登记号
CTR20131447
相关登记号
曾用名
药物类型
化学药物
临床申请受理号
企业选择不公示
适应症
肾细胞癌辅助治疗
试验通俗题目
培唑帕尼辅助治疗对术后肾细胞癌的有效性和安全性研究
试验专业题目
随机、双盲、安慰剂对照、III期研究评价培唑帕尼辅助治疗肾切除术后的局限期肾癌患者的有效性和安全性
试验方案编号
CPZP034D2301
方案最近版本号
V06
版本日期
2016-04-25
方案是否为联合用药
企业选择不公示
申请人信息
申请人名称
联系人姓名
诺华肿瘤医学热线
联系人座机
400-8180600
联系人手机号
联系人Email
china.obumi@novartis.com
联系人邮政地址
北京市-北京市-朝阳区针织路23号楼5层
联系人邮编
100004
临床试验信息
试验分类
安全性和有效性
试验分期
III期
试验目的
评价培唑帕尼作为辅助治疗对肾切除术后局限性或局部进展性肾细胞癌患者的有效性和安全性。
随机化
随机化
盲法
双盲
试验范围
国际多中心试验
设计类型
平行分组
年龄
18岁(最小年龄)至
无岁(最大年龄)
性别
男+女
健康受试者
无
入选标准
- 诊断为肾细胞癌，组织学为透明细胞或以透明细胞为主型。
- 符合基线期无病状态的标准。
- 器官系统功能良好
- 非转移性疾病（M0）受试者,符合综合2010年版AJCC 病理TNM分期标准和Fuhrman核分级之一：1）pT2，G3或G4，N0；或者 2）pT3，Gany，N0；或者 3）pT4，Gany，N0：或者 4）pTany，Gany，N1
- 过去未接受过针对RCC的辅助治疗或新辅助治疗。
排除标准
- 局部复发RCC、双侧RCC或其它恶性肿瘤病史
- 慢性活动性肝炎的病史，包括乙肝病毒（HBV）或丙肝病毒（HCV）携带者
- 人类免疫缺陷病毒（HIV）感染病史
- 具有临床意义的、可能会增加胃肠道出血风险的胃肠道异常
试验分组
试验药
| 名称 | 用法 |
|---|---|
|
中文通用名:培唑帕尼
|
用法用量:片剂；规格200mg；口服，每天一次，起始剂量每次 600mg， 用药时程，连续用药，共计8到12周；然后根据受试者的安全性和耐受性，由研究者根据方案规定决定是否增加到800mg剂量水平或者保持600mg剂量水平。治疗总时程为12个月。
|
对照药
| 名称 | 用法 |
|---|---|
|
中文通用名:安慰剂
|
用法用量:片剂；规格200mg；口服，每天一次，起始剂量每次 600mg， 用药时程，连续用药，共计8到12周；然后根据受试者的安全性和耐受性，由研究者根据方案规定决定是否增加到800mg剂量水平或者保持600mg剂量水平。治疗总时程为12个月。
|
终点指标
主要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 无病生存期（DFS） | 当获得578个DFS事件时进行评价。 | 有效性指标 |
次要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 总生存期（OS） | 当获得578个DFS事件时进行评价。 | 有效性指标 |
| 生活质量 | 当获得578个DFS事件时进行评价。 | 有效性指标+安全性指标 |
| 安全性和耐受性 | 当获得578个DFS事件时进行评价。 | 安全性指标 |
| 年DFS率（如1年、2年等） | 当获得578个DFS事件时进行评价。 | 有效性指标 |
数据安全监察委员会（DMC）
有
为受试者购买试验伤害保险
有
研究者信息
| 姓名 | 学位 | 职称 | 电话 | 邮政地址 | 邮编 | 单位名称 | |
|---|---|---|---|---|---|---|---|
| 叶定伟 | 医学博士 | 主任医师 | 021-64438650 | dwye@shca.org.cn | 上海市-上海市-徐汇区东安路270号 | 200032 | 复旦大学附属肿瘤医院 |
各参加机构信息
| 机构名称 | （主要）研究者 | 国家 | 地区 | 城市 |
|---|---|---|---|---|
| 复旦大学附属肿瘤医院 | 叶定伟 | 中国 | 上海市 | 上海市 |
| 中国医学科学院肿瘤医院 | 王金万 | 中国 | 北京 | 北京 |
| 上海交通大学医学院附属仁济医院 | 黄翼然 | 中国 | 上海 | 上海 |
| 天津肿瘤医院 | 姚欣 | 中国 | 天津 | 天津 |
| 北京大学第三医院 | 马潞林 | 中国 | 北京 | 北京 |
| 浙江大学医学院附属第一医院 | 谢立平 | 中国 | 浙江 | 杭州 |
| 复旦大学附属华山医院 | 丁强 | 中国 | 上海 | 上海 |
| 浙江大学医学院附属第二医院 | 杜传军 | 中国 | 浙江 | 杭州 |
| 上海瑞金医院 | 沈周俊 | 中国 | 上海 | 上海 |
| 华中科技大学同济医学院附属同济医院 | 叶章群 | 中国 | 湖北 | 武汉 |
| 复旦大学附属肿瘤医院 | 叶定伟 | 中国 | 上海 | 上海 |
| COIBA Centro de oncología e investig-Berazategui | Novartis' Investigator | Argentina | Buenos Aires | Berazategui |
| Instituto Alexander Fleming-Capital Federal | Novartis' Investigator | Argentina | Buenos Aires | Capital Federal |
| Hospital Alemán-Ciudad de Buenos Aires | Novartis' Investigator | Argentina | Buenos Aires | Ciudad de Buenos Aires |
| Instituto de Investigaciones Clinicas Cipolletti-Cipolletti | Novartis' Investigator | Argentina | Río Negro | Cipolletti |
| CER Instituto Medico-Quilmes | Novartis' Investigator | Argentina | Quilmes | Quilmes |
| Instituto Oncologico de Cordoba-Cordoba | Novartis' Investigator | Argentina | Córdova | Córdoba |
| Instituto Médico Especializado-Ciudad de Buenos Aires | Novartis' Investigator | Argentina | Buenos Aires | Ciudad de Buenos Aires |
| Centro Oncologico de Rosario-Rosario | Novartis' Investigator | Argentina | Santa Fe | Rosario |
| CEMIC-Ciudad Autonoma de Bueno | Novartis' Investigator | Argentina | Buenos Aires | Ciudad Autonoma de Bueno |
| Hospital Britanico de Buenos Aires-Ciudad Autónoma de Bueno | Novartis' Investigator | Argentina | Buenos Aires | Ciudad Autonoma de Buenos Aires |
| Fundacion RUSCULLEDA-Córdoba | Novartis' Investigator | Argentina | Córdova | Córdoba |
| ISIS Clinica Especializada-Santa Fe | Novartis' Investigator | Argentina | Santa Fe | Santa Fe |
| Sanatorio de la Providencia-Ciudad Autonoma de Bueno | Novartis' Investigator | Argentina | Buenos Aires | Ciudad Autónoma de Buenos Aires |
| Investigaciones Clinicas Ciudad Autonoma de Buenos-Buenos Aires | Novartis' Investigator | Argentina | Buenos Aires | Ciudad Autónoma de Buenos Aires |
| Centro Medico San Roque-San Miguel de Tucuman | Novartis' Investigator | Argentina | San Miguel de Tucumán | San Miguel de Tucumán |
| Universitaetsklinik Innsbruck-Innsbruck | Novartis' Investigator | Austria | Innsbruck | Innsbruck |
| LKH Salzburg-Salzburg | Novartis' Investigator | Austria | Salzburg | Salzburg |
| LKH Salzburg-Salzburg | Novartis' Investigator | Austria | Salzburg | Salzburg |
| AKH Wien-Vienna | Novartis' Investigator | Austria | Vienna | Vienna |
| LKH Graz-Graz | Novartis' Investigator | Austria | Graz | Graz |
| KH Hietzing mit Neurolog. Zentrum Rosenhügel-Vienna | Novartis' Investigator | Austria | Vienna | Vienna |
| Centre Hospitalier Universitaire de Liège-Liege | Novartis' Investigator | Belgium | Liège | Liège |
| Clinique St Elisabeth-Namur | Novartis' Investigator | Belgium | Namur | Namur |
| AZ St Augustinus-Wilrijk | Novartis' Investigator | Belgium | Wilrijk | Wilrijk |
| UZ Brussel-Brussel | Novartis' Investigator | Belgium | Jette | Jette |
| Heilig Hart Ziekenhuis 3-Roeselare | Novartis' Investigator | Belgium | Roeselare | Roeselare |
| JESSA Ziekenhuis Campus Virga Jesse-Hasselt | Novartis' Investigator | Belgium | Hasselt | Hasselt |
| Hospital Erasto Gaertner-Curitiba | Novartis' Investigator | Brazil | Paraná | Curitiba |
| Hospital Israelita Albert Einstein-Sao Paulo | Novartis' Investigator | Brazil | Sao Paulo | Sao Paulo |
| Hospital das Clínicas da Universidade Federal-Belo Horizonte | Novartis' Investigator | Brazil | Minas Gerais | Belo Horizonte |
| Instituto Nacional do Cancer - INCA-Rio de Janeiro | Novartis' Investigator | Brazil | Rio De Janeiro | Rio de Janeiro |
| Hospital Sirio Libanes-Sao Paulo | Novartis' Investigator | Brazil | Sao Paulo | Sao Paulo |
| Universidade Estadual de Campinas (UNICAMP)-Campinas | Novartis' Investigator | Brazil | Sao Paulo | Campinas |
| Hospital Universitário Pedro Ernesto-UERJ-Rio de Janeiro | Novartis' Investigator | Brazil | Rio De Janeiro | Rio De Janeiro |
