberg | Chile | NA | Antofagasta |
| Clinica UCM | PhD Laura Andrea Huidobro | Chile | NA | Talca |
| Centro de estudios clinicos Santiago Oriente | Patricio Sanhueza | Chile | NA | Santiago |
| Hospital Universidad Catolica | Ramon Corbalan | Chile | NA | Santiago |
| Consulta Privada | Leonardo COBOS | Chile | NA | Santiago |
| Hospital Carlos Van Buren | DrMed SILVIA ACUNA | Chile | NA | Valparaiso |
| Biomedica Research Group | MD Fernando Florenzano | Chile | NA | Santiago |
| Centro Luis Pasteur | MD Leopoldo Manriquez | Chile | NA | Rancagua |
| HOSPITAL SAN CAMILO | Lia Bunster | Chile | NA | SAN Felipe |
| Hospital Regional Valdivia | MD German Eggers | Chile | NA | Valdivia |
| hospital clinico de Magallanes | PhD MD Guillermo A Araneda | Chile | NA | Punta arenas |
| hospital base de puerto montt | MD CLAUDIA ALEJANDRA TORRES | Chile | NA | Puerto montt |
| Corporacion de Beneficencia Osorno | SERGIO POTTHOFF | Chile | NA | Osorno |
| Hospital Clinico San Borja Arriaran | Nestor SOTO | Chile | NA | Santiago |
| Centre De Recherche Clinique De Laval | MD Richard DUMAS | Canada | NA | Laval |
| Centre de Sante et de Services Sociaux de la region Thetford | DrMed Jean CAMPEAU | Canada | NA | Thetford Mines |
| Centre Medical des Carrieres | Pierre FILTEAU | Canada | NA | St-Marc-des-Carrieres |
| Research Office | Gurcharan SYAN | Canada | NA | Sudbury |
| Applied Medical Informatics Research Inc. (A.M.I.R) | FRCPC George TSOUKAS | Canada | NA | Westmount |
| Research Office | Rajinder SYAN | Canada | NA | Sarnia |
| Institut De Cardiologie De Montreal | DrMed Jean-Claude TARDIF | Canada | NA | Montreal |
| Heritage Medical Research Clinic | DrMed James Wayne WARNICA | Canada | NA | Calgary |
| Institut universitaire de cardiologie et de pneumologie | MD Olivier BERTRAND | Canada | NA | Quebec |
| Heart Care Research | FRCPC,MD Rakesh BHARGAVA | Canada | NA | Oshawa |
| The Bailey Clinic | MD Gordon BAILEY | Canada | NA | Red Deer |
伦理委员会信息
| 名称 | 审查结论 | 审查日期 |
|---|---|---|
| 中国人民解放军总医院医学伦理委员会 | 同意 | 2012-10-30 |
试验状态信息
试验状态
已完成
目标入组人数
国内: 300 人；
国际: 6000 人；
已入组例数
国内: 登记人暂未填写该信息；
国际: 登记人暂未填写该信息；
实际入组总例数
国内: 113 人 ；
国际: 6072 人；
第一例受试者签署知情同意书日期
国内：登记人暂未填写该信息；
国际：登记人暂未填写该信息；
第一例受试者入组日期
国内：2013-01-07；
国际：2010-06-24；
试验终止日期
国内：2014-12-22；
国际：登记人暂未填写该信息；
临床试验结果摘要
| 版本号 | 版本日期 |
|---|