| Instituto do Cancer do Estado de Sao Paulo-Sao Paulo | Novartis' Investigator | Brazil | Sao Paulo | Sao Paulo |
| Fundacao PIO XII - Hospital de Cancer de Barretos-Barretos | Novartis' Investigator | Brazil | Sao Paulo | Barretos |
| Clinica de Oncologia Medica-Sao Paulo | Novartis' Investigator | Brazil | Sao Paulo | Sao Paulo |
| Hospital de Caridade de Ijui-Ijui | Novartis' Investigator | Brazil | Rio Grande Do Sul | Ijui |
| Hospital santa marcelina-Sao Paulo | Novartis' Investigator | Brazil | Sao Paulo | Sao Paulo |
| PUC-RS/Hospital Sao Lucas-Porto Alegre | Novartis' Investigator | Brazil | Rio Grande Do Sul | Porto Alegre |
| Cross Cancer Institute-Edmonton | Novartis' Investigator | Canada | Alberta | Edmonton |
| Tom Baker Cancer Centre-Calgary | Novartis' Investigator | Canada | Alberta | Calgary |
| London Health Sciences Centre- Lawson Health-London | Novartis' Investigator | Canada | Ontario | London |
| Ottawa Regional Cancer Centre-Ottawa | Novartis' Investigator | Canada | Ontario | Ottawa |
| Lakeridge Health-Oshawa | Novartis' Investigator | Canada | Ontario | Oshawa |
| Princess Margaret Hospital-Toronto | Novartis' Investigator | Canada | Ontario | Toronto |
| CHUQ-Hotel Dieu de Quebec-Quebec | Novartis' Investigator | Canada | Québec | Québec |
| The Moncton Hospital-Moncton | Novartis' Investigator | Canada | New Brunswick | Moncton |
| Queen Elizabeth II Health Sciences Centre 2-Halifax | Novartis' Investigator | Canada | Nova Scotia | Halifax |
| Juravinski Cancer Centre-Hamilton | Novartis' Investigator | Canada | Ontario | Hamilton |
| CHUM Hopital Notre Dame-Quebec | Novartis' Investigator | Canada | Québec | Montreal |
| Vancouver Prostate Centre-Vancouver | Novartis' Investigator | Canada | British Columbia | Vancouver |
| Sunnybrook Health Sciences Centre-Toronto | Novartis' Investigator | Canada | Ontario | Toronto |
| Fundación Arturo López Pérez-Santiago-Chile-C | Novartis' Investigator | Chile | Región Metro De Santiago | Santiago |
| Instituto Oncologico-Vina del Mar-Chile-C | Novartis' Investigator | Chile | Valparaíso | Vina del Mar |
| Masarykova nemocnice-Usti nad Labem-Czech Republic-C | Novartis' Investigator | Czech Republic | Usti nad Labem | Usti nad Labem |
| VFN Praha 2-Praha 2-Czech Republic-C | Novartis' Investigator | Czech Republic | Praha 2 | Praha 2 |
| Nemocnice Na Bulovce-Praha 8-Czech Republic-C | Novartis' Investigator | Czech Republic | Praha 8 | Praha 8 |
| FNsP u sv. Anny-Brno-Czech Republic-C | Novartis' Investigator | Czech Republic | Brno | Brno |
| FN Plzen 2-Plzen-Czech Republic-C | Novartis' Investigator | Czech Republic | Plzen | Plzen |
| FN Hradec Kralove 5-Hradec Kralove-Czech Republic-C | Novartis' Investigator | Czech Republic | Hradec Kralove | Hradec Kralove |
| FN Olomouc-Olomouc-Czech Republic-C | Novartis' Investigator | Czech Republic | Olomouc | Olomouc |
| FNsP Ostrava- Poruba-Ostrava - Poruba-Czech Republic-C | Novartis' Investigator | Czech Republic | Ostrava - Poruba | Ostrava - Poruba |
| Masarykuv onkologicky ustav-Brno-Czech Republic-C | Novartis' Investigator | Czech Republic | Brno | Brno |
| Nemocnice Novy Jicin-Novy Jicin-Czech Republic-C | Novartis' Investigator | Czech Republic | Novy Jicin | Novy Jicin |
| Herlev Hospital-Herlev-Denmark-C | Novartis' Investigator | Denmark | Herlev | Herlev |
| Aarhus Universitetshospital, Aarhus Sygehus-Aarhus-Denmark-C | Novartis' Investigator | Denmark | Aarhus | Aarhus |
| Odense Universitetshospital-Odense C-Denmark-C | Novartis' Investigator | Denmark | Odense C | Odense C |
| Centre Francois Baclesse-Caen cedex 5-France-C | Novartis' Investigator | France | Caen Cedex 05 | Caen Cedex 05 |
| Institut Mutualiste Montsouris-Paris-France-C | Novartis' Investigator | France | Paris | Paris |
| Centre Eugène Marquis-Rennes-France-C | Novartis' Investigator | France | Rennes | Rennes |
| CHU de Poitiers - Hopital de la Milétrie-Poitiers cedex-France-C | Novartis' Investigator | France | Poitiers Cedex | Poitiers Cedex |
| HUS - Nouvel Hopital Civil-Strasbourg cedex-France-C | Novartis' Investigator | France | Strasbourg Cedex | Strasbourg Cedex |
| Institut de Cancérologie Paul Papin-Angers cedex 9-France-C | Novartis' Investigator | France | Angers cedex 9 | Angers cedex 9 |
| Institut Cancérologie de l’Ouest - René Gauducheau-Saint-Herblain cedex-France-C | Novartis' Investigator | France | Saint Herblain | Saint Herblain |
| Hopital Européen Georges Pompidou-Paris cedex 15-France-C | Novartis' Investigator | France | Paris Cedex 15 | Paris Cedex 15 |
| Polyclinique Courlancy-Reims-France-C | Novartis' Investigator | France | Reims | Reims |
| CHRU de Tours - Hopital Bretonneau-Tours cedex 9-France-C | Novartis' Investigator | France | Tours Cedex 9 | Tours Cedex 9 |
| Clinique Sainte Marguerite-Hyeres-France-C | Novartis' Investigator | France | Hyeres | Hyeres |
| CHU de Montpellier - Hopital Saint-Eloi-Montpellier cedex 5-France-C | Novartis' Investigator | France | Montpellier Cedex 5 | Montpellier Cedex 5 |
| CHU de Bordeaux - Hopital Saint André-Bordeaux-France-C | Novartis' Investigator | France | Bordeaux | Bordeaux |
| Centre Léon Bérard-Lyon cedex 08-France-C | Novartis' Investigator | France | Lyon Cedex 08 | Lyon Cedex 08 |
| CHU de Marseille - Hopital de la Timone-Marseille cedex 5-France-C | Novartis' Investigator | France | Marseille cedex 5 | Marseille cedex 5 |
| CHU de Besancon - Hopital Jean Minjoz-Besancon cedex-France-C | Novartis' Investigator | France | Besancon cedex | Besancon cedex |
| Centre Jean Bernard - Clinique Victor Hugo-Le Mans-France-C | Novartis' Investigator | France | Le Mans | Le Mans |
| Clinique Pasteur-Toulouse-France-C | Novartis' Investigator | France | Toulouse | Toulouse |
| Clinique Sainte Anne-Strasbourg cedex-France-C | Novartis' Investigator | France | Strasbourg cedex | Strasbourg cedex |
| Gem. Praxis Drs. Woerner und Rudolph-Kirchheim-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Kirchheim |
| Universitaetsklinikum Marburg-Urologie-Marburg-Germany-C | Novartis' Investigator | Germany | Hessen | Marburg |
| Praxis Dr. med. Jochen Wilke-Fuerth-Germany-C | Novartis' Investigator | Germany | Bayern | Fuerth |
| Helios Klinikum Erfurt-Urologie-Erfurt-Germany-C | Novartis' Investigator | Germany | Freistaat Thüringen | Erfurt |
| Universitaetsklinikum Bonn-Urologie-Bonn-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Bonn |
| Klinikum Offenbach GmbH-Urologische Klinik-Offenbach-Germany-C | Novartis' Investigator | Germany | Hessen | Offenbach |
| Universitaetsklinikum Muenster-Urologie-Muenster-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Muenster |
| Uniklinik Schleswig-Holstein-Campus Luebeck-Urolog-Luebeck-Germany-C | Novartis' Investigator | Germany | Schleswig-Holstein | Luebeck |
| Universitaetsklinikum des Saarlandes-Urologie-Homburg/Saar-Germany-C | Novartis' Investigator | Germany | Saarland | Homburg |
| Universitaetsklinikum Ulm-Urologie-Ulm-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Ulm |
| Praxis Dr. med. Ralf Eckert-Eisleben-Germany-C | Novartis' Investigator | Germany | Sachsen-Anhalt | Eisleben |
| Charite-Campus Mitte-Urologie-Berlin-Germany-C | Novartis' Investigator | Germany | Berlin | Berlin |
| Universitaetsklinikum Aachen-Urologie-Aachen-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Aachen |
| Praxis Dr. med. Goetz Geiges-Berlin-Germany-C | Novartis' Investigator | Germany | Berlin | Berlin |
| Katharinenhospital Stuttgart-Stuttgart-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Stuttgart |
| Universitaetsklinikum Jena-Urologie-Jena-Germany-C | Novartis' Investigator | Germany | Thueringen | Jena |
| Krankenhaus Am Urban-Berlin-Germany-C | Novartis' Investigator | Germany | Berlin | Berlin |
| Waldkrankenhaus St. Marien-Erlangen-Germany-C | Novartis' Investigator | Germany | Bayern | Erlangen |
| Praxis Dr. med. Toralf Kellner-Plauen-Germany-C | Novartis' Investigator | Germany | Sachsen | Plauen |
| Klinikum rechts der Isar-Urologie-Muenchen-Germany-C | Novartis' Investigator | Germany | Bayern | Muenchen |
| Klinikum der J. W. Goethe-Universitaet-Med. K. II-Frankfurt-Germany-C | Novartis' Investigator | Germany | Hessen | Frankfurt |
| Kreiskrankenhaus Sigmaringen-Urologie-Sigmaringen-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Sigmaringen |
| Praxis Dr. med. Hans Werner Tessen-Goslar-Germany-C | Novartis' Investigator | Germany | Niedersachsen | Goslar |
| Universitaetsklinikum der GHS Essen-Tumorforschung-Essen-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Essen |
| Martin-Luther-Universitaet Halle-Urologie-Halle-Germany-C | Novartis' Investigator | Germany | Sachsen-Anhalt | Halle |
| Johannes-Gutenberg-Universitaet Mainz-Urologie-Mainz-Germany-C | Novartis' Investigator | Germany | Rheinland-Pfalz | Mainz |
| Studienzentrum Onkologie Ravensburg im Brustzentru-Ravensburg-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Ravensburg |
| Staedtische Kliniken Neuss Lukaskrankenhaus-Urol.-Neuss-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Neuss |
| Caritas-Krankenhaus St. Josef-Urologie-Regensburg-Germany-C | Novartis' Investigator | Germany | Bayern | Regensburg |
| Duisburger Fachaerztegemeinschaft Urologie-Duisburg-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Duisburg |
| Klinikum Nordoberpfalz-Weiden-Urologie-Weiden-Germany-C | Novartis' Investigator | Germany | Bayern | Weiden |
| Zeisigwaldkliniken Bethanien-Urologie-Chemnitz-Germany-C | Novartis' Investigator | Germany | Sachsen | Chemnitz |
| Universitaetsklinikum Eppendorf-Urologie-Hamburg-Germany-C | Novartis' Investigator | Germany | Hamburg | Hamburg |
| Medizinische Hochschule Hannover-Urologie-Hannover-Germany-C | Novartis' Investigator | Germany | Niedersachsen | Hannover |
| Diakonissenkrankenhaus Dessau gGmbH-Urologie-Dessau-Germany-C | Novartis' Investigator | Germany | Sachsen-Anhalt | Dessau |
| Klinikum Bremen-Mitte gGmbH-Urologische Klinik-Bremen-Germany-C | Novartis' Investigator | Germany | Bremen | Bremen |
| Universitaetsklinikum Tuebingen-Urologie-Tuebingen-Germany-C | Novartis' Investigator | Germany | Baden-Wuerttemberg | Tuebingen |
| Klinikum Braunschweig-Urologische Klinik-Braunschweig-Germany-C | Novartis' Investigator | Germany | Niedersachsen | Braunschweig |
| Kliniken Maria Hilf-Klinik fuer Urologie-Moenchengladbach-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Moenchengladbach |
| Marien-Krankenhaus-Bergisch Gladbach-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Bergisch Gladbach |
| Gem. Praxis Drs. Nusch und Kalhori-Velbert-Germany-C | Novartis' Investigator | Germany | Nordrhein-Westfalen | Velbert |
| Klinikum Grosshadern-Urologie-Muenchen-Germany-C | Novartis' Investigator | Germany | Bayern | Muenchen |
| VITURO, Ges.f. klinische Studien, Ur-Leipzig-Germany-C | Novartis' Investigator | Germany | Sachsen | Leipzig |
| University Hospital of Patras-Patra-Greece-C | Novartis' Investigator | Greece | Rio-Patras | Rio-Patras |
| University Hospital of Heraklion-Heraklion, Crete-Greece-C | Novartis' Investigator | Greece | Heraklion, Crete | Heraklion, Crete |
| General Hospital of Athens | Novartis' Investigator | Greece | Athens | Athens |
| Agios Savvas Hospital-Athens-Greece-C | Novartis' Investigator | Greece | Athens | Athens |
| Euromedica General Clinic of Thessaloniki-Thessaloniki-Greece-C | Novartis' Investigator | Greece | Thessaloniki | Thessaloniki |
| Vas Megyei Markusovszky Lajos Kórház-Szombathely-Hungary-C | Novartis' Investigator | Hungary | Szombathely | Szombathely |
| Országos Onkológiai Intézet-Budapest-Hungary-C | Novartis' Investigator | Hungary | Budapest | Budapest |
| B-A-Z Megyei Kórház-Miskolc-Hungary-C | Novartis' Investigator | Hungary | Miskolc | Miskolc |
| Szabolcs-Szatmár-Bereg Megyei Onkormányzat-Nyíregyháza-Hungary-C | Novartis' Investigator | Hungary | Nyíregyháza | Nyíregyháza |
| Semmelweis Egyetem-Budapest-Hungary-C | Novartis' Investigator | Hungary | Budapest | Budapest |
| Fov Onk. Egyesített St István-St László Kórház-RI-Budapest-Hungary-C | Novartis' Investigator | Hungary | Budapest | Budapest |
| Beaumont Hospital-Dublin 9-Ireland-C | Novartis' Investigator | Ireland | Dublin | Dublin |
| Mater Misericordiae Hospital-Dublin-Ireland-C | Novartis' Investigator | Ireland | Dublin | Dublin |
| University Hospital Galway-Galway-Ireland-C | Novartis' Investigator | Ireland | Galway | Galway |
| Cork University Hospital-Cork-Ireland-C | Novartis' Investigator | Ireland | Wilton | Cork |
| Adelaide & Meath Hospital-Dublin-Ireland-C | Novartis' Investigator | Ireland | Dublin | Dublin |
| St Vincent's University Hospital - D-Dublin-Ireland-C | Novartis' Investigator | Ireland | Dublin | Dublin |
| Mater Private Hospital-Dublin-Ireland-C | Novartis' Investigator | Ireland | Dublin | Dublin |
| Rabin MC, Campus Beilinson-Petach Tikva-Israel-C | Novartis' Investigator | Israel | Petah-Tikva | Petah-Tikva |
| Kaplan MC-Rehovot-Israel-C | Novartis' Investigator | Israel | Rehovot | Rehovot |
| Rambam MC-Haifa-Israel-C | Novartis' Investigator | Israel | Haifa | Haifa |
| Hadassah Ein-Kerem MC.-Jerusalem-Israel-C | Novartis' Investigator | Israel | Jerusalem | Jerusalem |
| Assaf Harofeh MC-Zrifin-Israel-C | Novartis' Investigator | Israel | Zrifin | Zrifin |
| Tel-Aviv Sourasky MC-Tel Aviv-Israel-C | Novartis' Investigator | Israel | Tel Aviv | Tel Aviv |
| Policlinico di Modena - A.O. Universitaria-Modena-Italy-C | Novartis' Investigator | Italy | Emilia-Romagna | Modena |
| Fondazione IRCCS Policlinico San Matteo-Pavia-Italy-C | Novartis' Investigator | Italy | Lombardia | Pavia |
| Ospedale San Donato - USL 8-Arezzo-Italy-C | Novartis' Investigator | Italy | Toscana | Arezzo |
| Istituto Nazionale Tumori-Milano-Italy-C | Novartis' Investigator | Italy | Lombardia | Milano |
| Azienda Ospedaliera Santa Maria-Terni-Italy-C | Novartis' Investigator | Italy | Umbria | Terni |
| Ist per la Ricerca ed il Trattamento del Cancro-Candiolo (TO)-Italy-C | Novartis' Investigator | Italy | Piemonte | Candiolo |
| AO Rilievo Nazionale A.Cardarelli-Napoli-Italy-C | Novartis' Investigator | Italy | Campania | Napoli |
| AOU di Bologna Policlinico S.Orsola - Malpighi-Bologna-Italy-C | Novartis' Investigator | Italy | Emilia-Romagna | Bologna |
| Azienda Ospedaliera San Camillo Forlanini-Roma-Italy-C | Novartis' Investigator | Italy | Lazio | Roma |
| Ist. Scientifico Romagnolo Studio e Cura Tumori-Meldola (FC)-Italy-C | Novartis' Investigator | Italy | Emilia-Romagna | Meldola (FC) |
| Azienda Ospedaliera Sacro Cuore - Don Calabria-Negrar (Verona)-Italy-C | Novartis' Investigator | Italy | Veneto | Negrar |
| I.F.O. Regina Elena - San Gallicano-Roma-Italy-C | Novartis' Investigator | Italy | Lazio | Roma |
| Yamagata University Hospital-Yamagata-Japan-C | Novartis' Investigator | Japan | Yamagata | Yamagata |
| Keio University Hospital-Tokyo-Japan-C | Novartis' Investigator | Japan | Tokyo | Tokyo |
| Yokohama City University Hospital-Kanagawa-Japan-C | Novartis' Investigator | Japan | Kanagawa | Kanagawa |
| Okayama University Hospital-Okayama-Japan-C | Novartis' Investigator | Japan | Okayama | Okayama |
| The Cancer Institute Hospital of JFCR (Ariake)-Tokyo-Japan-C | Novartis' Investigator | Japan | Tokyo | Tokyo |
| Hokkaido University Hospital-Hokkaido-Japan-C | Novartis' Investigator | Japan | Hokkaido | Hokkaido |
| Nippon Medical School Hospital-Tokyo-Japan-C | Novartis' Investigator | Japan | Tokyo | Tokyo |
| Kyushu University Hospital-Fukuoka-Japan-C | Novartis' Investigator | Japan | Fukuoka | Fukuoka |
| Kinki University Hospital-Osaka-Japan-C | Novartis' Investigator | Japan | Osaka | Osaka |
| Hamamatsu University School of Medicine-Shizuoka-Japan-C | Novartis' Investigator | Japan | Shizuoka | Shizuoka |
| Tokyo Women's Medical University Hospital-Tokyo-Japan-C | Novartis' Investigator | Japan | Tokyo | Tokyo |
| Sapporo Medical University Hospital-Hokkaido-Japan-C | Novartis' Investigator | Japan | Hokkaido | Hokkaido |
| National Cancer Center-Gyeonggi-do-Korea-C | Novartis' Investigator | Korea, Republic of | Gyeonggi-do | Gyeonggi-do |
| Seoul National University Bundang Hospital-Seongnam-si, Gyeonggi-do-Korea-C | Novartis' Investigator | Korea, Republic of | Seongnam-si Gyeonggi-do | Seongnam-si Gyeonggi-do |
| Korea University Anam Hospital-Seoul-Korea-C | Novartis' Investigator | Korea, Republic of | Seoul | Seoul |
| Samsung Medical Center-Seoul-Korea-C | Novartis' Investigator | Korea, Republic of | Seoul | Seoul |
| Severance Hospital, YUCM-Seoul-Korea-C | Novartis' Investigator | Korea, Republic of | Seodaemun-gu, Seoul | Seodaemun-gu, Seoul |
| Seoul National University Hospital 1-Seoul-Korea-C | Novartis' Investigator | Korea, Republic of | Seoul | Seoul |
| Chonbuk National University Hospital-Chonju/Jeonju-Korea-C | Novartis' Investigator | Korea, Republic of | Jeonju | Jeonju |
| Chungnam National University Hospital-Daejeon-Korea-C | Novartis' Investigator | Korea, Republic of | Daejeon | Daejeon |
| Asan Medical Center-Seoul-Korea-C | Novartis' Investigator | Korea, Republic of | Seoul | Seoul |
| Centre Hospitalier de Luxembourg-Luxembourg-Luxembourg-C | Novartis' Investigator | Luxembourg | Luxembourg | Luxembourg |
| Wojewodzki Szpital Specjalistyczny-Wroclaw-Poland-C | Novartis' Investigator | Poland | Wroclaw | Wroclaw |
| NZOZ VESALIUS-Krakow-Poland-C | Novartis' Investigator | Poland | Kraków | Kraków |
| Centrum Onkologii Instytut im.M.Sklodowskiej-Curie-Krakow-Poland-C | Novartis' Investigator | Poland | Krakow | Krakow |
| Przychodnia Lekarska NZOZ Komed-Konin-Poland-C | Novartis' Investigator | Poland | Konin | Konin |
| Centrum Medyczne Ostrobramska NZOZ MAGODENT-Warszawa-Poland-C | Novartis' Investigator | Poland | Warszawa | Warszawa |
| Centrum Onkologii Ziemi Lubelskiej-Lublin-Poland-C | Novartis' Investigator | Poland | Lublin | Lublin |
| Szpital Kliniczny Przemienienia Panskiego-Poznan-Poland-C | Novartis' Investigator | Poland | Poznan | Poznan |
| NZOZ Mazowiecki Szpital Onkologiczny-Wieliszew-Poland-C | Novartis' Investigator | Poland | Wieliszew | Wieliszew |
| Centrum Onkologii-Instytut im.M.Sklodowskiej-Curie-Warszawa-Poland-C | Novartis' Investigator | Poland | Warszawa | Warszawa |
| Wojewodzkie Centrum Onkologii-Gdansk-Poland-C | Novartis' Investigator | Poland | Gdansk | Gdansk |
| ONKOLMED Lecznica Onkologiczna-Warszawa-Poland-C | Novartis' Investigator | Poland | Warszawa | Warszawa |
| Akademicki Szpital Kliniczny im. Jana Mikulicza-Wroclaw-Poland-C | Novartis' Investigator | Poland | Wroclaw | Wroclaw |
| Wojewodzki Szpital Specjalistyczny im.M. Kopernika-Lodz-Poland-C | Novartis' Investigator | Poland | Lodz | Lodz |
| Russian Scientific Center of Roentgeno-Radiology-Moscow-Russian Federation-C | Novartis' Investigator | Russian Federation | Moscow | Moscow |
| Russian Cancer Research Centre n.a Blokhin,RAMS-Moscow-Russian Federation-C | Novartis' Investigator | Russian Federation | Moscow | Moscow |
| City Hospital #2-Saint Petersburg-Russian Federation-C | Novartis' Investigator | Russian Federation | Saint Petersburg | Saint Petersburg |
| Petrov Research Institute of Oncology-St. Petersburg-Russian Federation-C | Novartis' Investigator | Russian Federation | St. Petersburg | St. Petersburg |
| Regional Clinical Oncology Dispensary-Ryazan-Russian Federation-C | Novartis' Investigator | Russian Federation | Ryazan | Ryazan |
| Tatarstan Republic Clinical Oncology Dispensary-Kazan-Russian Federation-C | Novartis' Investigator | Russian Federation | Kazan | Kazan |
| Sverdlovsk Regional Clinical Hospital-Ekaterinburg-Russian Federation-C | Novartis' Investigator | Russian Federation | Ekaterinburg | Ekaterinburg |
| Rostov Central Clinical Hospital-Rostov on Don-Russian Federation-C | Novartis' Investigator | Russian Federation | Rostov-na-Donu | Rostov-na-Donu |
| GUZ | Novartis' Investigator | Russian Federation | Ufa | Ufa |
| Stavropol Regional Clinical Oncological Dispensary-Stavropol-Russian Federation-C | Novartis' Investigator | Russian Federation | Stavropol | Stavropol |
| Regional Oncology Dispensary-Chelyabinsk-Russian Federation-C | Novartis' Investigator | Russian Federation | Chelyabinsk | Chelyabinsk |
| Oncology Dispensary-Omsk-Russian Federation-C | Novartis' Investigator | Russian Federation | Omsk | Omsk |
| Arkhangelsk Regional Oncology Dispensery-Arkhangelsk-Russian Federation-C | Novartis' Investigator | Russian Federation | Arkhangelsk | Arkhangelsk |
| Medical Roentgenology Resesarch Center-Obninsk-Russian Federation-C | Novartis' Investigator | Russian Federation | Obninsk | Obninsk |
| Altai Regional Oncology Dispensary-Barnaul-Russian Federation-C | Novartis' Investigator | Russian Federation | Barnaul | Barnaul |
| Univerzitna nemocnica L.Pasteura Kosice-Kosice-Slovakia-C | Novartis' Investigator | Slovakia | Kosice | Kosice |
| FNsP F.D. Roosevelta-Banska Bystrica-Slovakia-C | Novartis' Investigator | Slovakia | Banska Bystrica | Banska Bystrica |
| Fakultna nemocnica s poliklinikou Zilina-Zilina-Slovakia-C | Novartis' Investigator | Slovakia | Zilina | Zilina |
| Univerzitna nemocnica Martin-Martin-Slovakia-C | Novartis' Investigator | Slovakia | Martin | Martin |
| Univerzitna nemocnica Bratislava-Bratislava-Slovakia-C | Novartis' Investigator | Slovakia | Bratislava | Bratislava |
| Instituto Valenciano Oncologico-Valencia-Spain-C | Novartis' Investigator | Spain | Valencia | Valencia |
| Hospital 12 De Octubre-Madrid-Spain-C | Novartis' Investigator | Spain | Madrid | Madrid |
| Hospital Reina Sofia 1-Cordoba-Spain-C | Novartis' Investigator | Spain | Córdova | Córdoba |
| Hospital Virgen del Rocío-Sevilla-Spain-C | Novartis' Investigator | Spain | Sevilla | Sevilla |
| Hospital Central de Asturias-Oviedo-Spain-C | Novartis' Investigator | Spain | Oviedo | Oviedo |
| Hospital Clinico Universitario Virgen Victoria 2-Malaga-Spain-C | Novartis' Investigator | Spain | Málaga | Málaga |
| Hospital Universitario Valle de Hebr-Barcelona-Spain-C | Novartis' Investigator | Spain | Barcelona | Barcelona |
| Hospital Gregorio Maranon-Madrid-Spain-C | Novartis' Investigator | Spain | Madrid | Madrid |
| Hospital Germans Trias I Pujol 2-Badalona-Spain-C | Novartis' Investigator | Spain | Badalona | Badalona |
| Centro Oncológico Integral Clara Campal-Madrid-Spain-C | Novartis' Investigator | Spain | Madrid | Madrid |
| Hospital Clinic-Barcelona-Spain-C | Novartis' Investigator | Spain | Barcelona | Barcelona |
| Complejo Hospitalario Nuestra Sra. de Valme-Sevilla-Spain-C | Novartis' Investigator | Spain | Sevilla | Sevilla |
| MD Anderson-Madrid-Spain-C | Novartis' Investigator | Spain | Madrid | Madrid |
| Ege University SoM-Bornova/Izmir-Turkey-C | Novartis' Investigator | Turkey | Izmir | Izmir |
| Cukurova University School of Medicine-Adana-Turkey-C | Novartis' Investigator | Turkey | Adana | Adana |
| Ankara University Medical Faculty Ce-Ankara-Turkey-C | Novartis' Investigator | Turkey | Ankara | Ankara |
| Hacettepe University School of Medicine-Ankara-Turkey-C | Novartis' Investigator | Turkey | Ankara | Ankara |
| Istanbul University Oncology Institute-Istanbul-Turkey-C | Novartis' Investigator | Turkey | Istanbul | Istanbul |
| Royal Free Hospital-London-United Kingdom-C | Novartis' Investigator | United Kingdom | London | London |
| Royal Sussex County Hospital-Brighton-United Kingdom-C | Novartis' Investigator | United Kingdom | Brighton | Brighton |
| Bristol Haematology and Oncology Centre-Bristol-United Kingdom-C | Novartis' Investigator | United Kingdom | Gloucestershire | Bristol |
| Christie Hospital NHS Foundation Trust-Manchester-United Kingdom-C | Novartis' Investigator | United Kingdom | Manchester | Manchester |
| Royal Cornwall Hospital-Truro-United Kingdom-C | Novartis' Investigator | United Kingdom | Cornwall | Cornwall |
| Royal Preston Hospital-Preston-United Kingdom-C | Novartis' Investigator | United Kingdom | Lancashire | Preston |
| The Royal Wolverhampton Hospitals NHS Trust-Wolverhampton-United Kingdom-C | Novartis' Investigator | United Kingdom | Wolverhampton | Wolverhampton |
| Royal Surrey County Hospital NHS Foundation Trust-Guidlford, Surrey-United Kingdom-C | Novartis' Investigator | United Kingdom | Surrey | Guildford |
| Guy's & St THomas' NHS Foundation Trust-London-United Kingdom-C | Novartis' Investigator | United Kingdom | London | London |
| Singleton hospital-Swansea-United Kingdom-C | Novartis' Investigator | United Kingdom | West Glamorgan | Swansea |
| Tennessee Oncology PLLC-Chattanooga-United States-C | Novartis' Investigator | United States | Tennessee | Chattanooga |
| Duke University Medical Center-Durham-United States-C | Novartis' Investigator | United States | North Carolina | Durham |
| Mayo Clinic Cancer Center-Rochester-United States-C | Novartis' Investigator | United States | Minnesota | Rochester |
| Tyler Cancer Center-Tyler-United States-C | Novartis' Investigator | United States | Texas | Tyler |
| Northeast Georgia Cancer Care, LLC-Athens-United States-C | Novartis' Investigator | United States | Georgia | Athens |
| Ohio Sate University-Columbus-United States-C | Novartis' Investigator | United States | Ohio | Columbus |
| Kaiser Permanente Medical Center-San Jose-United States-C | Novartis' Investigator | United States | California | San Jose |
| Kaiser Permanente Medical Center-San Francisco-United States-C | Novartis' Investigator | United States | California | San Francisco |
| H. Lee Moffitt Cancer Center & Research Institute-Tampa-United States-C | Novartis' Investigator | United States | Florida | Tampa |
| University of Chicago Medical Center-Chicago-United States-C | Novartis' Investigator | United States | Illinois | Chicago |
| University Maryland Hospital-Baltimore-United States-C | Novartis' Investigator | United States | Maryland | Baltimore |
| University of California and Medical Center-San Diego-United States-C | Novartis' Investigator | United States | California | La Jolla |
| The University of Minnesota-Minneapolis-United States-C | Novartis' Investigator | United States | Minnesota | Minneapolis |
| Loyola University Medical Center 1-Maywood-United States-C | Novartis' Investigator | United States | Illinois | Maywood |
| Medical University of South Carolina-Charleston-United States-C | Novartis' Investigator | United States | South Carolina | Charleston |
| Fox Chase Cancer Center-Philadelphia-United States-C | Novartis' Investigator | United States | Pennsylvania | Philadelphia |
| Fox Chase Cancer Center-Philadelphia-United States-C | Novartis' Investigator | United States | Pennsylvania | Philadelphia |
| LAC & USC Medical Center 3-Los Angeles-United States-C | Novartis' Investigator | United States | California | Los Angeles |
| Rosewell Park Cancer Institute-Buffalo-United States-C | Novartis' Investigator | United States | New York | Buffalo |
| Sammons Cancer Center-Dallas-United States-C | Novartis' Investigator | United States | Texas | Dallas |
| Willamette Valley Cancer Center-Eugene-United States-C | Novartis' Investigator | United States | Oregon | Springfield |
| Huntsman Cancer Institute- University of Utah-Salt Lake City-United States-C | Novartis' Investigator | United States | Utah | Salt Lake City |
| MD Anderson Cancer Center-Orlando-United States-C | Novartis' Investigator | United States | Florida | Orlando |
| The Emory Clinic-Atlanta-United States-C | Novartis' Investigator | United States | Georgia | Atlanta |
| Eastern CT Hematology Oncology Associates-Norwich-United States-C | Novartis' Investigator | United States | Vermont | Norwich |
| Cancer Care Centers of South Texas-San Antonio-United States-C | Novartis' Investigator | United States | Texas | San Antonio |
| San Francisco Oncology Associates 1-San Francisco-United States-C | Novartis' Investigator | United States | California | San Francisco |
| Southeast Nebraska Cancer Center-Lincoln-United States-C | Novartis' Investigator | United States | Nebraska | Lincoln |
| Kaiser Permanente, Oakland-Oakland-United States-C | Novartis' Investigator | United States | California | Oakland |
| Illinois Cancer Care-Peoria-United States-C | Novartis' Investigator | United States | Illinois | Peoria |
| Karmanos Cancer Institute-Detroit-United States-C | Novartis' Investigator | United States | Michigan | Detroit |
| Northwestern University-Chicago-United States-C | Novartis' Investigator | United States | Illinois | Chicago |
| Rhode Island Hospital-Providence-United States-C | Novartis' Investigator | United States | Rhode Island | Providence |
| The Miriam Hospital-Providence-United States-C | Novartis' Investigator | United States | Rhode Island | Providence |
| University of Pennsylvania-Philadelphia-United States-C | Novartis' Investigator | United States | Pennsylvania | Philadelphia |
| Mayo Clinic of Scottsdale-Scottsdale-United States-C | Novartis' Investigator | United States | Arizona | Scottsdale |
| Greater Baltimore Medical Center-Baltimore-United States-C | Novartis' Investigator | United States | Maryland | Baltimore |
| Dartmouth-Hitchcock Medical Center-Lebanon-United States-C | Novartis' Investigator | United States | New Hampshire | Lebanon |
| Northwestern Carolina Oncology and Hematology-Hickory-United States-C | Novartis' Investigator | United States | North Carolina | Hickory |
| Cornell (New York Presbyterian Hospital)-New York-United States-C | Novartis' Investigator | United States | New York | New York |
| Rush University Medical Center-Chicago-United States-C | Novartis' Investigator | United States | Illinois | Chicago |
| The University of Texas Health Science Center-San Antonio-United States-C | Novartis' Investigator | United States | Texas | San Antonio |
| North Mississippi Hematology & Oncology Assoc-Tupelo-United States-C | Novartis' Investigator | United States | Mississippi | Tupelo |
| Case Western Reserve University-Cleveland-United States-C | Novartis' Investigator | United States | Ohio | Cleveland |
| Duke University Medical Center-Durham-United States-C | Novartis' Investigator | United States | North Carolina | Durhman |
| Seattle Cancer Care Alliance-Seattle-United States-C | Novartis' Investigator | United States | Washington | Seattle |
| University of Virginia Health Systems-Charlottesville-United States-C | Novartis' Investigator | United States | Virginia | Charlottesville |
| University of Cincinnati 3-Cincinnati-United States-C | Novartis' Investigator | United States | Ohio | Cincinnati |
| Virginia Mason Medical Center 1-Seattle-United States-C | Novartis' Investigator | United States | Washington | Seattle |
| University of California Irvine Medical Centre 3-Orange-United States-C | Novartis' Investigator | United States | California | Orange |
| Meharry Medical College-Nashville-United States-C | Novartis' Investigator | United States | Tennessee | Nashville |
| Texas Oncology, PA-Bedford-Bedford-United States-C | Novartis' Investigator | United States | Texas | Bedford |
| UCSF Comprehensive Cancer Center-San Francisco-United States-C | Novartis' Investigator | United States | California | San Francisco |
| Washington University, Barnes-Jewish Hospital-St. Louis-United States-C | Novartis' Investigator | United States | Missouri | St. Louis |
| Utah Cancer Specialists-Salt Lake City-United States-C | Novartis' Investigator | United States | Utah | Salt Lake City |
| University of Iowa-Iowa City-United States-C | Novartis' Investigator | United States | Iowa | Iowa City |
| Beth Israel Deaconess Medical Cnt/Harvard Medical-Boston-United States-C | Novartis' Investigator | United States | Massachusetts | Boston |
| Hudson Valley Urology-Poughkeepsie-United States-C | Novartis' Investigator | United States | New York | Poughkeepsie |
| Hackensack University Medical Center-Hackensack-United States-C | Novartis' Investigator | United States | New Jersey | Hackensack |
| University Of Texas MD Anderson Cancer Center 3-Houston-United States-C | Novartis' Investigator | United States | Texas | Houston |
| Cedar Sinai Medical Center-West Hollywood-United States-C | Novartis' Investigator | United States | California | Los Angeles |
| The West Clinic-Memphis-United States-C | Novartis' Investigator | United States | Tennessee | Memphis |
| Kaiser Permanente Medical Center-Santa Clara-United States-C | Novartis' Investigator | United States | California | Santa Clara |
| Highline Medical Oncology-Burien-United States-C | Novartis' Investigator | United States | Washington | Burien |
| Tower Hematology Oncology Medical Group-Beverly Hills-United States-C | Novartis' Investigator | United States | California | Beverly Hills |
| Doctors Medical Center -JC Robinson Reg Cancer Ctr-San Pablo-United States-C | Novartis' Investigator | United States | California | San Pablo |
| Peachtree-Hematology Oncology Consultants-Atlanta-United States-C | Novartis' Investigator | United States | Georgia | Atlanta |
| Urology of Virginia-Virginia Beach-United States-C | Novartis' Investigator | United States | Virginia | Norfolk |
| Stanford University Clinical Cancer Center-Stanford-United States-C | Novartis' Investigator | United States | California | Stanford |
| UMass Memorial Medical Center-Worcester-United States-C | Novartis' Investigator | United States | Massachusetts | Worcester |
| Norris Comprehensive Cancer Center-Los Angeles-United States-C | Novartis' Investigator | United States | California | Los Angeles |
| Temple University-Philadelphia-United States-C | Novartis' Investigator | United States | Pennsylvania | Philadelphia |
| Indiana University Cancer Center-6-Indianapolis-United States-C | Novartis' Investigator | United States | Indiana | Indianapolis |
| Virginia Oncology Associates-Hampton-United States-C | Novartis' Investigator | United States | Virginia | Hampton |
| Lakeland Regional Cancer Center-Lakeland-United States-C | Novartis' Investigator | United States | Florida | Lakeland |
| Columbia Presbyterian Medical Center-New York-United States-C | Novartis' Investigator | United States | New York | New York |
| Kaiser Permanente Medical Center-Vallejo-United States-C | Novartis' Investigator | United States | California | Vallejo |
| Joe Arrington Cancer Center-Lubbock-United States-C | Novartis' Investigator | United States | Texas | Lubbock |
| Kaiser Permanente Walnut Creek-Walnut Creek-United States-C | Novartis' Investigator | United States | California | Walnut Creek |
| Massachusetts General Hospital Cancer Center-Boston-United States-C | Novartis' Investigator | United States | Massachusetts | Boston |
| The Vanderbilt Clinic-Nashville-United States-C | Novartis' Investigator | United States | Tennessee | Nashville |
| Georgetown University Medical Center-Washington-United States-C | Novartis' Investigator | United States | District of Columbia | Washington |
| Akron General Medical Center-Akron-United States-C | Novartis' Investigator | United States | Ohio | Akron |
| Brinz Burroff Gurtler Russo Mds-Metairie-United States-C | Novartis' Investigator | United States | Louisiana | Metairie |
| Jefferson Hospital-Philadelphia-United States-C | Novartis' Investigator | United States | Pennsylvania | Philadelphia |
| Pennsylvania Oncology Hematology Associates-Philadelphia-United States-C | Novartis' Investigator | United States | Tennessee | Memphis |
| Virginia Cancer Care-Richmond-United States-C | Novartis' Investigator | United States | Virginia | Richmond |
| Cleveland Clinic-Cleveland-United States-C | Novartis' Investigator | United States | Ohio | Cleveland |
| Hematology Oncology Medical Group of Fresno-Fresno-United States-C | Novartis' Investigator | United States | California | Fresno |
| Kaiser Permanente - Roseville-Roseville-United States-C | Novartis' Investigator | United States | California | Roseville |
| Medical Oncology Associates-Spokane-United States-C | Novartis' Investigator | United States | Washington | Spokane |
| St. Louis VA Medical Center-St. Louis-United States-C | Novartis' Investigator | United States | Missouri | St. Louis |
| Front Range Cancer Specialists-Fort Collins-United States-C | Novartis' Investigator | United States | Colorado | Fort Collins |
| New York Oncology Hematology-Albany-United States-C | Novartis' Investigator | United States | New York | Albany |
| Providence Medical Center-Portland-United States-C | Novartis' Investigator | United States | Oregon | Portland |
| Beth Israel Comprehensive Cancer Center-New York-United States-C | Novartis' Investigator | United States | New York | New York |
| Mercy Physicians of Oklahoma - Mercy Health Center-Oklahoma City-United States-C | Novartis' Investigator | United States | Oklahoma | Oklahoma City |
| Florida Cancer-Ft. Myers-United States-C | Novartis' Investigator | United States | Virginia | Ft. Myer |
| Feinberg School of Medicine Dept. of Urology-Chicago-United States-C | Novartis' Investigator | United States | Illinois | Chicago |
| Suniti Medical Corporation-Merrillville-United States-C | Novartis' Investigator | United States | Indiana | Merriville |
| Summit Cancer Ctr-2-Savannah-United States-C | Novartis' Investigator | United States | Georgia | Savannah |
| Texas Oncology-Houston-United States-C | Novartis' Investigator | United States | Texas | The Woodlands |
| Dana Farber Cancer Institute-Boston, MA-United States-C | Novartis' Investigator | United States | Massachusetts | Boston |
| Comprehensive Cancer Centers of Nevada-Eastern-Las Vegas-United States-C | Novartis' Investigator | United States | Nevada | Las Vegas |
| Florida Cancer Specialists-Fort Myers-United States-C | Novartis' Investigator | United States | Florida | Fort Myers |
| Tennessee Oncology-Nashville-United States-C | Novartis' Investigator | United States | Tennessee | Nashville |
| Oncology Hematology Care-Cincinnati-United States-C | Novartis' Investigator | United States | Ohio | Cincinnati |
| University of Cincinnati-Cincinnati-United States-C | Novartis' Investigator | United States | Ohio | Cincinnati |
| Duluth Clinic-Duluth-United States-C | Novartis' Investigator | United States | Minnesota | Duluth |
| Lahey Clinic-Burlington-United States-C | Novartis' Investigator | United States | Massachusetts | Burlington |
| Robert Wood Johnson Medical School-New Brunswick-United States-C | Novartis' Investigator | United States | New Jersey | New Brunswick |
| Nebraska Medical Center-Omaha-United States-C | Novartis' Investigator | United States | Nebraska | Omaha |
| David Geffen School of Medicine at UCLA-Los Angeles-United States-C | Novartis' Investigator | United States | California | Los Angeles |
| Kaiser Satellite South San Francisco-South San Francisco-United States-C | Novartis' Investigator | United States | California | South San Francisco |
| Clopton Clinic-Jonesboro-United States-C | Novartis' Investigator | United States | Tennessee | Memphis |
| Methodist Eastbrook Cancer Center-Omaha-United States-C | Novartis' Investigator | United States | Nebraska | Omaha |
| Park Nicollet Institute-St. Louis Park-United States-C | Novartis' Investigator | United States | Minnesota | St. Louis Park |
| University of Miami - Sylvester Cancer Center-Miami-United States-C | Novartis' Investigator | United States | Florida | Miami |
| Central Georgia Cancer Care, P.C.-Macon-United States-C | Novartis' Investigator | United States | Tennessee | Memphis |
| Clinical Trials Research Associated, Inc.-Montebello-United States-C | Novartis' Investigator | United States | California | Montebello |
| Kaiser Permanente Hayward-Hayward-United States-C | Novartis' Investigator | United States | California | Hayward |
| Kaiser Permanente Sacramento-Sacramento-United States-C | Novartis' Investigator | United States | California | Sacramento |
| St. Luke's - Roosevelt Hospital Center-New York-United States-C | Novartis' Investigator | United States | New York | New York |
| University of Michigan-Ann Arbor-United States-C | Novartis' Investigator | United States | Michigan | Ann Arbor |
| Johns Hopkins University-Baltimore-United States-C | Novartis' Investigator | United States | Maryland | Baltimore |
| 北京301 医院 | 张旭 | 中国 | 北京 | 北京 |
伦理委员会信息
| 名称 | 审查结论 | 审查日期 |
|---|---|---|
| 复旦大学附属肿瘤医院（该研究的国内组长机构）医学伦理委员会 | 修改后同意 | 2011-11-28 |
| 复旦大学附属肿瘤医院医学伦理委员会 | 同意 | 2017-08-28 |
试验状态信息
试验状态
已完成
目标入组人数
国内: 40 ；
国际: 1500 ；
已入组例数
国内: 37 ；
国际: 1538 ；
实际入组总例数
国内: 37 ；
国际: 1538 ；
第一例受试者签署知情同意书日期
国内：2011-12-30；
国际：2010-11-30；
第一例受试者入组日期
国内：2012-01-13；
国际：2010-12-09；
试验终止日期
国内：2019-01-30；
国际：2019-04-15；
临床试验结果摘要
| 版本号 | 版本日期 |
|---|
